Hemodialysis patient care and research; advanced kidney disease patient care; patient-centered outcomes research; epidemiology
Education and Experience
BS Cum Laude: Duke University, 1999
MD: University of North Carolina Chapel Hill, 2006
Resident: Oregon Health & Science University, 2006-2009
Hospitalist: Kaiser Permanente 2009-2010
Nephrology Fellow: Brigham and Women’s Hospital/ Massachusetts General Hospital Joint Program, 2010-2012
MPH: Harvard School of Public Health, 2013
Clinical Faculty: Brigham and Women’s Hospital, 2013-2014
Assistant Professor of Medicine: University of North Carolina, 2014-2019
Associate Professor of Medicine: University of North Carolina, 2019-present
Internal Medicine and Nephrology
Research and Clinical Interests
Dr. Flythe’s research interests include identifying and understanding modifiable mortality determinants among maintenance dialysis patients and developing innovative treatment strategies to reduce these risks. She is particularly interested in hemodialysis procedural risk factors. The majority of her work focuses on dialysis hemodynamics, fluid management, and blood pressure patterns among maintenance hemodialysis patients. She also incorporates patient-centered outcomes and patient preferences into her work to ensure that patient-stated priorities drive outcomes research.
At UNC, Dr. Flythe is involved in the management of acute and chronic kidney disease patients with a focus on hemodialysis patients at the UNC Hospital and Kidney Center and its associated outpatient dialysis facilities.
Flythe JE, Powell JD, Poulton CJ, Westreich KD, Handler L, Reeve BB, Carey TS. Patient-Reported Outcome Instruments for Physical Symptoms Among Patients Receiving Maintenance Dialysis: A Systematic Review. Am J Kidney Dis. 2015 Jul 23. Epub ahead of press.
Flythe JE, Kshirsagar AV, Falk RJ, Brunelli SM. Associations of Post-hemodialysis Weights above and below Target Weight with All-Cause and Cardiovascular Mortality. Clin J Am Soc Nephrol. 2015;10(5):808-16.
Flythe JE, Brookhart MA. Fluid management: the challenge of defining standards of care. Clin J Am Soc Nephrol. 2014;9(12):2033-5.
Flythe JE, Xue H, Lynch KE, Curhan GC, Brunelli SM. Association of mortality risk with various definitions of intradialytic hypotension. J Am Soc Nephrol. 2015;(3):724-34.
Flythe JE, Mangione TW, Brunelli SM, Curhan GC. Patient-stated preferences regarding volume-related risk mitigation strategies for hemodialysis. Clin J Am Soc Nephrol. 2014;9(8):1418-25.
Flythe JE, Curhan GC, Brunelli SM. Disentangling the ultrafiltration rate–mortality association: the respective roles of session length and weight gain. Clin J Am Soc Nephrol 2013;8(7):1151-61.
Flythe JE, Inrig JK, Shafi T, Chang TI, Cape K, Dinesh K, Kunaparaju S, Brunelli SM. Association of intradialytic blood pressure variability with increased all-cause and cardiovascular mortality in patients treated with hemodialysis. Am J Kidney Dis 2013;61(6):966-74.
Flythe JE, Curhan GC, Brunelli SM. Shorter length dialysis sessions are associated with increased mortality independent of body weight. Kidney Int 2013;83(1):104-13.
Flythe JE, Kunaparju S, Dinesh K, Cape K, Feldman HI, Brunelli SM. Factors associated with intradialytic blood pressure variability. Am J Kidney Dis 2012;59(3):409-418.
Flythe JE, Brunelli SM. The risks of high ultrafiltration rate in chronic hemodialysis: implications for patient care. Semin Dial 2011;24(3):259-265.
Flythe JE, Kimmel SE, Brunelli SM. Rapid fluid removal during dialysis is associated with cardiovascular morbidity and mortality. Kidney Int 2011; 79(2):250-257.