Skip to main content

Associate Professor of Medicine, Division of Pulmonary Diseases and Critical Care Medice

Specialty Areas: Critical care medicine, respiratory failure, ARDS, sepsis, medical emergency teams, asthma, COPD

Chronology: BS: Stanford University, 1994; MD: University of Michigan, 1998; Resident: University of North Carolina, 1998-2001; Hospitalist: Rex Hospital, 2001-2002; Pulmonary and Critical Care Fellow: University of North Carolina, 2002-2005; Assistant Professor of Medicine: University of South Carolina 2005-2007; Assistant Professor of Medicine: University of North Carolina, 2007-present; Medical Director: University of North Carolina Resuscitation Teams 2011-present; Medical Director: University of North Carolina Medical ICU 2013- present.

Dr. Chang’s research interests include looking at the overall outcomes of critical illness in both the general population as well as specific patient subpopulations such as those patients with advanced malignancy, understanding the outcomes of patients requiring medical emergency team interventions and the association with the process metrics of hospital rapid response team services, evaluation of specific management strategies in the treatment of patients with acute respiratory distress syndrome (ARDS). She is also clinically involved in the care of patients with general pulmonary disease.

Selected Bibliography:

Hulett CS(1), Pathak V, Katz JN, Montgomery SP, Chang LH. Development and preliminary assessment of a critical care ultrasound course in an adult pulmonary and critical care fellowship program. Annals of the American Thoracic Society. 2014 Jun;11(5):784-8.

Austin CA, Hanzaker C, Culp L, Mayer C, Stafford R, Chang LH. Utilization of Rapid Response Resources and Outcomes in a Comprehensive Cancer Center. Critical Care Medicine. 2013 Dec 19

Chang, LH, Rivera MP. Respiratory diseases: meeting the challenges of screening, prevention, and treatment. North Carolina Medical Journal. 2013. Sep-Oct;74(5):385-92.

Lobo LJ, Chang LC, Esther CR Jr, Gilligan PH, Tulu Z, Noone PG. Lung transplant outcomes in cystic fibrosis patients with pre-operative Mycobacterium abscessus respiratory infections. Clinical Transplant. 2013 Jul-Aug;27(4):523-9.

Needham DM, Dinglas VD, Bienvenu OJ, Colantuoni E, Wozniak AW, Rice TW, Hopkins RO; NIH NHLBI ARDS Network. One year outcomes in patients with acute lung injury randomised to initial trophic or full enteral feeding: prospective follow-up of EDEN randomised trial. British Medical Journal. 2013 Mar 19;346. (Site co-investigator)

National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network, Rice TW, Wheeler AP, Thompson BT, Steingrub J, Hite RD, Moss M, Morris A, Dong N, Rock P. Initial trophic vs full enteral feeding in patients with acute lung injury: the EDEN randomized trial. JAMA. 2012 Feb 22;307(8):795-803. (Site co-investigator).

Kangelaris KN, Sapru A, Calfee CS, Liu KD, Pawlikowska L, Witte JS, Vittinghoff E, Zhuo H, Auerbach AD, Ziv E, Matthay MA; National Heart, Lung, and Blood Institute ARDS Network. The association between a Darc gene polymorphism and clinical outcomes in African American patients with acute lung injury. Chest. 2012 May;141(5):1160-9. (Site co-investigator)

Rice TW, Wheeler AP, Thompson BT, deBoisblanc BP, Steingrub J, Rock P; NIH NHLBI Acute Respiratory Distress Syndrome Network of Investigators. Enteral omega-3 fatty acid, gamma-linolenic acid, and antioxidant supplementation in acute lung injury. JAMA. 2011 Oct 12;306(14):1574-81. (Site co-investigator)

National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network, Matthay MA, Brower RG, Carson S, Douglas IS, Eisner M, Hite D, Holets S, Kallet RH, Liu KD, MacIntyre N, Moss M, Schoenfeld D, Steingrub J, Thompson BT. Randomized, placebo-controlled clinical trial of an aerosolized β₂-agonist for treatment of acute lung injury. American Journal of Respiratory and Critical Care Medicine. 2011 Sep 1;184(5):561-8. (Site co-investigator)

Das AM, Sood N, Hodgkin K, Chang LH, Carson SS. Developing of a triage protocol for patient presenting with gastrointestinal hemorrhage: a prospective cohort study. Critical Care. 2008; 12(2): R(57).

Chang LH, Honiden S, Short K, Haithcock J, Nierman D, Carson SC. Utilization of Inhaled Bronchodilators in Mechanically Ventilated Patients without Obstructive Lung Disease. Respiratory Care. 2007 Feb; 52(2): 154-8.

Chalermskulrat W, Sood N, Neuringer IP, Hecker TM, Chang L, Rivera MP, Paradowski LJ, Aris RM. Non-tuberculous mycobacteria in end stage cystic fibrosis: implications for lung transplantation. Thorax. 2006 Jun; 61(6): 507-13.

Carson SS, Kress JP, Rodgers JE, Vinayak A, Campbell-Bright S, Levitt J, Bourdet S, Ivanova A, Henderson A, Pohlman A, Chang LH, Rich PB, Hall J. A Randomized Trial of Intermittent Lorazepam versus Propofol with Daily Interruption in Mechanically Ventilated Patients. Critical Care Medicine. 2006 May; 34(5): 1326-32


No profile image on file