Escher Howard-Williams, MD

Assistant Professor of Medicine, Division of Hospital Medicine

Specialty Areas

Hospital medicine and Continuous Quality Improvement

Chronology

MA: University of North Carolina, 2000; MD: University of North Carolina School of Medicine, 2005; Intern: Internal Medicine, University of North Carolina, 2005-2006; Reseident: Internal Medicine, University of North Carolina, 2006-2008; Hospitalist: Internal Medicine, Rex Healthcare, 2008-2009; Hospitalist: Internal Medicine, University of North Carolina, 2009-present.

Research Interests

Dr. Howard-Williams’ current research interests primarily focus on salivary protein detection through microarray for facilitating field diagnostics. Clinically, her interests include continuous quality improvement within the department of medicine. Her main focus is addressing the current state of health care delivery and improving process management, patient safety and hospital efficiency. She has competed several Quality Improvement projects within the department of hospital medicine and continues to advance her training by completing specialized CQI training. Presently, she is sponsoing several active CQI projects within the department.

Bibliography

Bencharit S, Howard-Williams, Morton CL, Potter PM, Redinbo MR. (Poster Presentation). The “Side Door” Proposal: Structure and Function of a Rabbit Liver Carboxylesterase. International Association for Dental Research (IADR) Annual Meeting, March 2002, San Diego, CA. Journal of Dental Research (Special Issue) 2002;81:A504.

Bencharit S, Howard-Williams, Morton CL, Potter PM, Redinbo MR. Cancer Drug Activation by Liver Carboxylesterase (Poster Presentation). American Crystallographic Association Annual Meeting, July 2001, Los Angles, CA. American Crystallographic Association, INC. 2001;80:630.

Bencharit S, Howard-Williams, Morton CL, Potter PM, Redinbo MR. Cancer Drug Activation by Carboxylesterase: A Structural Study (Poster Presentation). International Association for Dental Research (IADR) Annual Meeting, June 2001, Chiba, Japan Journal of Dental Research (Special Issue) 2001;80:630.

Bencharit S, Howard-Williams, Morton CL, Potter PM, Redinbo MR. The Structural Basis of Cancer Drug Activation by Carboxylesterases (Poster Presentation). The 29th Annual Mid-Atlantic Protein Crystallography Meeting, May 2001, Williamsburg, VA.

Bencharit S, Howard-Williams, Morton CL, Potter PM, Redinbo MR. Structural basis of cancer drug activation by carboxylesterase (Poster Presentation) University of North Carolina, Chapel Hill, School of Medicine: Structural Biology and Bioinformatics Conference, March 2001, Sheraton Chapel Hill Hotel, Chapel Hill, NC.

Bencharit S, Howard-Williams, Morton CL, Potter PM, Redinbo MR. Carboxylesterases and their roles activation in camptothecin and other compounds (Poster Presentation). Triangle Biophysic Symposium, October 2000, Durham, NC.

PUBLICATIONS

Bencharit S, Baxter SS, Carlson J, Byrd WC, Mayo MV, Border MB, Kohltfarber H, Urrutia E, Howard-Williams EL, Offenbacher S, Wu MC, Buse JB. Salivary proteins associated with hyperglycemia in diabetes: a proteomic analysis. Mol Biosyst, DOI:10.1039/C3MB70196D. Manuscript accepted for publication (Aug 29, 2013; Published online Sept 4, 2013).

Bencharit S, Howard-Williams EL, Mack CR. Recent Studies and Patents in Salivary Protein Biomarkers for Diabetes. Recent Patents Biomarkers. 2012;2:1-5

Bencharit S, Reside GJ, Howard-Williams EL. Complex prosthodontic treatment with dental implants for a patient with polymyalgia rheumatica: A clinical report. Int J Maxillofac Implants. 2010;25:1241-5.

Bencharit S, Cui CB, Siddiqui A, Howard-Williams EL, Sondek J, Zuobi-Hasona, K, Aukhil I. Structural insights into fibronectin type III domain mediated signaling. J. Mol. Biol. 2007:367; 303-9.

Howard-William EL, Keys N. Case Study: Complete Factor V Deficiency. In progress. 2007

Bencharit S, Edwards CC, Morton CL, Howard-Williams EL, Kuhn P, Potter PM, Redinbo MR. Multisite promiscuity in the processing of endogenous substrates by human carboxylesterase 1. J. Mol. Biol. 2006;363:201-14.

Fleming CD, Bencharit S, Edwards CC, Hyatt JL, Tsurkan L, Bai F, Fraga C, Morton CL, Howard-Williams EL, Potter PM, Redinbo MR. Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil. J. Mol. Biol. 2005;352:165-77.

Bencharit S, Morton CL, Howard-Williams EL, Danks MK, Potter PM, Redinbo MR. Structural insights into CPT-11 activation by mammalian carboxylesterases. Nat. Struct. Biol. 2002;9:337-42.

  • Address

    101 Manning Dr. CB # 7085

    Chapel Hill, NC 27599-7085