{"id":460,"date":"2011-11-22T17:20:00","date_gmt":"2011-11-22T22:20:00","guid":{"rendered":"https:\/\/med.sites.unc.edu\/cfpulmcenter\/collaborative-opportunities\/clinical-capabilities\/radionuclide-measurements-of-mucociliary-clearance\/"},"modified":"2025-03-21T13:49:53","modified_gmt":"2025-03-21T17:49:53","slug":"radionuclide-measurements-of-mucociliary-clearance","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/marsicolunginstitute\/collaborative-opportunities\/clinical-capabilities\/radionuclide-measurements-of-mucociliary-clearance\/","title":{"rendered":"Radionuclide Measurements of Mucociliary Clearance"},"content":{"rendered":"<p><!-- portlet_header --><\/p>\n<p><!-- portlet_above --><\/p>\n<p><!-- description --><\/p>\n<p style=\"text-align: left\"><a name=\"top\"><\/a>We have had extensive experience with measuring mucociliary clearance as a function of disease status and, importantly, in response to therapeutic agents (<strong>Fig. 18<\/strong>). More recently, these techniques have been extended so that analyses of the heterogeneity of mucus transport as a function of disease status and therapeutic intervention can now be measured (<strong>Fig. 19<\/strong>).<\/p>\n<p>The inhaled radionucleotide technique can also be utilized for measurements of the total deposition and intraregional deposition of novel therapeutic agents. Thus, we have had extensive experience measuring upper airway, lower airway, and intraregional distributions of inhaled radionuclides as delivered by novel therapeutic devices. This technique is also suitable for performing bridging studies with respect to different devices delivering a common therapeutic agent.<\/p>\n<table class=\"listing\" style=\"width: 650px\" border=\"0\">\n<tbody>\n<tr>\n<th><img loading=\"lazy\" decoding=\"async\" class=\"somoverlay alignnone\" style=\"border-width: initial;border-color: initial;text-align: center\" title=\"Figure 18\" src=\"https:\/\/www.med.unc.edu\/marsicolunginstitute\/wp-content\/uploads\/sites\/547\/2017\/12\/Figure-18.png\" alt=\"A radionuclide image labeled &quot;Lung Deposition,&quot; and a graph labeled &quot;Mucociliary Clearance,&quot; with Percent Retention as the Y-axis and Time as the X-axis\" width=\"450\" height=\"200\" \/><\/th>\n<th><img loading=\"lazy\" decoding=\"async\" class=\"somoverlay alignnone\" style=\"border-width: initial;border-color: initial;text-align: center\" title=\"Figure 19\" src=\"https:\/\/www.med.unc.edu\/marsicolunginstitute\/wp-content\/uploads\/sites\/547\/2017\/12\/Figure-19.png\" alt=\"Radionucleotide image labeled &quot;Regional heterogeneity of MCC,&quot; with a scale bar labeled &quot;Fast&quot; at the top and &quot;Slow&quot; at the bottom\" width=\"250\" height=\"193\" \/><\/th>\n<\/tr>\n<tr>\n<td><span class=\"discreet\"><strong><span style=\"color: #000000\">Figure 18. <\/span>(L)<\/strong> radionuclide deposition in normal subject; <strong>(R)<\/strong> acceleration of clearance after inhaled hypertonic saline (HS).<\/span><\/td>\n<td><span class=\"discreet\"><strong><span style=\"color: #000000\">Figure 19<\/span>.<\/strong> Heterogeneity of mucus clearance in right lung of CF subject.<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>In addition to classical CT imaging techniques, we have recently advanced the utilization of MRI for investigation of pulmonary disease and therapeutics directed towards restoration of pulmonary function. Novel techniques include state-of-the-art algorithms to generate detailed structural information about the lung from MRI, utilization of measurements of blood flow to generate insights into airway plugging, and, soon, the ability to use hyperpolarized xenon to generate measurements of gas distribution to complete the characterization of the lung by this powerful, non-radiation exposing technique.<\/p>\n<p style=\"text-align: right\">[<a class=\"anchor-link\" href=\"#top\">top<\/a>]\n","protected":false},"excerpt":{"rendered":"<p>We have had extensive experience with measuring mucociliary clearance as a function of disease status and, importantly, in response to therapeutic agents (Fig. 18). More recently, these techniques have been extended so that analyses of the heterogeneity of mucus transport as a function of disease status and therapeutic intervention can now be measured (Fig. 19). &hellip; <a href=\"https:\/\/www.med.unc.edu\/marsicolunginstitute\/collaborative-opportunities\/clinical-capabilities\/radionuclide-measurements-of-mucociliary-clearance\/\" aria-label=\"Read more about Radionuclide Measurements of Mucociliary Clearance\">Read more<\/a><\/p>\n","protected":false},"author":76119,"featured_media":0,"parent":58,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-460","page","type-page","status-publish","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Radionuclide Measurements of Mucociliary Clearance | Marsico Lung Institute<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/marsicolunginstitute\/collaborative-opportunities\/clinical-capabilities\/radionuclide-measurements-of-mucociliary-clearance\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Radionuclide Measurements of Mucociliary Clearance | Marsico Lung Institute\" \/>\n<meta property=\"og:description\" content=\"We have had extensive experience with measuring mucociliary clearance as a function of disease status and, importantly, in response to therapeutic agents (Fig. 18). More recently, these techniques have been extended so that analyses of the heterogeneity of mucus transport as a function of disease status and therapeutic intervention can now be measured (Fig. 19). &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/marsicolunginstitute\/collaborative-opportunities\/clinical-capabilities\/radionuclide-measurements-of-mucociliary-clearance\/\" \/>\n<meta property=\"og:site_name\" content=\"Marsico Lung Institute\" \/>\n<meta property=\"article:modified_time\" content=\"2025-03-21T17:49:53+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/marsicolunginstitute\/wp-content\/uploads\/sites\/547\/2017\/12\/Figure-18.png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" 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