Amanda E. Nelson, MD, MSCR, RhMSUS

Associate Professor of Medicine, Division of Rheumatology, Allergy and Immunology

Specialty Areas: general rheumatology, rheumatoid arthritis, spondyloarthropathies, osteoarthritis, crystalline arthropathies, polymyalgia rheumatica, musculoskeletal ultrasound, epidemiology

Chronology: BA Magna Cum Laude, Studio Art: The Colorado College, 1997; MD: Vanderbilt University Medical Center, 2002; Internal Medicine Internship: University of South Alabama, 2002-2003; Nuclear Medicine Residency: Northwestern University, 2003-2004; Internal Medicine Residency: Virginia Mason Medical Center, 2004-2006; Rheumatology Fellowship: University of North Carolina, 2006-2009; Clinical Assistant Professor of Medicine: University of North Carolina, 2009-2013; Assistant Professor of Medicine: University of North Carolina, 2013-2019; Associate Professor of Medicine: University of North Carolina, 2019-present.

Description of research and/or clinical interests: Dr. Nelson is a board-certified internist and rheumatologist with a Masters in Clinical Research in epidemiology. She has a half day per week general rheumatology clinic as well as a half day musculoskeletal ultrasound clinic, and is involved in fellow education. Dr. Nelson’s research is focused on a variety of aspects of imaging in osteoarthritis (OA), including the contribution of bone shape to OA risk, novel methodologies for analysis of imaging data, and assessment of whole-body burden of OA. She has also done work involving serum biomarkers of OA, and investigated racial and gender differences in imaging and other aspects of OA.

Selected Bibliography:

Updates to selected bibliography:

