Skip to main content

Erica Sparkenbaugh, PhD

Assistant Professor

Assistant Professor of Medicine, Division of Hematology

Specialty Areas

Mouse models of sickle cell disease, drug-induced liver injury, and endotoxemia. 

Education and Experience

BS Cum Laude: Allegheny College, 2005PhD (Pharmacology and Toxicology): Michigan State University, 2011Postdoctoral Fellowship: University of North Carolina, 2011-2016Research Associate: University of North Carolina, 2016-2019; Assistant Professor of Medicine: University of North Carolina 2019-present. 

Research and Clinical Interests

I am interested in studying the cross-talk between coagulation and inflammation in various animal models of disease, including sickle cell disease, thrombosis, and drug-induced liver injury. My current focus is to target the coagulation cascade and protease activated receptors to reduce the incidence and severity of vaso-occlusive crisis in sickle cell disease. Another area of interest is determining the role of the intrinsic coagulation cascade in the pathophysiology and end-organ damage associated with sickle cell disease.  

Selected Bibliography

Sparkenbaugh EM, Chen C, Brzoska T, Nguyen J, Wang S, Vercellotti G, Key NS, Sundd P, Belcher J, and Palwinski R. Thrombin-mediated activation of PAR-1 contributes to microvascular stasis in mouse models of sickle cell disease. Blood. 2020. DOI: 10.1182/bloo,2019003543. 

Sparkenbaugh EM, Chantrathammachart P, Chandarajoti K, Mackman N, Key NS, and Pawlinski R. Blood. 127(10): 1371. 2016. 

Sparkenbaugh EM, Chantrathammachart P, Mickelson J, van Ryn J, Hebbell R, Monroe DM, Mackman N, Key NS, Pawlinski R. Blood. 123(11): 1747. 2014. 

View Publications

Erica Sparkenbaugh, PhD