{"id":762,"date":"2015-10-21T12:56:00","date_gmt":"2015-10-21T16:56:00","guid":{"rendered":"https:\/\/med.sites.unc.edu\/cfpulmcenter\/directory\/michael-chua-phd-2\/"},"modified":"2026-03-24T13:53:13","modified_gmt":"2026-03-24T17:53:13","slug":"michael-chua-phd","status":"publish","type":"directory","link":"https:\/\/www.med.unc.edu\/marsicolunginstitute\/directory\/michael-chua-phd\/","title":{"rendered":"Michael Chua, PhD"},"content":{"rendered":"

<\/p>\n

Specialty Areas:<\/h2>\n

Development of Novel Light Microscopy and Imaging Technologies for Cell Biology and Physiology<\/p>\n

Selected Bibliography:<\/h2>\n
    \n
  1. Schworer SA, Murano H, Dang H, Markovetz MR, Saito M, Kato T, Asakura T, Chen G, Gilmore RC, Morton LC, van Heusden C, Chua M<\/strong>, Strickler E, Wisniewski ZY, Crisp G, Mitchell E, Doherty KA, Mastan S, Trejo Bittar HE, Cody BA, Trudeau JB, De la Cruz G, Ralph LM, Askin FB, Panettieri RA Jr, Koziol-White CJ, Byrd KM, Livraghi-Butrico A, O’Neal WK, Randell SH, Wenzel SE, Okuda K, Boucher RC Jr. Airway Epithelial Heterogeneity and Mucus Plugging in Asthmatic Bronchioles<\/a>. Am J Respir Crit Care Med. 2026 Feb;212(2):209-226. doi: 10.1164\/rccm.202409-1849OC. PMID: 40986379. PMCID: PMC12668797.<\/li>\n
  2. Sun L, Walls SA, Dang H, Quinney NL, Sears PR, Sadritabrizi T, Hasegawa K, Okuda K, Asakura T, Chang X, Zheng M, Mikami Y, Dizmond FU, Danilova D, Zhou L, Deshmukh A, Cholon DM, Radicioni G, Rogers TD, Kissner WJ, Markovetz MR, Guhr Lee TN, Gutay MI, Esther CR Jr, Chua M<\/strong>, Grubb BR, Ehre C, Kesimer M, Hill DB, Ostrowski LE, Button B, Gentzsch M, Robinson C, Olivier KN, Freeman AF, Randell SH, Vladar E, O’Neal WK, Boucher RC Jr, Chen G. STAT3-dependent Regulation of CFTR and Ciliogenesis Is Essential for Mucociliary Clearance and Innate Airway Defense in Hyper-IgE Syndrome<\/a>. Am J Respir Crit Care Med. 2025 Oct;211(10):1951-1969. doi: 10.1164\/rccm.202407-1415OC. PMID: 40315437. PMCID: PMC12555045.<\/li>\n
  3. Asakura T, Okuda K, Chen G, Dang H, Kato T, Mikami Y, Schworer SA, Gilmore RC, Radicioni G, Hawkins P, Barbosa Cardenas SM, Saito M, Cawley AM, De la Cruz G, Chua M<\/strong>, Alexis NE, Masugi Y, Noone PG, Ribeiro CMP, Kesimer M, Olivier KN, Hasegawa N, Randell SH, O’Neal WK, Boucher RC. Proximal and Distal Bronchioles Contribute to the Pathogenesis of Non-Cystic Fibrosis Bronchiectasis (NCFB)<\/a>. Am J Respir Crit Care Med. 2024 Feb 15;209(4):374-389. doi: 10.1164\/rccm.202306-1093OC. PMID: 38016030. PMCID: PMC10878387.<\/li>\n
  4. Okuda K, Dang H, Kobayashi Y, Carraro G, Nakano S, Chen G, Kato T, Asakura T, Gilmore RC, Morton LC, Lee RE, Mascenik T, Yin WN, Barbosa Cardenas SM, O\u2019Neal YK, Minnick CE, Chua M<\/strong>, Quinney NL, Gentzsch M, Anderson CW, Ghio A, Matsui H, Nagase T, Ostrowski LE, Grubb BR, Olsen JC, Randell SH, Stripp BR, Tata PR, O\u2019Neal WK, Boucher RC. Secretory Cells Dominate Airway CFTR Expression and Function in Human Airway Superficial Epithelia<\/a>. Am J Respir Crit Care Med. 2021 May 15;203(10):1275-1289. PMID: 33321047. PMCID: PMC8456462.<\/li>\n
