{"id":5771,"date":"2023-12-19T08:47:52","date_gmt":"2023-12-19T13:47:52","guid":{"rendered":"https:\/\/www.med.unc.edu\/marsicolunginstitute\/?post_type=directory&p=5771"},"modified":"2026-04-09T17:24:56","modified_gmt":"2026-04-09T21:24:56","slug":"yogesh-saini-dvm-mvsc-phd","status":"publish","type":"directory","link":"https:\/\/www.med.unc.edu\/marsicolunginstitute\/directory\/yogesh-saini-dvm-mvsc-phd\/","title":{"rendered":"Yogesh Saini, DVM, MVSc, PhD"},"content":{"rendered":"

Specialty Areas:<\/h2>\n

Lung Inflammation, Macrophage Biology, Inhalation Toxicology, Hepatotoxicity<\/p>\n

Education:<\/h2>\n

DVM<\/strong>, College of Veterinary and Animal Sciences – Palampur, India (2001)<\/p>\n

MVSc<\/strong>, Veterinary Biochemistry and Biotechnology, College of Veterinary Sciences, Pantnager, India (2003)<\/p>\n

Dual-PhD<\/strong>, Genetics and Integrative Toxicology, Michigan State University (2009)<\/p>\n

Selected Bibliography:<\/h2>\n
    \n
  1. Fresquez SE, Sivaraman V, Saini Y<\/strong>, Walker D, Chavis T, Soule E, Sousan S. Impacts of Mislabeled ECIG Liquids on Primary Particulate Matter Emissions<\/a>. Toxics. 2026 Mar 13;14(3):256. doi: 10.3390\/toxics14030256. PMID: 41893524; PMCID: PMC13029940.<\/li>\n
  2. Lamichhane R, Choudhary I, Singamsetty D, Patial S, Saini Y<\/strong>. Tristetraprolin protects against ozone-induced acute lung injury and inflammation in mice<\/a>. J Immunol. 2026 Jan 21;215(1):vkaf221. doi: 10.1093\/jimmun\/vkaf221. PMID: 41379025; PMCID: PMC12836256.<\/li>\n
  3. Mao Y, Patial S, Saini Y<\/strong>. Myeloid cell-specific HMGB1 deficiency exaggerates mucoinflammatory responses but promotes bacterial clearance in mucoinflammatory lung disease<\/a>. Sci Rep. 2026 Jan 12;16(1):3391. doi: 10.1038\/s41598-025-33357-0. PMID: 41526418; PMCID: PMC12834952.<\/li>\n
  4. Vo T, Choudhary I, Patial S, Saini Y<\/strong>. Single-cell transcriptomics reveal alveolar macrophages-specific responses in single-hit ozone exposure model in mice<\/a>. Am J Physiol Lung Cell Mol Physiol. 2026 Jan 2. doi: 10.1152\/ajplung.00235.2025. Epub ahead of print. PMID: 41481288.<\/li>\n
  5. Bayless R, Saini Y<\/strong>. Optimizing Neutrophil Recruitment to Tackle Bacterial Infections?<\/a> Am J Respir Cell Mol Biol. 2025 Jul;73(1):3-5. doi: 10.1165\/rcmb.2024-0575ED. PMID: 39836037. PMCID: PMC12254682.<\/li>\n
  6. Vo T, Patial S, Saini Y<\/strong>. Repetitive ozone exposure worsens features of muco-inflammatory disease in developed Scnn1b<\/em>-Tg+ mice lungs<\/a>. Front Toxicol. 2025 May 27;7:1540468. doi: 10.3389\/ftox.2025.1540468. PMID: 40496925; PMCID: PMC12148915.<\/li>\n
  7. Choudhary I, Paudel K, Kumar R, Sharma A, Patial S, Saini Y<\/strong>. Airway epithelial cell-specific deletion of EGFR modulates mucoinflammatory features of cystic fibrosis-like lung disease in mice<\/a>. Front Immunol. 2025 May 8;16:1493950. doi: 10.3389\/fimmu.2025.1493950. PMID: 40406132; PMCID: PMC12094982.<\/li>\n
  8. Choudhary I, Lamichhane R, Singamsetty D, Vo T, Brombacher F, Patial S, Saini Y<\/strong>. Cell-Specific Contribution of IL-4 Receptor \u03b1 Signaling Shapes the Overall Manifestation of Allergic Airway Disease<\/a>. Am J Respir Cell Mol Biol. 2024 Dec;71(6):702-717. doi: 10.1165\/rcmb.2024-0208OC. PMID: 39254378; PMCID: PMC11622633.<\/li>\n
  9. Mao Y, Suryawanshi A, Patial S, Saini Y<\/strong>. Airspaces-derived exosomes contain disease-relevant protein signatures in a mouse model of cystic fibrosis (CF)-like mucoinflammatory lung disease<\/a>. Front Pharmacol. 2024 Sep 25;15:1460692. doi: 10.3389\/fphar.2024.1460692. PMID: 39386033; PMCID: PMC11461968.<\/li>\n
