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Alena Janda Markmann, MD, PhD

Assistant Professor

Specialty

Infectious Diseases, Virology, Viral Immunology, Antibody Structure

Education

BS: magna cum laude, University of Rochester, 2007; MD, PhD: Albert Einstein College of Medicine, 2015; Resident: Mount Sinai Hospital & Health System, 2015-2017; Infectious Diseases Fellow: University of North Carolina, 2017-2020

Employment

Clinical Instructor: University of North Carolina, 2020-2021; Assistant Professor of Medicine: University of North Carolina 2021-present

Clinical Interests

My clinical passion is caring for individuals suffering from all types of infectious diseases across a broad clinical spectrum. Seeing and taking care of patients is very rewarding and gives me an important perspective of the patient and healthcare side of medicine that I can apply to my research projects. As a clinician scientist, I have developed a research interest in the morbidity and global public health burden of new and emerging viruses. My current research interests include studying human immune responses to Zika and dengue viruses, with a specific focus on B cell and antibody responses.

Selected Bibliography

Graham SD, Tu HA, McElvany BD, Graham NR, Grinyo A, Davidson E, Doranz BJ, Diehl SA, de Silva AM, Markmann AJ. A Novel Antigenic Site Spanning Domains I and III of the Zika Virus Envelope Glycoprotein Is the Target of Strongly Neutralizing Human Monoclonal Antibodies. J Virol. 2021 Apr 12;95(9).

Hou YJ, Chiba S, Halfmann P, Ehre C, Kuroda M, Dinnon KH 3rd, Leist SR, Schäfer A, Nakajima N, Takahashi K, Lee RE, Mascenik TM, Graham R, Edwards CE, Tse LV, Okuda K, Markmann AJ, Bartelt L, de Silva A, Margolis DM, Boucher RC, Randell SH, Suzuki T, Gralinski LE, Kawaoka Y, Baric RS. SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo. Science. 2020 Dec 18;370(6523):1464-1468.

Mateus J, Grifoni A, Tarke A, Sidney J, Ramirez SI, Dan JM, Burger ZC, Rawlings SA, Smith DM, Phillips E, Mallal S, Lammers M, Rubiro P, Quiambao L, Sutherland A, Yu ED, da Silva Antunes R, Greenbaum J, Frazier A, Markmann AJ, Premkumar L, de Silva A, Peters B, Crotty S, Sette A, Weiskopf D. Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans. Science. 2020 Oct 2;370(6512):89-94.

Premkumar L, Segovia-Chumbez B, Jadi R, Martinez DR, Raut R, Markmann A, Cornaby C, Bartelt L, Weiss S, Park Y, Edwards CE, Weimer E, Scherer EM, Rouphael N, Edupuganti S, Weiskopf D, Tse LV, Hou YJ, Margolis D, Sette A, Collins MH, Schmitz J, Baric RS, de Silva AM. The receptor binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients. Sci Immunol. 2020 Jun 11;5(48).

Janda A, Bowen A, Greenspan NS, Casadevall A. Ig Constant Region Effects on Variable Region Structure and Function. Front Microbiol. 2016;7:22.

Janda A, Eryilmaz E, Nakouzi A, Pohl MA, Bowen A, Casadevall A. Variable Region Identical IgA and IgE to Cryptococcus neoformans Capsular Polysaccharide Manifest Specificity Differences. J Biol Chem. 2015 May 8;290(19):12090-100.

Janda A, Eryilmaz E, Nakouzi A, Cowburn D, Casadevall A. Variable region identical immunoglobulins differing in isotype express different paratopes. J Biol Chem. 2012 Oct 12;287(42):35409-35417. doi: 10.1074/jbc.M112.404483. Epub 2012 Aug 28.

Casadevall A, Janda A. Immunoglobulin isotype influences affinity and specificity. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12272-3.

Abboud N, Chow SK, Saylor C, Janda A, Ravetch JV, Scharff MD, Casadevall A. A requirement for FcγR in antibody-mediated bacterial toxin neutralization. J Exp Med. 2010 Oct 25;207(11):2395-405.

Wedekind JE, Gillilan R, Janda A, Krucinska J, Salter JD, Bennett RP, Raina J, Smith HC. Nanostructures of APOBEC3G support a hierarchical assembly model of high molecular mass ribonucleoprotein particles from dimeric subunits. J Biol Chem. 2006 Dec 15;281(50):38122-6.

Recognitions and Honors

UNC Physician Scientist Training Award, September 2020

Alena Janda, MD, PhD
  • Infectious Diseases