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Bonner Professor of Medicine, Division of Pulmonary Diseases and Critical Care Medicine

546 EPA Research Facility

Specialty Areas: Asthma

Chronology: BS: Queens College, Flushing, NY (1949); MD: Harvard Medical School (1953); Residency: Peter Bent Brigham Hospital, Boston, MA (1960); Fellowship: Mt Sinai Hospital, New York, NY; Research Fellow: Harvard Medical School, Peter Bent Brigham, Boston, MA

Selected Bibliography:

Alexis, N., M. Eldridge, W. Reed, Bromberg PA, D. Peden. CD14-Dependent airway PMN response to inhaled LPS: Role of Atopy. J Allergy Clin Immunology 107:31-5, 2001.

Samet J.M., G.E. Hatch, D. Horstman, S.E. Steck, L. Arab, Bromberg, PA , M. Levine, R.B. Devlin. Effect of antioxidant supplementation on ozone-induced lung injury in human subjects. Am. J. Respir. Crit. Care Med., 164:819-825, 2001.

Johnson T.A., R.B. Devlin., A.J. Ghio, Y-C T. Huang, D.L. Costa, C.L. Engle, Bromberg, PA, W.E. Cascio. Cardiopulmonary effects of nebulized residual oil fly ash in anesthetized pigs. In INIS Monograph Series-Crucial Issues in Inhalation Research – Mechanistic, Clinical and Epidemiologic. U. Heinrich and U. Mohr, eds, Fraunhofer IRB Verlag, Stuttgart, Germany, 2002, pg 199-212.

Riediker M., R. Williams, R. Devlin, T. Griggs, Bromberg PA. Exposure to particulate matter, volatile organic compounds, and other air pollutants inside patrol cars. Environ. Sci. Technol. 37:2084-2093, 2003.

Hazucha M.J., L.J. Folinsbee, Bromberg PA. Distribution and reproducibility of spirometric response to ozone by gender and age. J. Appl. Physiol 85:1917-1925, 2003.

Boehlecke B., M. Hazucha, D. Peden, R. Jacobs, N. Alexis, P. Reist, P.A. Bromberg. Low-dose endotoxin enhances bronchial responsiveness to inhaled allergen in atopic asthmatics. J. Allergy Clin. Immunol, 112:1241-3, 2003.

Wu W., J.M. Samet, Silbajoris R., Dailey L., Sheppard D. P.A. Bromberg . Graves L. Heparin-binding EGF cleavage mediates zinc-induced EGF receptor phosphorylation. Am J Respir Cell Molec Biol. 30:540-7, 2004.

Riediker M., Cascio W., Griggs T., Herbst M., P.A. Bromberg, Neas L., Williams R., Devlin R. Particulate matter exposure in cars is associated with cardiovascular effects in healthy young men. Am. J. Resp.Crit. Care Med. 169:934-40, 2004.

Alexis N.E., S. Becker, P.A. Bromberg, R.B. Devlin, D.B. Peden. Circulating CD11b expression correlates with the neutrophil response and airway mCD14 expression is enhanced following ozone exposure in humans. Clin.Immunol 111:126-31, 2004.

Riediker M., R.B. Devlin, T.R. Griggs, M.C. Herbst, P.A. Bromberg, R.W. Williams, W.E. Cascio. Cardiovascular effects in patrol officers are associated with fine particulate matter from brake wear and engine emissions. Particle and Fibre Toxicology 1:2, 2004.

Riediker M, M. Herbst, R. Devlin, T. Griggs, P. Bromberg, W. Cascio. Effect of the September 11, 2001 Terrorist attack on a state highway patrol trooper’s heart rate variability. Ann Noninvasive Electrocardiol. 10 (1): 83-85, 2005.

Alexis, N., J.C. Lay, M. Almond, P.A. Bromberg, D. Patel, D.B. Peden. Acute LPS inhalation in healthy volunteers induces dendritic cell maturation in vivo. Journal of Allergy and Clinical Immunology, 115:345-350, 2005.