  1. Nelson AE. Turning the page in osteoarthritis assessment with the use of ultrasound. Curr Rheumatol Rep 2020; 22(10):66, doi: 10.1007/s11926-020-00949-w.
  2. Yerich NV, Alvarez C, Schwartz TA, Savage-Guin S, Renner JB, Bakewell CJ, Kohler MJ, Lin J, Samuels J, Nelson AE. A standardized, pragmatic approach to knee ultrasound for clinical research in osteoarthritis: The Johnston County Osteoarthritis Project. ACR Open Rheumatol 2020;2(7):438-48. Doi: 10.1002/acr2.11159. (PMC in process)
  3. Van Spil WE, Bierma-Zienstra SMA, Deveza LA, Arden NK, Bay-Jensen AC, Kraus VB, Carlesso L, Christensen R, van der Esch M, Kent P, Knoop J, Ladel C, Little CB, Loeser RF, Losina E, Mills K, Mobasheri A, Nelson AE, Neogi T, Peat GM, Rat AC, Steultjens M, Thomas MJ, Valdes AM, Hunter DJ. A consensus-based framework for conducting and reporting osteoarthritis phenotype research. Arthritis Res Ther 2020;22(1):54. Doi: 10.1186/s13075-020-2143-0. [PMC7083005]
  4. Arbeeva L, Nelson AE, Alvarez C, Cleveland RJ, Allen KD, Golightly YM, Jordan JM, Callahan LF, Schwartz TA. Application of traditional and emerging methods for the joint longitudinal analysis of repeated measurements with time-to-event outcomes in Rheumatology. Arthritis Care Res 2020;72(5):615-21. doi: 10.1002./acr.23881. [PMC6761043]
  5. Snyder EA, Alvarez C, Golightly YM, Renner JB, Jordan JM, Nelson AE. Incidence and progression of hand osteoarthritis in a large community-based cohort: the Johnston County Osteoarthritis Project. Osteoarthritis Cartilage 2020;28(4):446-52. doi: 10.1016/j.joca.2020.02.028. [NIHMS1568768]
  6. Edwards K, Leyland KM, Sanchez-Santos MT, Arden CP, Spector TD, Nelson AE, Jordan JM, Nevitt M, Hunter DJ, Arden NK. Differences between race and sex in measures of hip morphology: a population-based comparative study.  Osteoarthritis Cartilage 2020;28(2):189-200. doi: 10.1016/j.joca.2019.10.014. [NIHMS1549353]
  7. Kolasinski S, Neogi T, Hochberg MC, Oatis C, Guyatt G, Block J, Callahan L, Copenhaver C, Dodge C, Felson D, Gellar K, Harvey WF, Hawker G, Herzig E, Kwoh CK, Nelson AE, Samuels J, Scanzello C, White D, Wise B, Altman RD, DiRenzo D, Fontanarosa J, Giradi G, Ishimori M, Misra D, Shah AA, Shmagel AK, Thoma LM, Turgunbaev M, Turner AS, Reston J. 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip and Knee. Arthritis Rheumatol 2020;72(2):220-233. doi: 10.1002/art/41142.
  8. Alvarez C, Cleveland RJ, Schwartz TA, Renner JB, Murphy LB, Jordan JM, Callahan LF, Golightly YM, Nelson AE. Comorbid conditions and the transition among states of hip osteoarthritis and symptoms in a community-based study: A multi-state time-to-event model approach. Arthritis Res Ther 2020;22(1):12. doi: 10.1186/s13075-020-2101-x. [PMC6972032]
  9. Deveza LA, Nelson AE, Loeser RF. Phenotypes of osteoarthritis – current state and future implications. Clin Exp Rheumatol 2019;37(5, sup 120):64-72. [PMC6936212]
  10. Cleveland RJ, Nelson AE, Callahan LF. Knee and hip osteoarthritis as predictors of premature death: a review of the evidence. Clin Exp Rheumatol 2019;37(5, sup 120):24-30). [PMC6934074]
  11. Nelson AE, Fang F, Arbeeva L, Cleveland RJ, Schwartz TA, Callahan LF, Marron JS, Loeser RF. A machine learning approach to knee osteoarthritis phenotyping: Data from the FNIH Biomarkers Consortium. Osteoarthritis Cartilage 2019;27(7):994-1001. doi: 10.1016/j.joca.2018.12.027 [PMC6579689]
  12. Gullo TR, Golightly YM, Flowers P, Jordan JM, Renner JB, Schwartz TA, Kraus VB, Hannan MT, Cleveland RJ, Nelson AE. Joint hypermobility is not positively associated with prevalent multiple joint osteoarthritis: a cross-sectional analysis in older adults.  BMC Musculoskel Dis 2019;20:165. doi: 10.1186/s12891-019-2550-z. [PMC6460832]
  13. Goode AP, Cleveland RJ, Schwartz TA, Nelson AE, Kraus VB, Hillstrom HJ, Hannan MT, Flowers P, Renner JB, Jordan JM, Golightly YM. Relationship of joint hypermobility with low back pain and lumbar spine osteoarthritis. BMC Musculoskel Dis 2019:20:158. doi: 10.1186/s12891-019-2523-2. [PMC6456963]
