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Specialty Areas:

Mucin Synthesis Pathways and Secretion in Human Bronchial Epithelial Cells

Research Focus:

Lubna Abdullah is studying the pathways underlying mucin synthesis and secretion in human bronchial epithelial cells. Of specific interest is the post-secretory maturation of mucins, which may be dysfunctional in cystic fibrosis, the relationships between mucin glycoprotein secretion and synthesis under control versus inflammatory conditions, and the branches of the secretory pathway used for mucin secretion.

Selected Bibliography:

  1. Abdullah LH, Coakley R, Webster MJ, Zhu Y, Tarran R, Radicioni G, Kesimer M, Boucher RC, Davis CW, Ribeiro CMP. Mucin production and hydration responses to mucopurulent materials in normal vs. CF airway epithelia. Am J Respir Crit Care Med. 2018 Feb 15;197(4):481-491. doi: 10.1164/rccm.201706-1139OC. PMID: 29099608; PMCID: PMC5821906.
  2. Abdullah LH, Evans JR, Wang TT, Ford AA, Makhov AM, Nguyen K, Coakley RD, Griffith JD, Davis CW, Ballard ST, Kesimer M. Defective postsecretory maturation of MUC5B mucin in cystic fibrosis airways. JCI Insight. 2017 Mar 23;2(6):e89752. doi: 10.1172/jci.insight.89752. PMID: 28352653; PMCID: PMC5358479.
  3. Zhu Y, Abdullah LH, Doyle SP, Nguyen K, Ribeiro CM, Vasquez PA, Forest MG, Lethem MI, Dickey BF, Davis CW. Baseline goblet cell mucin secretion in the airways exceeds stimulated secretion over extended time periods, and is sensitive to shear stress and intracellular mucin stores. PLoS One. 2015 May 29;10(5):e0127267. doi: 10.1371/journal.pone.0127267. eCollection 2015. PubMed PMID: 26024524; PubMed Central PMCID: PMC4449158.
  4. Schwab U, Abdullah LH, Perlmutt OS, Albert D, Davis CW, Arnold RR, Yankaskas JR, Gilligan P, Neubauer H, Randell SH, Boucher RC. Localization of Burkholderia cepacia complex bacteria in cystic fibrosis lungs and interactions with Pseudomonas aeruginosa in hypoxic mucus. Infect Immun. 2014 Nov;82(11):4729-45. doi: 10.1128/IAI.01876-14. Epub 2014 Aug 25. PubMed PMID: 25156735; PubMed Central PMCID: PMC4249344.
  5. Henderson AG, Ehre C, Button B, Abdullah LH, Cai LH, Leigh MW, DeMaria GC, Matsui H, Donaldson SH, Davis CW, Sheehan JK, Boucher RC, Kesimer M. Cystic fibrosis airway secretions exhibit mucin hyperconcentration and increased osmotic pressure. J Clin Invest. 2014 Jul;124(7):3047-60. doi: 10.1172/JCI73469. Epub 2014 Jun 2. PubMed PMID: 24892808; PubMed Central PMCID: PMC4072023.
  6. Haddock BJ, Zhu Y, Doyle SP, Abdullah LH, Davis CW. Role of MARCKS in regulated secretion from mast cells and airway goblet cells. Am J Physiol Lung Cell Mol Physiol. 2014 May 15;306(10):L925-36. doi: 10.1152/ajplung.00213.2013. Epub 2014 Apr 4. PubMed PMID: 24705720.
Lubna Abdullah