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Alan Lee Hinderliter, MD

Henry A. Foscue Distinguished Professor of Medicine, Division of Cardiology

Specialty Areas

Hypertension; echocardiography; valvular heart disease; heart disease in patients with chronic kidney disease.

Education and Experience

MD: Washington University, St. Louis, 1981; Intern and Resident: University of Michigan, 1981-1984; Hypertension Fellowship: University of Michigan, 1984-1985; Cardiology Fellowship: University of North Carolina, 1985-1988; Assistant Professor of Medicine: University of North Carolina, 1988-1995; Associate Professor of Medicine: University of North Carolina, 1995-present.

Clinical and Research Interests

Dr. Hinderliter’s principal clinical interests are hypertension and echocardiography. He is a hypertension specialist and sees patients with high blood pressure that is difficult to control in the multidisciplinary UNC Hypertension Clinic. Dr. Hinderliter serves as the director of the UNC Hospitals echocardiography laboratory and provides imaging support to the structural heart disease program. He also works closely with the kidney transplant program in evaluating risk of cardiovascular events in patients who are considering a transplant.

Dr. Hinderliter’s research has focused on the effects of exercise, diet, and weight loss on high blood pressure, and on novel therapies for resistant hypertension. His research laboratory is actively engaged in studying the effects of disease processes, pharmacologic therapies, and lifestyle interventions on vascular endothelial function, and on investigating the cardiovascular manifestations of air pollution.

Selected Bibliography

Sherwood A, Hill LK, Blumenthal JA, Hinderliter AL. The Effects of Ambulatory Blood Pressure Monitoring on Sleep Quality in Men and Women With Hypertension: Dipper vs. Nondipper and Race Differences. Am J Hypertens. 2019 Jan 1;32(1):54-60.

Blumenthal JA, Sherwood A, Smith PJ, Hinderliter A. The Role of Salt Reduction in the Management of Hypertension. J Am Coll Cardiol. 2018 Apr 10;71(14):1597-1598.

Sherwood A, Smith PJ, Hinderliter AL, Georgiades A, Blumenthal JA. Effects of exercise and stress management training on nighttime blood pressure dipping in patients with coronary heart disease: A randomized, controlled trial. Am Heart J. 2017 Jan;183:85-90.

Blumenthal JA, Sherwood A, Smith PJ, Watkins L, Mabe S, Kraus WE, Ingle K, Miller P, Hinderliter A. Enhancing Cardiac Rehabilitation With Stress Management Training: A Randomized, Clinical Efficacy Trial. Circulation. 2016;133(14):1341-50.

Hinderliter AL, Sherwood A, Craighead LW, Lin PH, Watkins L, Babyak MA, Blumenthal JA. The long-term effects of lifestyle change on blood pressure: One-year follow-up of the ENCORE study. Am J Hypertens. 2014;27(5):734-741.

Fihn SD, Gardin JM, Abrams J, Berra K, Blankenship JC, Dallas AP, Douglas PS, Foody JM, Gerber TC, Hinderliter AL, King SB, 3rd, Kligfield PD, Krumholz HM, Kwong RY, Lim MJ, Linderbaum JA, Mack MJ, Munger MA, Prager RL, Sabik JF, Shaw LJ, Sikkema JD, Smith CR, Jr., Smith SC, Jr., Spertus JA, Williams SV, Anderson JL. 2012. ACCF/AHA/ACP/AATS/PCNA/SCAI/STS guideline for the diagnosis and management of patients with stable ischemic heart disease: a report of the American College of Cardiology Foundation/American Heart Association task force on practice guidelines. Circulation. Dec 18 2012;126(25):e354-471. See also J Am Coll Cardiol. 2012;60(24):e44-e164.

Blumenthal JA, Babyak MA, Sherwood A, Craighead L, Lin PH, Johnson J, Watkins LL, Wang JT, Kuhn C, Feinglos M, Hinderliter A. Effects of the dietary approaches to stop hypertension diet alone and in combination with exercise and caloric restriction on insulin sensitivity and lipids. Hypertension. 2010;55(5):1199-1205.

Schneider A, Neas L, Herbst MC, Case M, Williams RW, Cascio W, Hinderliter A, Holguin F, Buse JB, Dungan K, Styner M, Peters A, Devlin RB. Endothelial dysfunction: associations with exposure to ambient fine particles in diabetic individuals. Environ Health Perspect. 2008;116(12):1666-1674.

Hinderliter AL, Blumenthal JA, O’Conner C, Adams KF, Dupree CS, Waugh RA, Bensimhon D, Christenson RH, Sherwood A. Independent prognostic value of echocardiography and N-terminal pro-B- type natriuretic peptide in patients with heart failure. Am Heart J. 2008;156(6):1191-1195.

Sherwood A, Bower JK, McFetridge-Durdle J, Blumenthal JA, Newby LK, Hinderliter AL. Age moderates the short-term effects of transdermal 17beta-estradiol on endothelium-dependent vascular function in postmenopausal women. Arterioscler Thromb Vasc Biol. 2007;27(8):1782-1787.

Blumenthal JA, Sherwood A, Babyak MA, Watkins LL, Waugh R, Georgiades A, Bacon SL, Hayano J, Coleman RE, Hinderliter A. Effects of exercise and stress management training on markers of cardiovascular risk in patients with ischemic heart disease: a randomized controlled trial. JAMA. 2005;293(13):1626-1634.

Hinderliter AL, Willis PWt, Barst RJ, Rich S, Rubin LJ, Badesch DB, Groves BM, McGoon MD, Tapson VF, Bourge RC, Brundage BH, Koerner SK, Langleben D, Keller CA, Murali S, Uretsky BF, Koch G, Li S, Clayton LM, Jobsis MM, Blackburn SD, Jr., Crow JW, Long WA. Effects of long-term infusion of prostacyclin (epoprostenol) on echocardiographic measures of right ventricular structure and function in primary pulmonary hypertension. Primary Pulmonary Hypertension Study Group. Circulation. 1997;95(6):1479-1486.

Dr. Alan Hinderliter