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Erin Steinbach, MD, PhD

Assistant Professor of Medicine & Instructor, Division of Rheumatology, Allergy and Immunology

Clinical areas of expertise: food allergy, peanut allergy, allergic rhinitis, asthma, atopic dermatitis, stinging insect allergy, drug allergy, drug desensitization, allergen immunotherapy, eosinophilic disorders, chronic idiopathic urticaria and angioedema, hereditary and acquired angioedema, mast cell disorders, primary immunodeficiency, secondary immunodeficiency.

Research areas of expertise: food allergy, peanut allergy, gastrointestinal allergy, gastrointestinal inflammation

Chronology: Education: BA Magna Cum Laude: Gustavus Adolphus College, 2005; PhD in Microbiology and Immunology: University of North Carolina at Chapel Hill, 2013; MD: University of North Carolina at Chapel Hill, 2015; Internal Medicine Resident: University of North Carolina Hospitals, 2015-2017; Allergy and Immunology Fellow: University of North Carolina Hospitals, 2017-2021; Assistant Professor of Medicine: University of North Carolina at Chapel Hill, 2021-present.

Description of research and/or clinical interests: Dr. Steinbach’s clinical interests center primarily on food allergy, peanut allergy, allergen immunotherapy, and eosinophilic disorders. Her core research interests include peanut allergy, food allergy, eosinophilic gastrointestinal disease (EGID), and gastrointestinal dysfunction in food allergy.

Selected Bibliography:

Steinbach EC, Smeekens JM, Roy S, Toyonaga T, Cornaby C, Perini LB, Berglind AE, Kulis MD, Kim EH, Ferris MT, Furey TS, Burks AW, Sheikh SZ. Increased intestinal permeability in an orally-reactive peanut allergy model identifies Angiopoietin like-4 as a biomarker. J Clin Invest. [Under review]

Toyonaga T, Araba KC, Kennedy MM, Keith BP, Wolber EA, Beasley C, Steinbach EC, Schaner MR, Jain A, Long MD, Barnes EL, Herfarth HH, Isaacs KL, Hansen JJ, Kapadia MR, Guillem JG, Gulati AS, Sethupathy P, Furey TS, Ehre C, Sheikh SZ. Increased colonic expression of ACE2 associates with poor prognosis in Crohn’s disease. Sci Rep. 2021 Jun 29;11(1):13533. doi: 10.1038/s41598-021-92979-2. PubMed PMID: 34188154; PubMed Central PMCID: PMC8241995.

Smeekens JM, Johnson-Weaver BT, Hinton AL, Azcarate-Peril MA, Moran TP, Immormino RM, Kesselring JR, Steinbach EC, Orgel KA, Staats HF, Burks AW, Mucha PJ, Ferris MT, Kulis MD. Fecal IgA, Antigen Absorption, and Gut Microbiome Composition Are Associated With Food Antigen Sensitization in Genetically Susceptible Mice. Front Immunol. 2020;11:599637. doi: 10.3389/fimmu.2020.599637. eCollection 2020. PubMed PMID: 33542716; PubMed Central PMCID: PMC7850988.

Toyonaga T, Steinbach EC, Keith BP, et al. Decreased Colonic Activin Receptor-Like Kinase 1 Disrupts Epithelial Barrier Integrity in Patients With Crohn’s Disease. Cell Mol Gastroenterol Hepatol. 2020;10(4):779-796. doi: 10.1016/j.jcmgh.2020.06.005. Epub 2020 Jun 16. PubMed PMID: 32561494; PubMed Central PMCID: PMC7502566.

Steinbach EC, Hernandez M, Dellon ES. Eosinophilic Esophagitis and the Eosinophilic Gastrointestinal Diseases: Approach to Diagnosis and Management. J Allergy Clin Immunol Pract. 2018 Sep – Oct;6(5):1483-1495. doi: 10.1016/j.jaip.2018.06.012. Epub 2018 Jul 3. PubMed PMID: 30201096; PubMed Central PMCID: PMC6134874.

Steinbach EC, Kobayashi T, Russo SM, et al. Innate PI3K p110δ regulates Th1/Th17 development and microbiota-dependent colitis. J Immunol. 2014 Apr 15;192(8):3958-68. doi: 10.4049/jimmunol.1301533. Epub 2014 Mar 14. PubMed PMID: 24634494; PubMed Central PMCID: PMC3992276.

Steinbach EC, Plevy SE. The role of macrophages and dendritic cells in the initiation of inflammation in IBD. Inflamm Bowel Dis. 2014 Jan;20(1):166-75. doi: 10.1097/MIB.0b013e3182a69dca. Review. PubMed PMID: 23974993; PubMed Central PMCID: PMC4098861.

 

Full Publication List: https://www.ncbi.nlm.nih.gov/myncbi/erin.steinbach.1/bibliography/public/