|M. Jackson Stutts, PhD, Professor of Medicine|
We have long known that ENaC mediated Na+ absorption by airway epithelia of CF patients is elevated. Our lab and colleagues recently documented that the absence of functional CFTR causes abnormal stimulation of ENaC by cAMP and excessive proteolytic activation of ENaC. Presently, we are designing experiments to test the possibility that these deranged ENaC regulatory pathways are connected.
M. Jackson Stutts, PhD, Principal Investigator, Professor of Medicine
Yan Dang, Research Specialist and Laboratory Manager
Hong He, Research Specialist
Contact Information6023 Thurston-Bowles Bldg.
The University of North Carolina at Chapel Hill
Campus Box #7248
Chapel Hill, NC 27599
Phone: (919) 966-7057
Fax: (919) 966-5178