{"id":453,"date":"2011-11-22T17:20:00","date_gmt":"2011-11-22T22:20:00","guid":{"rendered":"https:\/\/med.sites.unc.edu\/cfpulmcenter\/collaborative-opportunities\/clinical-capabilities\/measures-of-the-pulmonary-microbiome\/"},"modified":"2025-03-21T14:10:27","modified_gmt":"2025-03-21T18:10:27","slug":"measures-of-the-pulmonary-microbiome","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/marsicolunginstitute\/collaborative-opportunities\/clinical-capabilities\/measures-of-the-pulmonary-microbiome\/","title":{"rendered":"Measures of the Pulmonary Microbiome"},"content":{"rendered":"<p><!-- portlet_header --><\/p>\n<p><!-- portlet_above --><\/p>\n<p><!-- description --><\/p>\n<p>UNC has developed the capacity to measure the respiratory microbiome with 16S-454 pyrosequencing technologies (<strong>Fig. 22<\/strong>). This technique has already been applied to studies of acute exacerbations in CF and COPD and measurement of antibiotic effects.<\/p>\n<p>In sum, the Marsico Lung Institute has a diverse array of capabilities for performing first-in-man Phase I clinical studies of novel therapeutic agents and is highly motivated to perform such studies.<\/p>\n<table class=\"listing\" style=\"width: 500px\" border=\"0\">\n<tbody>\n<tr>\n<th><img loading=\"lazy\" decoding=\"async\" class=\"somoverlay alignnone\" title=\"Figure 22\" src=\"https:\/\/www.med.unc.edu\/marsicolunginstitute\/wp-content\/uploads\/sites\/547\/2017\/12\/Figure-22.png\" alt=\"Two pie charts, both under the label &quot;CF airways have a unique microbial community structure and reduced diversity compared to healthy airways.&quot; The pie chart at left is labeled &quot;CF sputum (n=50),&quot; and the pie chart at right is labeled &quot;Healthy volunteers (n=3).&quot;\" width=\"495\" height=\"370\" \/><\/th>\n<\/tr>\n<tr>\n<td>\n<p class=\" \"><span class=\"discreet\"><strong><span style=\"color: #000000\">Figure 22.<\/span> <\/strong><span style=\"color: #000000\">16S pyrosequencing analyses of human respiratory microbiome. <\/span><\/span><span class=\"discreet\" style=\"color: #000000;line-height: 1.35em\">Distribution of microbiome of CF <strong>(L)<\/strong> and normal <strong>(R)<\/strong> induced sputum as determined by 16S-454 pyrosequencing.<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<hr style=\"border-style: initial;border-color: initial\" \/>\n<h2><\/h2>\n<div><span class=\"largeFont\"><i>\u00a0<\/i><\/span><\/div>\n","protected":false},"excerpt":{"rendered":"<p>UNC has developed the capacity to measure the respiratory microbiome with 16S-454 pyrosequencing technologies (Fig. 22). This technique has already been applied to studies of acute exacerbations in CF and COPD and measurement of antibiotic effects. In sum, the Marsico Lung Institute has a diverse array of capabilities for performing first-in-man Phase I clinical studies &hellip; <a href=\"https:\/\/www.med.unc.edu\/marsicolunginstitute\/collaborative-opportunities\/clinical-capabilities\/measures-of-the-pulmonary-microbiome\/\" aria-label=\"Read more about Measures of the Pulmonary Microbiome\">Read more<\/a><\/p>\n","protected":false},"author":76119,"featured_media":0,"parent":58,"menu_order":21,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-453","page","type-page","status-publish","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Measures of the Pulmonary Microbiome | Marsico Lung Institute<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/marsicolunginstitute\/collaborative-opportunities\/clinical-capabilities\/measures-of-the-pulmonary-microbiome\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Measures of the Pulmonary Microbiome | Marsico Lung Institute\" \/>\n<meta property=\"og:description\" content=\"UNC has developed the capacity to measure the respiratory microbiome with 16S-454 pyrosequencing technologies (Fig. 22). This technique has already been applied to studies of acute exacerbations in CF and COPD and measurement of antibiotic effects. In sum, the Marsico Lung Institute has a diverse array of capabilities for performing first-in-man Phase I clinical studies &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/marsicolunginstitute\/collaborative-opportunities\/clinical-capabilities\/measures-of-the-pulmonary-microbiome\/\" \/>\n<meta property=\"og:site_name\" content=\"Marsico Lung Institute\" \/>\n<meta property=\"article:modified_time\" content=\"2025-03-21T18:10:27+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/marsicolunginstitute\/wp-content\/uploads\/sites\/547\/2017\/12\/Figure-22.png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/marsicolunginstitute\/collaborative-opportunities\/clinical-capabilities\/measures-of-the-pulmonary-microbiome\/\",\"url\":\"https:\/\/www.med.unc.edu\/marsicolunginstitute\/collaborative-opportunities\/clinical-capabilities\/measures-of-the-pulmonary-microbiome\/\",\"name\":\"Measures of the Pulmonary Microbiome | Marsico Lung Institute\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/marsicolunginstitute\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/marsicolunginstitute\/collaborative-opportunities\/clinical-capabilities\/measures-of-the-pulmonary-microbiome\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/marsicolunginstitute\/collaborative-opportunities\/clinical-capabilities\/measures-of-the-pulmonary-microbiome\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/marsicolunginstitute\/wp-content\/uploads\/sites\/547\/2017\/12\/Figure-22.png\",\"datePublished\":\"2011-11-22T22:20:00+00:00\",\"dateModified\":\"2025-03-21T18:10:27+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/marsicolunginstitute\/collaborative-opportunities\/clinical-capabilities\/measures-of-the-pulmonary-microbiome\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/marsicolunginstitute\/collaborative-opportunities\/clinical-capabilities\/measures-of-the-pulmonary-microbiome\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/marsicolunginstitute\/collaborative-opportunities\/clinical-capabilities\/measures-of-the-pulmonary-microbiome\/#primaryimage\",\"url\":\"https:\/\/www.med.unc.edu\/marsicolunginstitute\/wp-content\/uploads\/sites\/547\/2017\/12\/Figure-22.png\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/marsicolunginstitute\/wp-content\/uploads\/sites\/547\/2017\/12\/Figure-22.png\",\"width\":495,\"height\":370},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/marsicolunginstitute\/collaborative-opportunities\/clinical-capabilities\/measures-of-the-pulmonary-microbiome\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/marsicolunginstitute\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Marsico Lung Institute Accomplishments\",\"item\":\"https:\/\/www.med.unc.edu\/marsicolunginstitute\/collaborative-opportunities\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Human Phase I Clinical Studies\",\"item\":\"https:\/\/www.med.unc.edu\/marsicolunginstitute\/collaborative-opportunities\/clinical-capabilities\/\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Measures of the Pulmonary Microbiome\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/marsicolunginstitute\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/marsicolunginstitute\/\",\"name\":\"Marsico Lung Institute\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/marsicolunginstitute\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Measures of the Pulmonary Microbiome | Marsico Lung Institute","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.med.unc.edu\/marsicolunginstitute\/collaborative-opportunities\/clinical-capabilities\/measures-of-the-pulmonary-microbiome\/","og_locale":"en_US","og_type":"article","og_title":"Measures of the Pulmonary Microbiome | Marsico Lung Institute","og_description":"UNC has developed the capacity to measure the respiratory microbiome with 16S-454 pyrosequencing technologies (Fig. 22). 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