{"id":466,"date":"2011-11-22T17:20:00","date_gmt":"2011-11-22T22:20:00","guid":{"rendered":"https:\/\/med.sites.unc.edu\/cfpulmcenter\/collaborative-opportunities\/pre-clinical-capabilities-1\/animal-models-of-lung-disease\/"},"modified":"2025-03-21T13:38:42","modified_gmt":"2025-03-21T17:38:42","slug":"animal-models-of-lung-disease","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/marsicolunginstitute\/collaborative-opportunities\/pre-clinical-capabilities-1\/animal-models-of-lung-disease\/","title":{"rendered":"Animal Models of Lung Disease"},"content":{"rendered":"<p><!-- portlet_header --><\/p>\n<p><!-- portlet_above --><\/p>\n<p><!-- description --><\/p>\n<div class=\"row  oscitas-bootstrap-container\">\n<div class=\"col-lg-7 col-md-12 col-xs-12 col-sm-12 oscitas-bootstrap-container\">\n<p>The Marsico Lung Institute has numerous animal models of lung diseases, including the first \u201cCF mouse\u201d (UNC<sup>tm<\/sup> null). Current gene-targeted models include MUC1, 4, and 16<sup> &#8211;<\/sup>\/<sup>&#8211;<\/sup> mice, P2Y2-R <sup>&#8211;<\/sup>\/<sup>&#8211;<\/sup> and P2Y4-R<sup> &#8211;<\/sup>\/<sup>&#8211;<\/sup> mice, and pannexin <sup>&#8211;<\/sup>\/<sup>&#8211; <\/sup>mice.<\/p>\n<p>In addition, the Institute has the muco-obstructive \u03b2ENaC transgenic mouse. \u03b2ENaC mice have been crossed onto multiple strains and differing levels of transgene expression have developed. The mice exhibit a phenotype of airway surface liquid volume depletion, mucus hyperconcentration and adhesion, inflammation, early bacterial infection, airway re-modeling, and emphysema. \u03b2ENaC mice have been used for multiple drug studies, including ENaC blockers (<strong>Fig. 17<\/strong>), steroids, macrolides, and inhaled osmolytes.<\/div>\n<div class=\"col-lg-5 col-md-12 col-xs-12 col-sm-12 oscitas-bootstrap-container\">\n<img loading=\"lazy\" decoding=\"async\" class=\"somoverlay alignnone\" title=\"Figure 17\" src=\"https:\/\/www.med.unc.edu\/marsicolunginstitute\/wp-content\/uploads\/sites\/547\/2017\/12\/figure17.png\" alt=\"Whole histologic section images of \u03b2ENaC and wild-type mice, stained with AB-PAS\" width=\"300\" height=\"206\" \/><strong>Figure 17.<\/strong> Whole histologic sections of \u03b2ENaC and wild type (WT) mice, stained with AB-PAS. Note mucus-obstructed airway in \u03b2ENac-Tg mice (upper left). Mucus obstruction is cleared with treatment with ENaC blocker (upper right). WT controls shown below.<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; &nbsp;<\/p>\n","protected":false},"author":76119,"featured_media":0,"parent":60,"menu_order":23,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-466","page","type-page","status-publish","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Animal Models of Lung Disease | Marsico Lung Institute<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/marsicolunginstitute\/collaborative-opportunities\/pre-clinical-capabilities-1\/animal-models-of-lung-disease\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Animal Models of Lung Disease | Marsico Lung Institute\" \/>\n<meta property=\"og:description\" content=\"&nbsp; 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