Wu W., R.A. Silbajoris, Y.E. Whang, L.M. Graves, P.A. Bromberg, J.M. Samet. p38 and EGF receptor Kinase-mediated Activation of the Phosphatidylinositol 3-kinase/Akt Pathway Is Required for Zn2+-induced Cyclooxygenase-2 Expression. Am J Physiol Lung Cell Mol Physiol, 289:L883-L889, 2005.

Selgrade MK, R.F. Lemanske, M.Ian Gilmour, L.M. Neas, M. Ward, P.K. Henneberger, D.N. Weissman, J.A. Hoppin, R.R. Dietert, P.D. Sly, A.M. Geller, P.L. Enright, G.S. Backus, P.A. Bromberg, D. Germolec, K.B. Yeatts. “Induction of asthma and the environment: What we know and need to know”. Environmental Health Perspectives. 114:615-619, 2006.

Lay, J.C., N.E. Alexis, R.R. Kleeberger, R.A.S. Roubey, B.D. Harris, Bromberg PA, M.J. Hazucha, R.B. Devlin, D.B. Peden. Ozone enhances markers of innate immunity and antigen presentation on airway monocytes in healthy individuals. J. Allergy Clin Immunol. 120(3):719-22, 2007.

Kim Y-M, Cao D, Reed W, Wu W, Jaspers I, Tal T, Bromberg PA, Graves LM, Samet J. Zn2+-induced NF-kappaB-dependent transcriptional activity involves site-specific p65/RelA phosphorylation. Cell Signal. 19:538-546, 2007.

Cao D, Tal TL, Graves LM, Gilmour MI, Linak W, Reed W, Bromberg PA, Samet JM. Diesel exhaust particulate (DEP)-induced activation of Stat3 requires activities of EGFR and Src in airway epithelial cells. Am J Physiol Lung Cell Mol Physiol, 292:422-429, 2007.

Wu W., Alexis N.E., Chen X., Bromberg P.A., Peden D.B. Involvement of c-Jun N-terminal kinase and NFkB in LPS-induced CD40 expression on human monocytic cells. Toxicology Appl. Pharm. 228(2):135-143, 2008.

Wu W., Silbajoris R., Cao D., Bromberg P.A., Zhang Q., Peden D.B., Samet J.M. Regulation of Cyclooxygenase-2 expression by cAMP response element and mRNA stability in zinc-exposed human airway epithelial cells. Toxicol Appl Pharmacol 231(2):260-266, 2008.

Tal T.L., Bromberg P.A., Kim Y.M., Samet J.A. Epidermal growth factor receptor activation by diesel particles is mediated by tyrosine phosphatase inhibition. Toxicol. Appl. Pharmacol 233:382-8, 2008.

Wu W, NE Alexis, Bromberg P.A., I Jaspers, and DB Peden. Mechanisms of LPS-induced CD40 expression in human peripheral blood monocytes. Biochem Biophys Res Commun. 379:573-577, 2009.

Zhou H, Alexis N.E., Donohue J., LaForce C, Bromberg P.A., Peden D.B. Influence of C-159T SNP of CD14 gene promoter on lung function in smokers with chronic bronchitis. Respiratory Medicine, In press (2009).

Samet JM, Rappold A, Graff D, Cascio WE, Berntsen JH, Huang YC, Herbst M, Bassett M, Montilla T, Hazucha MJ, Bromberg PA, Devlin RB. Concentrated Ambient Ultrafine Particle Exposure Induces Cardiac Changes in Young Healthy Volunteers. Am J Respir Crit Care Med. 2009 Feb 20. [Epub ahead of print]

Cao D, Bromberg PA, Samet JM. Diesel particle-induced transcription expression of p21 involves activation of EGFR, SRC and STATз. American Journal of Respiratory Cell and Molecular Biology 2009 Mar 21. [Epub ahead of print]

Philip Bromberg, MD