Areas of Interest
Clinical: Advanced Heart Failure, Cardio-oncology
Research: myocardial biology, alpha-1 adrenergic receptors, kinase inhibitor cardiotoxicity, cardiomyocyte mitochondrial function and metabolism
I am a physician-scientist with a clinical and investigative focus on heart failure. I have subspecialty clinical certification in Advanced Heart Failure/Transplantation and serve as an attending physician on the UNC Heart Failure/Transplant/LVAD inpatient service. I also direct the UNC cardio-oncology clinic.
My laboratory uses basic and translational approaches to study heart failure and the molecular response to myocardial injury. The primary projects in my laboratory focus on (1) Understanding how alpha-1A adrenergic receptors adaptively regulate cardiomyocyte metabolism and developing an alpha-1A adrenergic receptor agonist to treat heart failure; (2) Determining the mechanisms underlying cardiotoxicity of cytotoxic and targeted cancer therapies; and (3) Identifying cardioprotective roles for the nuclear receptor ROR-alpha in regulating cardiomyocyte metabolism and inflammation.
Education and Training
Cardiology Fellowship: University of California, San Francisco, Ca
Residency: Brigham and Women’s Hospital, Boston, MA
Medical School: University of North Carolina at Chapel Hill, Chapel Hill, NC
Undergraduate: Pomona College, Claremont, CA