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Professor of Medicine, Division of Hematology and Oncology
Director, UNC Comprehensive Sickle Cell Disease program

Specialty Areas:

SIckle Cell Disease and erythropoiesis

Education and Experience:

BA Magna Cum Laude: CWRU, 1980; MD: CWRU, 1985 (Pathology externship 1984); Clinical Instructor and Assistant Professor: University of Minnesota, 1990-2000; Research Associate: NIH (NIDDK and NHLBI). 2001-2006; Assistant Professor of Medicine: Einstein, 2006-2011; Associate Professor and Professor of Medicine: CWRU, 2011-2018; Professor of Medicine: University of North Carolina, 2018-present.

Personal Statement:

I look after people with Sickle Cell Disease. I am active nationally with other hematologists in trying to improve care and management of people with Sickle Cell Disease.

Selected Bibliography:

Yuan C, Quinn E, Kucukal E, Kapoor S, Gurkan UA, Little JA. Priapism, hemoglobin desaturation, and red blood cell adhesion in men with sickle cell anemia. Blood Cells Mol Dis. 2019 Nov;79:102350. doi: 10.1016/j.bcmd.2019.102350. Epub 2019 Aug 5. PubMed PMID: 31404907; PubMed Central PMCID: PMC6744332.

Lanzkron S, Little J, Field J, Shows JR, Wang H, Seufert R, Brooks J, Varadhan R, Haywood C Jr, Saheed M, Huang CY, Griffin B, Frymark S, Piehet A, Robertson D, Proudford M, Kincaid A, Green C, Burgess L, Wallace M, Segal J. Increased acute care utilization in a prospective cohort of adults with sickle cell disease. Blood Adv. 2018 Sep 25;2(18):2412-2417. doi: 10.1182/bloodadvances.2018018382. PubMed PMID: 30254105; PubMed Central PMCID: PMC6156885.

Kucukal E, Ilich A, Key NS, Little JA, Gurkan UA. Red Blood Cell Adhesion to Heme-Activated Endothelial Cells Reflects Clinical Phenotype in Sickle Cell Disease. Am J Hematol. 2018 Jun 15;. doi: 10.1002/ajh.25159. [Epub ahead of print] PubMed PMID: 29905377; PubMed Central PMCID: PMC6295270.

Rodgers-Melnick SN, Pell TJG, Lane D, Jenerette C, Fu P, Margevicius S, Little JA. The effects of music therapy on transition outcomes in adolescents and young adults with sickle cell disease. Int J Adolesc Med Health. 2017 Aug 5;. doi: 10.1515/ijamh-2017-0004. [Epub ahead of print] PubMed PMID: 28779565.

Kim M, Alapan Y, Adhikari A, Little JA, Gurkan UA. Hypoxia-enhanced adhesion of red blood cells in microscale flow. Microcirculation. 2017 Jul;24(5). doi: 10.1111/micc.12374. PubMed PMID: 28387057; PubMed Central PMCID: PMC5679205.

View Publications

Jane Little, MD