{"id":457,"date":"2011-11-22T17:20:00","date_gmt":"2011-11-22T22:20:00","guid":{"rendered":"https:\/\/med.sites.unc.edu\/cfpulmcenter\/collaborative-opportunities\/clinical-capabilities\/novel-biomarkers-for-pulmonary-drug-development\/"},"modified":"2025-03-21T14:02:26","modified_gmt":"2025-03-21T18:02:26","slug":"novel-biomarkers-for-pulmonary-drug-development","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/marsicolunginstitute\/collaborative-opportunities\/clinical-capabilities\/novel-biomarkers-for-pulmonary-drug-development\/","title":{"rendered":"Novel Biomarkers for Pulmonary Drug Development"},"content":{"rendered":"<p><!-- portlet_header --><\/p>\n<p><!-- portlet_above --><\/p>\n<p><!-- description --><\/p>\n<p><a name=\"top\"><\/a>The Marsico Lung Institute has developed a number of novel biomarkers for measuring the pharmacodynamic and therapeutic effects of inhaled therapeutic agents in sputum. Much effort has been focused on the measurement of the proper vs. improper hydration of mucus in airway diseases. Consequently, the Marsico Lung Institute has a spectrum of technologies designed to measure these parameters in induced or expectorated sputum, including measures of absolute mucin concentrations, mucin\/mucus osmotic pressure\/modulus, and measures of mucus adhesion (<strong>Fig. 21<\/strong>). In parallel, the Marsico Lung Institute has the capacity to measure a large number of classical biomarkers in sputum through our Sputum Core, including measures of cell counts, cytokines, and growth factors.<\/p>\n<table style=\"width: 495px\" border=\"0\">\n<tbody>\n<tr>\n<td valign=\"bottom\"><img loading=\"lazy\" decoding=\"async\" class=\"somoverlay alignnone\" style=\"border-width: initial;border-color: initial\" title=\"Figure 21A\" src=\"https:\/\/www.med.unc.edu\/marsicolunginstitute\/wp-content\/uploads\/sites\/547\/2017\/12\/Figure-21A.png\" alt=\"Illustrated diagram of an oncometer system\" width=\"135\" height=\"210\" \/> <img loading=\"lazy\" decoding=\"async\" class=\"alignnone\" style=\"border-width: initial;border-color: initial\" title=\"Figure 21B\" src=\"https:\/\/www.med.unc.edu\/marsicolunginstitute\/wp-content\/uploads\/sites\/547\/2017\/12\/Figure-21B.png\" alt=\"Graph with Pressure as the Y-axis and Percent Solids as the X-axis\" width=\"279\" height=\"190\" align=\"right\" \/><\/td>\n<\/tr>\n<tr>\n<td><span class=\"discreet\"><strong><span style=\"color: #000000\">Figure 21.<\/span> A.<\/strong> Custom-designed oncometer system used to measure the osmotic pressure\/moduli of human airway mucus. <strong>B.<\/strong> Summary data showing the osmotic pressure vs. mucus concentration (% solids).<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"<p>The Marsico Lung Institute has developed a number of novel biomarkers for measuring the pharmacodynamic and therapeutic effects of inhaled therapeutic agents in sputum. Much effort has been focused on the measurement of the proper vs. improper hydration of mucus in airway diseases. Consequently, the Marsico Lung Institute has a spectrum of technologies designed to &hellip; <a href=\"https:\/\/www.med.unc.edu\/marsicolunginstitute\/collaborative-opportunities\/clinical-capabilities\/novel-biomarkers-for-pulmonary-drug-development\/\" aria-label=\"Read more about Novel Biomarkers for Pulmonary Drug Development\">Read more<\/a><\/p>\n","protected":false},"author":76119,"featured_media":0,"parent":58,"menu_order":20,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-457","page","type-page","status-publish","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Novel Biomarkers for Pulmonary Drug Development | Marsico Lung Institute<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/marsicolunginstitute\/collaborative-opportunities\/clinical-capabilities\/novel-biomarkers-for-pulmonary-drug-development\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Novel Biomarkers for Pulmonary Drug Development | Marsico Lung Institute\" \/>\n<meta property=\"og:description\" content=\"The Marsico Lung Institute has developed a number of novel biomarkers for measuring the pharmacodynamic and therapeutic effects of inhaled therapeutic agents in sputum. Much effort has been focused on the measurement of the proper vs. improper hydration of mucus in airway diseases. Consequently, the Marsico Lung Institute has a spectrum of technologies designed to &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/marsicolunginstitute\/collaborative-opportunities\/clinical-capabilities\/novel-biomarkers-for-pulmonary-drug-development\/\" \/>\n<meta property=\"og:site_name\" content=\"Marsico Lung Institute\" \/>\n<meta property=\"article:modified_time\" content=\"2025-03-21T18:02:26+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/marsicolunginstitute\/wp-content\/uploads\/sites\/547\/2017\/12\/Figure-21A.png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" 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