  14. Gullo TR, Golightly YM, Cleveland RJ, Renner JB, Callahan LF, Jordan JM, Kraus VB, Nelson AE. Defining multiple joint osteoarthritis, its frequency and impact in a community-based cohort.  Sem Arthritis Rheum 2019;48(6):950-7. doi: 10.1016/j.semarthrit.2018.10.001 [PMC6456431]
  15. Corsi M, Alvarez, C, Callahan, LF, Cleveland, R, Golightly, YM, Jordan, JM, Nelson, AE, Renner, J, Tsai, A, Allen, KD. Contributions of symptomatic osteoarthritis and physical function to incident cardiovascular disease. BMC Musculoskel Dis 2018;19(1):393. doi: 10.1186/s12891-018-2311-4 [PMC6230250]
  16. Golightly YM, Hannan M, Nelson AE, Hillstrom H, Cleveland RJ, Kraus VB, Schwartz TA, Goode AP, Flowers P, Renner JB, Jordan JM. Relationship of joint hypermobility with ankle and foot radiographic osteoarthritis and symptoms in a community-based cohort. Arthritis Care Res 2019;71(4):538-44. doi: 10.1002/acr.23686. [PMC6310667]
  1. Longobardi L, Jordan JM, Shi XA, Renner JB, Schwartz TA, Nelson AE, Barrow DA, Kraus VB, Spagnoli A. Associations between the chemokine biomarker CCL2 and knee osteoarthritis outcomes: The Johnston County Osteoarthritis Project. Osteoarthritis Cartilage 2018;26(9):1257-61. doi:10.1016/j.joca.2018.04.012. [PMC6098742]
  2. Nelson AE. The importance of hip shape in predicting hip osteoarthritis. Curr Treat Options in Rheum 2018;4(2):214-22, doi 10.1007/s40674-018-0096-0. [PMC6269115]
  3. Flowers P, Cleveland RJ, Schwartz TA, Nelson AE, Kraus VB, Hillstrom H, Goode AP, Hannan M, Renner JB, Jordan JM, Golightly YM. Association of general joint hypermobility and knee, hip, and lumbar spine osteoarthritis by race: a cross-sectional study. Arthritis Res Ther 2018;20(1):76, doi:10.1186/s13075-018-1570-7. [PMC5907300]
  4. Nelson AE. Osteoarthritis year in review 2017: clinical. Osteoarthritis Cartilage 2018;26(3):319-25, doi: 10.1016/j.joca.2017.11.014. [PMC5835411]
  5. Raveendran R, Stiller JL, Alvarez C, Renner JB, Schwartz TA, Arden NK, Jordan JM, Nelson AE. Population-based prevalence of radiographic features of femoroacetabular impingement: The Johnston County Osteoarthritis Project.  Osteoarthritis Cartilage 2018;26(1):54-61, doi: 10.1016/j.joca.2017.10.002. [PMC5732866]
  6. Goode A, Nelson AE, Kraus VB, Renner JB, Jordan JM. Biomarkers reflect differences in osteoarthritis phenotypes of the lumbar spine: The Johnston County Osteoarthritis Project. Osteoarthritis Cartilage 2017;25(10):1672-9. [PMC5605465]
  7. Nelson AE, Golightly YM, Lateef S, Renner JB, Jordan JM, Aspden RM, Hillstrom H, Gregory JS. Cross-sectional associations between variations in ankle shape by statistical shape modeling, injury history, and race: The Johnston County Osteoarthritis Project. J Foot Ankle Res, 2017;10:34, doi: 10.1186/s13047-017-0216-3. [PMC5530536]
  8. Qin J, Barbour KE, Murphy LB, Nelson AE, Schwartz TA, Helmick CG, Allen KD, Renner JB, Baker NA, Jordan JM. Lifetime Risk of Symptomatic Hand Osteoarthritis: The Johnston County Osteoarthritis Project. Arthritis Rheumatol 2017;69(6):1204-12, doi: 10.1002/art.40097. [PMC5449255]
  9. Lateef S, Golightly YM, Renner JB, Jordan JM, Nelson AE. A cross-sectional analysis of radiographic ankle osteoarthritis frequency and associated factors: The Johnston County Osteoarthritis Project. J Rheumatol 2017;44:499-504. [PMC5468490]
  10. Meneses SR, Goode AP, Nelson AE, Lin J, Allen KD, Bennell KL, Jordan JM, Fernandes L, Liu S, Hochberg MC, Underwood M, Conaghan PG, Lohmander S, McAlindon TE, Golightly YM, Hunter DJ. Clinical algorithms to aid osteoarthritis guideline dissemination. Osteoarthritis Cartilage 2016;24(9):1487-99, doi: 10.1016/j.joca.2016.04.004.
  11. Nelson AE, Golightly YM, Renner JB, Schwartz TA, Liu F, Lynch JA, Gregory JS, Aspden RM, Lane NE, Jordan JM. Variations in hip shape are associated with radiographic knee osteoarthritis: The Johnston County Osteoarthritis Project.  J Rheumatol 2016;43(2):405-10, doi: 10.3899/jrheum.150559. [PMC4738023]
  12. An, H, Marron JS, Schwartz TA, Renner JB, Liu F, Lynch JA, Lane NE, Jordan JM, Nelson AE. Novel statistical methodology reveals that hip shape is associated with incident radiographic hip osteoarthritis among African American women. Osteoarthritis Cartilage 2016;24(4):640-6, doi: 10.1016/j.joca.2015.11.013. [PMC4799754]