  10. Paudel S, Kumar R, Rogers KA, Saini Y<\/strong>, Patial S, Kulkarni R. The NLRP3 Inflammasome Is Dispensable in Methicillin-Resistant Staphylococcus aureus Urinary Tract Infection<\/a>. Pathogens. 2024 Jan 25;13(2):106. doi: 10.3390\/pathogens13020106. PMID: 38392844; PMCID: PMC10893321.<\/li>\n
  11. Das DN, Puthusseri B, Gopu V, Krishnan V, Bhagavath AK, Bolla S, Saini Y<\/strong>, Criner GJ, Marchetti N, Tang H, Konduru NV, Fan L, Shetty S. Caveolin-1-derived peptide attenuates cigarette smoke-induced airway and alveolar epithelial injury<\/a>. Am J Physiol Lung Cell Mol Physiol. 2023 Nov 1;325(5):L689-L708. doi: 10.1152\/ajplung.00178.2022. PMID: 37642665. PMCID: PMC11178264.<\/li>\n
  12. Sundar IK, Duraisamy SK, Choudhary I, Saini Y<\/strong>, Silveyra P. Acute and Repeated Ozone Exposures Differentially Affect Circadian Clock Gene Expression in Mice<\/a>. Adv Biol (Weinh). 2023 Nov;7(11):e2300045. doi: 10.1002\/adbi.202300045. PMID: 37204107; PMCID: PMC10657336.<\/li>\n
  13. Mao Y, Patial S, Saini Y<\/strong>. Airway epithelial cell-specific deletion of HMGB1 exaggerates inflammatory responses in mice with muco-obstructive airway disease<\/a>. Front Immunol. 2023 Jan 19;13:944772. doi: 10.3389\/fimmu.2022.944772. PMID: 36741411; PMCID: PMC9892197.<\/li>\n
  14. Vo T, Saini Y<\/strong>. Case report: Mafb promoter activity may define the alveolar macrophage dichotomy<\/a>. Front Immunol. 2022 Dec 12;13:1050494. doi: 10.3389\/fimmu.2022.1050494. PMID: 36578483; PMCID: PMC9791191.<\/li>\n
  15. Kumar R, Mao Y, Patial S, Saini Y<\/strong>. Induction of whole-body gene deletion via R26-regulated tamoxifen-inducible Cre recombinase activity<\/a>. Front Pharmacol. 2022 Dec 8;13:1018798. doi: 10.3389\/fphar.2022.1018798. PMID: 36569322; PMCID: PMC9772612.<\/li>\n
  16. Lamichhane R, Patial S, Saini Y<\/strong>. Higher susceptibility of males to bleomycin-induced pulmonary inflammation is associated with sex-specific transcriptomic differences in myeloid cells<\/a>. Toxicol Appl Pharmacol. 2022 Nov 1;454:116228. doi: 10.1016\/j.taap.2022.116228. PMID: 36087614; PMCID: PMC9793441.<\/li>\n
  17. Lewis BW, Patial S, Saini Y<\/strong>. In Vitro Screening Method for Characterization of Macrophage Activation Responses<\/a>. Methods Protoc. 2022 Aug 30;5(5):68. doi: 10.3390\/mps5050068. PMID: 36136814; PMCID: PMC9498385.<\/li>\n
  18. Vo T, Paudel K, Choudhary I, Patial S, Saini Y<\/strong>. Ozone exposure upregulates the expression of host susceptibility protein TMPRSS2 to SARS-CoV-2<\/a>. Sci Rep. 2022 Jan 25;12(1):1357. doi: 10.1038\/s41598-022-04906-8. PMID: 35079032; PMCID: PMC8789794.<\/li>\n<\/ol>\n

    View all publications<\/strong><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

    Specialty Areas: Lung Inflammation, Macrophage Biology, Inhalation Toxicology, Hepatotoxicity Education: DVM, College of Veterinary and Animal Sciences – Palampur, India (2001) MVSc, Veterinary Biochemistry and Biotechnology, College of Veterinary Sciences, Pantnager, India (2003) Dual-PhD, Genetics and Integrative Toxicology, Michigan State University (2009) Selected Bibliography: Fresquez SE, Sivaraman V, Saini Y, Walker D, Chavis T, Soule … Read more<\/a><\/p>\n","protected":false},"featured_media":5772,"template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","_links_to":"","_links_to_target":""},"class_list":["post-5771","directory","type-directory","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"yoast_head":"\nYogesh Saini, DVM, MVSc, PhD | Marsico Lung Institute<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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