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Assistant Professor of Medicine, Division of Pulmonary Diseases and Critical Care Medicine

Specialty Areas: ARDS, lung infection

Chronology: BA: Harvard College (1998); PhD: Massachusetts Institute of Technology (2005); MD: Harvard Medical School (2007); Internship: Johns Hopkins University School of Medicine (2007-2008); Residency: Johns Hopkins University School of Medicine (2008-2010); PCCM Fellowship: Johns Hopkins University School of Medicine (2010-2014)

Dr. Hagan’s lab studies host defense mechanisms in respiratory infections, with a focus on macrophage signaling pathways in influenza infection. We use a combination of mouse genetics, cell biology, and protein biochemistry to understand how macrophages contribute to both pathogen control and tissue damage.

Selected Bibliography:

  1. Sigmon JS, Blanchard MW, Baric RS, Bell TA, Brenna J, Brockmann GA, Burks AW, Calabrese JM, Caron KM, Cheney RE, Ciavatta D, Conlon F, Darr DB, Faber J, Franklin C, Gershon TR, Gralinski L, Gu B, Gaines CH, Hagan RS, Heimsath EG, Heise MT, Hock P, Ideraabdullah F, Jennette JC, Kafri T, Kashfeen A, Kelada S, Kulis M, Kumar V, Linnertz C, Livraghi-Butrico A, Lloyd K, Loeser R, Lutz C, Lynch RL, Magnuson T, Matsushima GK, McMullan R, Miller R, Mohlke KL, Moy SS, Murphy C, Najarian M, O’Brien L, Palmer AA, Philpot BD, Randell S, Reinhold L, Ren Y, Rockwood S, Rogala AR, Saraswatula A, Sasseti CM, Schisler JC, Schoenrock SA, Shaw G, Shorter JR, Smith CM, St. Pierre CL, Tarantino LM, Threadgill DW, Valdar W, Vilen BJ, Wardwell K, Whitmire JK, Williams L, Zylka M, Ferris MT, McMillan L, Pardo-Maneul de Villena F. Content and performance of the MiniMUGA genotyping array, a new tool to improve rigor and reproducibility in mouse research. Genetics, accepted Sept 15, 2020
  2. Hedrick TL, Murray BP, Hagan RS, Mock JR. COVID-19: Clean up on IL-6. Am J Respir Cell Mol Biol. 2020 Aug 4; DOI 10.1165/rcmb.2020-0277LE PMID: 32750259
  3. Polidoro RB, Hagan RS, de Santis Santiago R, Schmidt NW. Overview: Systemic inflammatory response derived from lung injury caused by SARS-CoV-2 infection explains severe outcomes in COVID-19. Frontiers in Immunology. 2020 Jun 26;11:1626.10.3389/fimmu.2020.01626. PMID 32714336
  4. Mock JR, Tune MK, Dial C, Torres-Castillo J, Hagan RS, Doerschuk CM. Effects of IFN-γ on immune cell kinetics during the resolution of acute lung injury. Physiological Reports Feb 2020 Physiological Reports Feb 2020, DOI 10.14814/phy2.14368 PMID 3261190
  5.  Antonia RJ, Castillo J, Herring LE, Serafin DS, Liu R, Grave LM, Baldwin AS, Hagan RS. TBK1 Limits mTORC1 by promoting phosphorylation of Raptor Ser877. Sci. Rep. 2019 Sep 17;9(1):13470. DOI: 10.1038/s41598-019-49707-8; PMID: 31530866
  6. Mock JR, Dial CS, Tune MK, Norton DL, Martin JR, Gomez JC, Hagan RS, Dang H, Doerschuk CM. Transcriptional Analysis of Foxp3+ Regulatory T Cells during Resolution of Acute Lung Injury, in revision JCI Insight 2019 Mar 21;4(6). pii: 124958. doi: 10.1172/jci.insight.124958. eCollection 2019 Mar 21. PMID 30753170
  7. Hagan RS, Torres-Castillo J, Doerschuk CM. Myeloid TBK1 signaling contributes to the immune response to influenza. Am J Respir Cell Mol Biol. 2019 Mar;60(3):335-345 ePub 2018 Oct 5  PMID 30290124
  8. Gomez JC, Dang H, Kanke M, Hagan RS, Mock JR, Kelada SNP, Sethupathy P, Doerschuk CM.  Predicted effects of observed changes in the mRNA and microRNA transcriptome of lung neutrophils during S. pneumoniae pneumonia in mice.  Sci Rep. 2017 Sep 12;7(1):11258. PMID:28900269
  9. Sellers, SA, Hagan RS, Hayden F, Fischer WA 2nd. The Hidden Burden of Influenza: Extra-Pulmomary Complications of Influenza Infection.  Influenza and Other Respiratory Viruses. 2017 Sep;11(5):372-393. PMID: 28745014 
  10. Chornoguz O, Hagan RS, Haile A, Arwood ML, Gamper CJ, Banerjee A, Powell JD. mTORC1 Promotes T-bet Phosphorylation to Regulate Th1 Differentiation. J Immunology. 2017 May 15;198(10):3939-3948. PMID: 28424242
  11. Black KE, Collins SL, Hagan RS, Hamblin MJ, Chan-Li Y, Hallowell RW, Powell JD,Horton MR. Hyaluronan fragments induce IFNbeta via a novel TLR4-TRIF-TBK1-IRF3-dependent pathway. J Inflamm (Lond). 2013 May 30;10(1):23. PMID: 23721397
  12. Hagan RS, Powell JD. Targeted immunosuppression: No longer naïve. Clin Immunol. 2012 Feb;142(2):95-6. PMID: 22079331
  13. Hagan RS, Manak MS, Buch HK, Meier MG, Meraldi P, Shah JV, Sorger PK. p31(comet) acts to ensure timely spindle checkpoint silencing subsequent to kinetochore attachment. Mol Biol Cell. 2011 Nov; 22(22):4236-46. PMID: 21965286
  14. Mapelli M, Fillip FV, Rancati G, Massimiliano L, Nezi L, Stier G, Hagan RS, Confalonieri S, Piatti S, Sattler M, Musacchio A. Determinants of conformational dimerization of Mad2 and its inhibition by p31comet. EMBO J. 2006 Mar 22;25(6):1273-84. PMID: 16525508
  15. Hagan RS, Sorger PK. Cell biology: The more MAD, the merrier.  Nature.  2005 Mar 31; 434(7033):575-7. PMID: 15800607