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John P. Vavalle, MD, MHS, FACC

Assistant Professor of Medicine
Medical Director, UNC Structural Heart Disease Program
Associate Program Director, Cardiovascular Disease Fellowship Program & Interventional Cardiovascular Fellowship Program

Specialty Areas

Transcatheter Aortic Valve Replacement (TAVR); MitraClip; Percutaneous atrial and ventricular septal defect closure; Percutaneous coronary interventions; Alcohol septal ablation; Aortic and mitral balloon valvuloplasty.

Education and Experience

MD: University of North Carolina, 2004; Intern and Resident: University of North Carolina, Internal Medicine, 2004-2007; Chief Resident: University of North Carolina, Internal Medicine, 2007-2008; Fellow: Duke University, Cardiovascular Disease, 2008-2012; MHS: Duke University, Health Sciences and Clinical Research with additional coursework focused on Research Training & Methods, 2010-2012; Fellow: Duke University, Interventional Cardiology, 2012-2013; Fellow: Duke University, Transcatheter Valvular and Structural Interventions, 2013-2014; Board Certified Internal Medicine, 2007; Board Certified Internal Medicine/Cardiovascular Disease, 2011; Board Certified Internal Medicine/Interventional Cardiology, 2014.

Clinical Interests

Dr. Vavalle’s main areas of interest is in percutaneous structural and valvular heart disease interventions, as well as coronary interventions. As Medical Director of the Structural Heart Disease Program at UNC, he successfully performed the first TAVR procedure at UNC in 2014. Dr. Vavalle also leads the UNC Heart Valve Clinic where a multi-disciplinary team of cardiac surgeons, cardiologists, and advanced practice providers evaluate patients with valvular heart disease to determine the best treatment options available.

With the rapid evolution in the fields of interventional cardiology and cardiac surgery, Dr. Vavalle focuses on increasing partnerships between the two specialties to create a seamless program where cardiologists and cardiac surgeons work together to perform hybrid and minimally invasive cardiac procedures.

Dr. Vavalle also offers procedural expertise in complex coronary interventions, transcatheter closure of paravalvular leaks, repair of congenital cardiac defects, and closure of coronary fistulas. In addition to the UNC Heart Valve Clinic located at the UNC Medical Center, Dr. Vavalle sees patients in a general cardiology clinic at UNC Heart & Vascular at Meadowmont.

Selected Bibliography

In-Hospital Outcomes After Transcatheter Versus Surgical Aortic Valve Replacement in Octogenarians. Sheng SP, Strassle PD, Arora S, Kolte D, Ramm CJ, Sitammagari K, Guha A, Paladugu MB, Cavender MA and Vavalle JP. J Am Heart Assoc. 2019;8:e011206.

The Prevalence and Impact of Atrial Fibrillation on 1-Year Outcomes in Patients Undergoing Transcatheter Mitral Valve Repair: Results From the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry. Arora S, Vemulapalli S, Stebbins A, Ramm CJ, Kosinski AS, Sorajja P, Piccini JP, Cavender MA and Vavalle JP. JACC Cardiovasc Interv. 2019;12:569-578.

Relation of an Echocardiographic-Based Cardiac Calcium Score to Mitral Stenosis Severity and Coronary Artery Disease in Patients with Severe Aortic Stenosis. Sheng SP, Howell LA, Caughey MC, Yeung M and Vavalle JP.Am J Cardiol. 2018;121:249-255.

In-hospital outcomes after switching from a bivalirudin-first strategy to an unfractionated heparin-first strategy for percutaneous coronary interventions. Jaswaney RV, Caughey MC, End C, Sudar P, Yeung M, Kaul P, Rossi JS, Stouffer GA and Vavalle JP. Cardiovasc Diagn Ther. 2018;8:137-145.

Length of Stay and Discharge Disposition After Transcatheter Versus Surgical Aortic Valve Replacement in the United States. Arora S, Strassle PD, Kolte D, Ramm CJ, Falk K, Jack G, Caranasos TG, Cavender MA, Rossi JS and Vavalle JP. Circ Cardiovasc Interv. 2018;11:e006929.

A heart team and multi-modality imaging approach to percutaneous closure of a post-myocardial infarction ventricular septal defect. Iyer S, Bauer T, Yeung M, Ramm C, Kiser AC, Caranasos TG, Vavalle JP. Cardiovasc Diagn Ther. 2016 Apr;6(2):180-4. doi: 10.21037/cdt.2015.10.04.

Renal failure in patients with ST-segment elevation acute myocardial infarction treated with primary percutaneous coronary intervention: Predictors, clinical and angiographic features, and outcomes. Vavalle JP, van Diepen S, Clare RM, Hochman JS, Weaver WD, Mehta RH, Pieper KS, Patel MR, Patel UD, Armstrong PW, Granger CB, Lopes RD. Am Heart J. 2016 Mar;173:57-66. doi: 10.1016/j.ahj.2015.12.001. Epub 2015 Dec 11.

Effect of the Presence and Type of Angina on Cardiovascular Events in Patients Without Known Coronary Artery Disease Referred for Elective Coronary Angiography. John P. Vavalle, MD, MHS1; Lan Shen, MD, MHS2; Samuel Broderick, MS3; Linda K. Shaw, MS3; Pamela S. Douglas, MD3. JAMA Cardiol. 2016 May 1;1(2):232-4. doi: 10.1001/jamacardio.2016.0076.

Aortic valve surgery and survival in patients with moderate or severe aortic stenosis and left ventricular dysfunction. Samad Z, Vora AN, Dunning A, Schulte PJ, Shaw LK, Al-Enezi F, Ersboll M, McGarrah RW 3rd,Vavalle JP, Shah SH, Kisslo J, Glower D, Harrison JK, Velazquez EJ. Eur Heart J. 2016 Jan 18. pii: ehv701.

Factor VIIa for Annulus Rupture After Transcatheter Aortic Valve Replacement. Keenan JE, Vavalle JP, Ganapathi AM, Wang H, Harrison JK, Wang A, Hughes GC. Ann Thorac Surg. 2015 Jul;100(1):313-5. doi: 10.1016/j.athoracsur.2014.09.063.