  5. Okuda K, Chen G, Subramani DB, Wolf M, Gilmore RC, Kato T, Radicioni G, Kesimer M, Chua M<\/strong>, Dang H, Livraghi-Butrico A, Ehre C, Doerschuk CM, Randell SH, Matsui H, Nagase T, O’Neal WK, Boucher RC.\u00a0Localization of Secretory Mucins MUC5AC and MUC5B in Normal\/Healthy Human Airways<\/a>. Am J Respir Crit Care Med. 2019 Mar 15;199(6):715-727. PMID: 30352166; PMCID:\u00a0PMC6423099.<\/li>\n
  6. Gupta R, Radicioni G, Abdelwahab S, Dang H, Carpenter J, Chua M<\/strong>, Mieczkowski PA, Sheridan J, Randell SH, Kesimer M. Intercellular Communication between Airway Epithelial Cells is Mediated by Exosome-Like Vesicles<\/a>. Am J Respir Cell Mol Biol. 2019 Feb;60(2):209-220. PMID: 30230353; PMCID:\u00a0PMC6376407.<\/li>\n
  7. Guimbellot JS, Leach JM, Chaudhry IG, Quinney NL, Boyles SE, Chua M<\/strong>, Aban I, Jaspers I, Gentzsch M. Nasospheroids permit measurements of CFTR-dependent fluid transport<\/a>. JCI Insight. 2017 Nov 16;2(22). PMID: 29202459; PMCID:\u00a0PMC5752372.<\/li>\n
  8. Yu D, Davis RM, Aita M, Burns KA, Clapp PW, Gilmore RC, Chua M<\/strong>, O’Neal WK, Schlegel R, Randell SH, C Boucher R. Characterization of rat meibomian gland ion and fluid transport<\/a>. Invest Ophthalmol Vis Sci. 2016 Apr 1;57(4):2328-43. PMID: 27127933; PMCID: PMC4855829.<\/li>\n
  9. Boh\u00f3rquez EB, Chua M<\/strong>, Meshnick SR<\/span>. Quinine localizes to a non-acidic compartment within the food vacuole of the malaria parasite Plasmodium falciparum<\/a>. Malar J.<\/span> 2012 Oct 22;11(1):350. PMID: 23088166; PMCID:\u00a0PMC3520729.<\/li>\n
  10. Sears PR, Davis CW, Chua M<\/strong>, Sheehan JK. Mucociliary interactions and mucus dynamics in ciliated human bronchial epithelial cell cultures<\/a>. <\/span>Am J Physiol Lung Cell Mol Physiol<\/span>. 2011 Aug;301(2):L181-6.PMID: 21531774; PMCID:\u00a0PMC3154625.<\/li>\n
  11. Zucker RM, Chua M<\/strong>. Evaluation and purchase of confocal microscopes: numerous factors to consider<\/a>. Curr Protoc Cytom. 2010 Oct;Chapter 2:Unit2.16. PMID: 20938918.<\/li>\n
  12. Ostrowski LE, Yin W, Rogers TD, Busalacchi KB, Chua M<\/strong>, O’Neal WK, Grubb BR. Conditional deletion of dnaic1 in a murine model of primary ciliary dyskinesia causes chronic rhinosinusitis<\/a>. Am J Respir Cell Mol Biol<\/span>. 2010 Jul;43(1):55-63. PMID: 19675306; PMCID:\u00a0PMC2911571.<\/li>\n
  13. Jolly PS, Berkowitz P, Bektas M, Lee HE, Chua M<\/strong>, Diaz LA, Rubenstein DS. p38MAPK signaling and desmoglein-3 internalization are linked events in pemphigus acantholysis<\/a>. J Biol Chem<\/span>. 2010 Mar 19;285(12):8936-41. PMID: 20093368; PMCID:\u00a0PMC2838315.<\/li>\n