 

Select Listing of Prior Publications Includes:

Nelson AE, Stiller JL, Shi XA, Leyland KM, Renner JB, Schwartz TA, Arden NK, Jordan JM. Measures of hip morphology are related to development of worsening radiographic hip osteoarthritis over 6 to 13 year follow-up: the Johnston County Osteoarthritis Project. Osteoarthritis Cartilage. 2015 Oct 20. pii: S1063-4584(15)01357-6. doi: 10.1016/j.joca.2015.10.007. [Epub ahead of print]

Ogdie A, Shah AA, Makris UE, Jiang Y, Nelson AE, Kim AHJ, Angeles-Han S, Castelino FV, Golding A, Muscal E, Kahlenberg JM, Barg FK. Barriers and Facilitators of a Career as a Physician Scientist Among Rheumatologists in the United States. Arthritis Care Res 2015;67(9):1191-1201, doi: 10.1002/acr.22569.

Golightly YM, Allen KD, Nyrop KA, Nelson AE, Callahan LF, Jordan JM. Patient-reported outcomes to initiate a provider-patient dialog for the management of hip and knee osteoarthritis. Semin Arthritis Rheum 2015;45(2):123-31, doi: http://dx.doi.org/10.1016/j.semarthrit.2015.04.008.

Lane NE, Hochberg MC, Nevitt MC, Simon LS, Nelson AE, Doherty M, Herontin Y, Flechsenhar K. OARSI Clinical Trials Recommendations: Design and conduct of clinical trials for hip osteoarthritis. Osteoarthritis Cartilage 2015;23(5):761-771, doi: 10.1016/j.joca.2015.03.006.

Kloppenburg M, Maheu E, Kraus VB, Cicuttini F, Doherty M, Dreiser RL, Henrotin Y, Jiang GL, Mandl L, Martel-Pelletier J, Nelson AE, Neogi T, Pelletier JP, Punzi L, Ramonda R, Simon LS, Wang S. OARSI Hand Clinical Trial Recommendations Work Group. OARSI Clinical Trials Recommendations: Design and conduct of clinical trials for hand osteoarthritis. Osteoarthritis Cartilage 2015;23(5):772-786. doi: 10.1016/j.joca.2015.03.007.

Doré AL, Golightly YM, Mercer VS, Shi XA, Renner JB, Jordan JM, Nelson AE. Lower Limb Osteoarthritis and the Risk of Falls in a Community-Based Longitudinal Study of Adults with and without Osteoarthritis. Arthritis Care Res 2015;67(5):633-9, doi: 10.1002/acr.22499. [PMC4404178]

Aslam I, Perjar I, Shi XA, Renner JB, Kraus VB, Golightly YM, Jordan JM, Nelson AE. Associations Between Biomarkers of Joint Metabolism, Hand Osteoarthritis, and Hand Pain and Function: The Johnston County Osteoarthritis Project. J Rheumatol 2014;41(5):938-44, doi: 10.3899/jrheum.130904. [PMC4008682]

Nelson AE, Allen KD, Golightly YM, Goode AP, Jordan JM. A systematic review of recommendations and guidelines for the management of osteoarthritis: The Chronic Osteoarthritis Management Initiative of the U.S. Bone and Joint Initiative. Semin Arthritis Rheum 2014;43:701-12, doi: 10.1016/j.semarthrit.2013.11.012. [PMC n/a]

Nelson AE, Smith MW, Golightly YM, Jordan JM. “Generalized Osteoarthritis”: A Systematic Review. Semin Arthritis Rheum 2014;43:713-20, doi: 10.1016/j.semarthrit.2013.12.007. [PMC4065634]

Golightly YM, Devellis RF, Nelson AE, Hannan MT, Lohmander LS, Renner JB, Jordan JM. Psychometric properties of the foot and ankle outcome score in a community-based study of adults with and without osteoarthritis. Arthritis Care Res 2014, epub 9/10/13, doi: 10.1002/acr.22162. [PMC4211630]

Nelson AE, Liu F, Lynch JA, Renner JB, Schwartz TA, Lane, NE, Jordan JM. Incident symptomatic hip osteoarthritis is associated with differences in hip shape by active shape modeling: The Johnston County Osteoarthritis Project. Arthritis Care Res 2014;66(1):74-81. DOI: 10.1002/acr.22094 [PMC3959908]

Nelson AE, Elstad E, DeVellis RF, Schwartz TA, Golightly YM, Renner JB, Conaghan PG, Kraus VB, Jordan JM. Composite measures of multi-joint symptoms, but not of radiographic osteoarthritis, are associated with functional outcomes: The Johnston County Osteoarthritis Project. Dis Rehab 2014,36(4):300-6, epub 5/3/13, doi:10.3109/09638288.2013.790490. [PMC3735714]

Nelson AE, Golightly YM, Renner JB, Schwartz TA, Kraus VB, Helmick CG, and JM Jordan. Differences in multijoint symptomatic osteoarthritis phenotypes by race and sex: The Johnston County Osteoarthritis Project. Arthritis Rheum 2013;65(2):373-7. [PMC3558926]

Nelson AE, DeVellis RF, Renner JB, Schwartz TA, Conaghan PG, Kraus VB, and JM Jordan. Quantification of the whole-body burden of radiographic osteoarthritis using factor analysis. Arthritis Res Ther 2011;13:R176, doi:10.1186/ar3501 [open access].

