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Catherine Callaghan Coombs, MD

Assistant Professor of Medicine, Division of Hematology

Specialty Areas

Myeloid and lymphoid leukemias, including acute myeloid leukemia, acute promyelocytic leukemia, myelodysplastic syndromes, myeloproliferative neoplasms, MDS/MPN overlap syndromes such as chronic myelomonocytic leukemia, chronic lymphocytic leukemia/small lymphocytic lymphoma, prolymphocytic leukemia, large granular lymphocytic leukemia, and hairy cell leukemia.


Assistant Professor, University of North Carolina, Department of Medicine, Division of Hematology/Oncology, 2016-present; Fellowship, Memorial Sloan Kettering Cancer Center, 2013-2016, Hematology/Oncology; Residency, Duke University Medical Center, 2010-2013, Internal Medicine; Doctor of Medicine, University of Cincinnati College of Medicine, 2010; Master’s Degree, University of Cincinnati, 2006, Bio-Analytical Chemistry; Bachelor’s Degree, Saint Louis University, 2004.

Research and Clinical Interests

Dr. Coombs’s research interests center on the application of genomic correlates to improve the clinical care of patients with leukemia. She has performed research to better understand the genetic risk factors leading to the development of chronic lymphocytic leukemia. Additionally, she has characterized of a large cohort of solid tumor patients in whom clonal hematopoiesis has been identified on “matched normal” blood sequencing data obtained on next-generation sequencing to assess for associations between clonal hematopoiesis, prior cytotoxic therapy, and impact on long term outcomes such as development of subsequent hematologic malignancy and overall survival. She also has an interest in the application of molecularly-targeted agents to the treatment of patients with hematologic malignancies.

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