M. Leigh Anne Daniels, MD MPH

Clinical Instructor, Division of Pulmonary Diseases and Critical Care Medicine

Specialty Areas: non-CF bronchiectasis, cystic fibrosis, non-tuberculous mycobacterial infections of the lung, primary ciliary dyskinesia

Chronology: BA: La Salle University, Philadelphia, PA (2002); MD: Rutgers New Jersey Medical School, Newark, NJ (2002-2006); MPH:Rutgers School of Public Health, Newark, NJ (Biostatistics & Epidemiology) (2002-2006)
Internship and Residency: University of Rochester, Rochester, NY (Internal Medicine/Pediatrics) (2006-2010) Fellowship: University of North Carolina, Chapel Hill, NC (Pulmonary and Critical Care Medicine) (2010-2013)

Dr. Daniels has an interest in the diagnosis and management of patients with all causes of bronchiectasis, including cystic fibrosis and primary ciliary dyskinesia. Extending from her clinical experience with these patients, her research focuses on discovering the genetic variations that contribute to the development of idiopathic bronchiectasis (or bronchiectasis without a known cause). These patients have a characteristic body type; individuals often have scoliosis and/or sternal abnormalities, mitral valve prolapse, and are very flexible. They are frequently infected with non-tuberculous mycobacterium, and many have family members with bronchiectasis. She is part of the research endeavors of the Genetic Disorders of Mucociliary Clearance Consortium and the Bronchiectasis Research Registry.

Selected Bibliography:

  1. Daniels MLA, Leigh MW, Davis SD, Armstrong MC, Carson JL, Hazucha M, Dell SD, Eriksson M, Collins FS, Zariwala MA. Founder mutation in RSPH4A identified in patients of Hispanic descent with Primary Ciliary Dyskinesia. Hum Mutat. 34:1352-1356, 2013.
  2. Knowles MR, Daniels LA, Davis SD, Zariwala MA, Leigh MW. Primary ciliary dyskinesia: Recent advances in diagnostics, genetics, and characterization of clinical disease. Am J Respir Crit Care Med. 188(8):913-922, 2013.
  3. Antony D, Becker-Heck A, Zariwala MA, Schmidts M, Onoufriadis A, Forouhan M, Wilson W, Taylor-Cox T, Dewar A, Jackson C, Goggin P, Loges NT, Olbrich H, Jaspers M, Jorissen M, Leigh MW, Wolf WE, Daniels MLA, Noone P, Ferkol TW, Sagel SD, Rosenfeld M, Rutman A, Dixit A, O’Callaghan C, Lucas JS, Hogg C, Scambler PJ, Emes RD, UK10K, Chung EMK, Shoemark A, Knowles MR, Omran H, Mitchison HM. Mutations in CCDC39 and CCDC40 are the major cause of primary ciliary dyskinesia with axonemal disorganization and absent inner dynein arms. Human Mutat.34:462-472, 2013.
  4. Daniels MLA & Noone PG. Genetics, diagnosis and future treatment strategies for primary ciliary dyskinesia. Expert Opinion on Orphan Drugs. 3(1):31-44, 2015.
  5. Daniels ML, Lowe JR, Roy P, Patrone MV, Conyers JM, Fine JP, Knowles MR, Birchard KR. Standardization and validation of a novel and simple method to assess lumbar dural sac size. Clin Radiol. 70(2):146-52, 2015.

Abstracts

  1. Daniels MLA. The diagnostic dilemma of primary ciliary dyskinesia: Experience of the GDMCC. Conference on Clinical Research for Rare Diseases Oral Presentation, Bethesda, MD; September 2010.
  2. Daniels MLA. Distant recurrence of Burkholderia cepacia complex in cystic fibrosis patients following lung transplantation. North American Cystic Fibrosis Conference Adult Pulmonary Fellows Case Conference, Baltimore, MD; October 2010.
  3. Daniels MLA, Baker B, Leigh M, Knowles M. The diagnostic dilemma of primary ciliary dyskinesia: Experience of the GDMCC Consortium. Primary Ciliary Dyskinesia and Overlapping Syndromes Conference Poster Session, St. Louis, MO; October 2010.
  4. Daniels MLA, Baker B, Olson C, Dell C, Ferkol T, Milla C, Olivier K, Rosenfeld M, Sagel S, Leigh M, Davis S, Knowles M. Airflow obstruction in small airways in primary ciliary dyskinesia. Primary Ciliary Dyskinesia and Overlapping Syndromes Conference Poster Session, St. Louis, MO; October 2010.
  5. Daniels MLA, Baker B, Minnix S, Dell S, Ferkol T, Milla CE, Olivier KN, Rosenfeld M, Sagel SD, Carson JL, Davis SD, Leigh M, Knowles MR. The diagnostic dilemma of primary ciliary dyskinesia: Findings and experience of the Genetic Disorders of Mucociliary Clearance Consortium. American Thoracic Society International Conference Poster Session, Denver, CO; May 2011.
  6. Daniels MLA. Idiopathic Bronchiectasis and Connective Tissue Fibrillinopathies: Dural Ectasia as a Marker of a Distinct Bronchiectasis Subgroup. Conference on Clinical Research for Rare Diseases Oral Presentation, Bethesda, MD; October 2012.
  7. Daniels MLA, Conyers J, Lowe J, Birchard K, Knowles MR. Idiopathic Bronchiectasis And Connective Tissue Fibrillinopathies: Dural Ectasia As A Marker Of A Distinct Bronchiectasis Subgroup. American Thoracic Society International Conference Mini-Symposium Oral Presentation, Philadelphia, PA; May 2013.
  8. Smith CC, Prevots DR, Adjemian J, Seitz A, Daniels MLA, Czaja CA, Milla C, Hall DA, Holland SM, Knowles MR, Olivier KN. Characterization of idiopathic bronchiectasis in patients with and without pulmonary nontuberculous mycobacterial disease. American Thoracic Society International Conference Poster Session, Philadelphia, PA; May 2013.
  9. Daniels MLA, Conyers J, Lowe J, Birchard K, Knowles MR. Idiopathic Bronchiectasis and Connective Tissue Fibrillinopathies: Dural Ectasia As A Marker Of A Distinct Bronchiectasis Subgroup. Visiting Pulmonary Scholar Symposium Poster Presentation, Chapel Hill, NC; May 2013.
  10. Daniels MLA, Patrone MV, Conyers JM, Lowe J, Richards KE, Birchard K, Knowles MR. Dural Ectasia on Lumbosacral MRI and Chest CT in Idiopathic Bronchiectasis Patients: Phenotypic Overlap with Hereditable Connective Tissue Disorders. American Thoracic Society International Conference Oral Presentation, San Diego, CA; May 2014.
  11. Daniels MLA, Wolf W, Olivier KN, Holland SM, Zariwala MA, Knowles MR. Looking For Zebras, Finding An Okapi: Correcting A Rare Disease Diagnosis (RAG1 Deficiency). American Thoracic Society International Conference Poster Presentation, San Diego, CA; May 2014.
Mary Leigh Anne (“Leigh Anne”) Daniels, MD, MPH