Nelson AE, Renner JB, Schwartz TA, Kraus VB, Helmick CG, and JM Jordan. Differences in multi-joint radiographic osteoarthritis phenotypes among African Americans and Caucasians: The Johnston County Osteoarthritis Project. Arthritis Rheum 2011;63(12):3843-52, doi 10.1002/art.30610 [PMC3227756].

Nelson AE, Chaudhary S, Kraus VB, Fang F, Chen JC, Schwartz TA, Shi XA, Renner JB, Stabler TV, Helmick CG, Caldwell KL, Poole AR, Jordan JM. Whole blood lead levels are associated with biomarkers of joint tissue metabolism in African American and White men and women: The Johnston County Osteoarthritis Project. Env Res 2011;111:1208-14, doi:10.1016/j.envres.2011.08.002 [PMC3210895].

Nelson AE, Shi XA, Schwartz TA, Chen JC, Renner JB, Caldwell KL, Helmick CG, Jordan JM. Whole blood lead levels are associated with knee symptoms and radiographic knee osteoarthritis: A cross-sectional analysis in the Johnston County Osteoarthritis Project. Arthritis Res Ther 2011;13:R37, doi:10.1186/ar3270 [open access].

Nelson AE, Renner JB, Shi XA, Shreffler JH, Schwartz TA, and JM Jordan. Cross-sectional comparison of extended anteroposterior and posteroanterior fixed-flexion positioning to assess radiographic osteoarthritis at the knee: The Johnston County Osteoarthritis Project. Arthritis Care Res 2010;62(9):1342-5 [PMC2939919].

Nelson AE, Golightly YM, Kraus VB, Stabler T, Renner JB, Helmick CG, and JM Jordan. Serum transforming growth factor-beta 1 is not a robust biomarker of incident and progressive radiographic osteoarthritis at the hip and knee: The Johnston County Osteoarthritis Project. Osteoarthritis Cartilage 2010; 18:825-9 [PMC2873050].

Nelson AE, Braga L, Renner JB, Atashili J, Woodard J, Hochberg MC, Helmick CG, Jordan JM. Characterization of individual radiographic features of hip osteoarthritis in African Americans and Whites: The Johnston County Osteoarthritis Project. Arthritis Care Res 2010;62(2):190-7 [PMC2846079].

Nelson AE, Braga L, Braga-Baiak A, Atashili J, Schwartz TA, Renner JB, Helmick CG, and JM Jordan. Static knee alignment measurements among Caucasians and African-Americans: The Johnston County Osteoarthritis Project. J Rheumatol 2009;36(9):1987-90 [PMC2853360].

Nelson AE, Fang F, Shi XA, Kraus VB, Stabler T, Renner JB, Helmick CG, and JM Jordan. Failure of serum transforming growth factor-beta (TGF-β) as a biomarker of radiographic osteoarthritis (rOA) at the knee and hip: a cross-sectional analysis in the Johnston County Osteoarthritis Project. Osteoarthritis Cartilage 2009;17:772-6 [PMC2746496].

Jordan JM, Helmick CG, Renner JB, Luta G, Dragomir AD, Woodard J, Fang F, Schwartz TA, Nelson AE, Abbate LM, Callahan LF, Kalsbeek WD, and MC Hochberg. Prevalence of hip symptoms and radiographic and symptomatic hip osteoarthritis in African-Americans and Caucasians: The Johnston County Osteoarthritis Project. J Rheumatol 2009;36(4):809-15 [PMC2957092].

 

To View A More Comprehensive List of Publications by Dr. Nelson: Use This Link

 

 

  • Phone Number

    (984) 974-4191 (Appointments)

  • Addresses

    Office: Thurston Arthritis Research Center

    3300 Thurston Building

    Box 7280

    Chapel Hill, NC 27599-7280
  • Clinic Location: Carolina Pointe II

    6013 Farrington Rd #301

    Chapel Hill, NC 27517