  14. Slade KM, Baker M, Chua M<\/strong>, Thompson NL, Pielak GJ. Effects of recombinant protein expression on green fluorescent protein diffusion in Escherichia coli<\/a>. Biochemistry. 2009 Jun 16;48(23):5083-9. PMID: 19413350; PMCID:\u00a0PMC4529995.<\/li>\n
  15. Lee HE, Berkowitz P, Jolly PS, Diaz LA, Chua MP<\/strong>, Rubenstein DS. Biphasic activation of p38MAPK suggests that apoptosis is a downstream event in pemphigus acantholysis<\/a>. J Biol Chem. 2009 May 1;284(18):12524-32. PMID: 19270308; PMCID:\u00a0PMC2673318.<\/li>\n
  16. Tuvim MJ, Mospan AR, Burns KA, Chua M<\/strong>, Mohler PJ, Melicoff E, Adachi R, Ammar-Aouchiche Z, Davis CW, Dickey BF. Synaptotagmin 2 couples mucin granule exocytosis to Ca2+ signaling from endoplasmic reticulum<\/a>. J Biol Chem. 2009 Apr 10;284(15):9781-7. PMID: 19208631; PMCID:\u00a0PMC2665099.<\/li>\n
  17. Berkowitz P, Chua M<\/strong>, Liu Z, Diaz LA, Rubenstein DS. Autoantibodies in the autoimmune disease pemphigus foliaceus induce blistering via p38 mitogen-activated protein kinase-dependent signaling in the skin<\/a>. Am J Pathol<\/span>. 2008 Dec;173(6):1628-36. PMID: 18988808; PMCID:\u00a0PMC2626375.<\/li>\n
  18. Zhang L, Theise N, Chua M<\/strong>, Reid LM. The stem cell niche of human livers: Symmetry between development and regeneration<\/a>. Hepatology. 2008 Nov;48(5):1598-607. PMID: 18972441.<\/li>\n
  19. Zucker RM, Rigby P, Clements I, Salmon W, Chua M<\/strong>. Reliability of confocal microscopy spectral imaging systems: Use of multispectral beads<\/a>. Cytometry A. 2007 Mar;71(3):174-89. PMID: 17266146.<\/li>\n
  20. Rossi AH, Salmon WC, Chua M<\/strong>, Davis CW. Calcium signaling in human airway goblet cells following purinergic activation<\/a>. Am J Physiol Lung Cell Mol Physiol.<\/span> 2007 Jan;292(1):L92-8. PMID: 16951133.<\/span><\/li>\n
  21. Berkowitz P, Hu P, Liu Z, Diaz LA, Enghild JJ, Chua MP, <\/b>Rubenstein DS. <\/b>Desmosome signaling. Inhibition of p38MAPK prevents pemphigus vulgaris<\/i> IgG-induced cytoskeleton reorganization<\/a>. J Biol Chem. 2005 Jun 24;280(25):23778-84. PMID: 15840580.<\/li>\n
  22. Perez-Vilar J, Olsen JC, Chua M<\/strong>, Boucher RC. pH-dependent intraluminal organization of mucin granules in live human mucous\/goblet cells<\/a>. J Biol Chem. 2005 Apr 29;280(17):16868-81. PMID: 15718243.<\/li>\n
  23. Vincent P, Chua M<\/strong>, Nogue F, Fairbrother A, Mekeel H, Xu Y, Allen N, Bibikova TN, Gilroy S, Bankaitis VA. A Sec14p-nodulin domain phosphatidylinositol transfer protein polarizes membrane growth of Arabidopsis thaliana root hairs<\/a>. J Cell Biol. 2005 Feb 28;168(5):801-12. PMID: 15728190; PMCID:\u00a0PMC2171805.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

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