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Saira Ahmad, PhD

Research Associate

Specialty Areas:

Airway infection and inflammation

Selected Bibliography:

  1. Wu T, Goriounova AS, Worthington EN, Wrennall JA, Ghosh A, Ahmad S, Flori Sassano M, Tarran R. SPLUNC1 is a negative regulator of the Orai1 Ca2+ channel. Physiol Rep. 2022 May;10(10):e15306. doi: 10.14814/phy2.15306. PMID: 35581745; PMCID: PMC9114653.
  2. Wrennall JA, Ahmad S, Worthington EN, Wu T, Goriounova AS, Voeller AS, Stewart IE, Ghosh A, Krajewski K, Tilley SL, Hickey AJ, Sassano MF, Tarran R. A SPLUNC1 Peptidomimetic Inhibits Orai1 and Reduces Inflammation in a Murine Allergic Asthma Model. Am J Respir Cell Mol Biol. 2022 Mar;66(3):271-282. doi: 10.1165/rcmb.2020-0452OC. PMID: 34807800. PMCID: PMC8937239.
  3. Ghosh A, Ahmad S, Coakley RD, Sassano MF, Alexis NE, Tarran R. Lipid-Laden Macrophages are not Unique to EVALI Patients. Am J Respir Crit Care Med. 2021 Apr 15;203(8):1030-1033. doi: 10.1164/rccm.202009-3507LE. PMID: 33332247. PMCID: PMC8048758.
  4. Ahmad S, Sassano MF, Tarran R. Loose ENDs: Electronic Nicotine Delivery Systems and the FDA’s Recent Enforcement Policy. Eur Med J Respir. 2020 Nov;8(1):93-96. PMID: 34336231; PMCID: PMC8323585.
  5. Ahmad S, Kim CSK, Tarran R. The SPLUNC1-βENaC complex prevents Burkholderia cenocepacia invasion in normal airway epithelia. Respir Res. 2020 Jul 17;21(1):190. doi: 10.1186/s12931-020-01454-5. PMID: 32680508; PMCID: PMC7368771.
  6. Ahmad S, Gilmore RC, Alexis NE, Tarran R. SPLUNC1 Loses Its Antimicrobial Activity in Acidic Cystic Fibrosis Airway Secretions. Am J Respir Crit Care Med. 2019 Sep 1;200(5):633-636. doi: 10.1164/rccm.201812-2303LE. PMID: 31013116; PMCID: PMC6727152.
  7. Kim CS, Ahmad S, Wu T, Walton WG, Redinbo MR, Tarran R. SPLUNC1 is an allosteric modulator of the epithelial sodium channel. FASEB J. 2018 May;32(5):2478-2491. doi: 10.1096/fj.201701126R. PMID: 29295861. PMCID: PMC5901381.
  8. Terryah ST, Fellner RC, Ahmad S, Moore PJ, Reidel B, Sesma JI, Kim CS, Garland AL, Scott DW, Sabater JR, Carpenter J, Randell SH, Kesimer M, Abraham WM, Arendshorst WJ, Tarran R. Evaluation of a SPLUNC1-derived peptide for the treatment of cystic fibrosis lung disease. Am J Physiol Lung Cell Mol Physiol. 2018 Jan 1;314(1):L192-L205. doi: 10.1152/ajplung.00546.2016. PMID: 28982737. PMCID: PMC5866433.
  9. Ahmad S, Tyrrell J, Walton WG, Tripathy A, Redinbo MR, Tarran R. Short palate, lung, and nasal epithelial clone 1 has antimicrobial and antibiofilm activities against the Burkholderia cepacia complex. Antimicrob Agents Chemother. 2016 Sep 23;60(10):6003-12. doi: 10.1128/AAC.00975-16. PMID: 27458217. PMCID: PMC5038247.
  10. Walton WG, Ahmad S, Little MS, Kim CS, Tyrrell J, Lin Q, Di YP, Tarran R, Redinbo MR. Structural features essential to the antimicrobial functions of human SPLUNC1. Biochemistry. 2016 May 31;55(21):2979-91. doi: 10.1021/acs.biochem.6b00271. PMID: 27145151. PMCID: PMC4887393.
Saira Ahmad, PhD