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Herman and Louise Smith Distinguished Professor of Medicine
Chief, Division of Infectious Diseases
Director, Clinical Core, UNC Center for AIDS Research
Associate Director, General Clinical Research Unit
Adjunct Professor of Epidemiology, Gillings School of Global Public Health


M.D., Harvard Medical School, 1984

Board Certifications

National Board of Medical Examiners, 1984
American Board of Internal Medicine, 1987
American Board of Internal Medicine, Infectious Diseases, 1991

Clinical Interests

HIV care, antiretroviral therapy including advanced patients, HIV resistance, primary HIV infection

Research Interests

My research interests are focused primarily on the study of HIV/AIDS. Current research interests include clinical development of combination antiretroviral therapy including novel agents, HIV resistance to antiretroviral therapy and the use of resistance testing and pharmacokinetic assessment to construct success therapy in treatment experienced patients. Additional interests include the study of primary (acute) HIV infection, HIV transmission and HIV penetration and antiretroviral penetration into tissue compartments such as genital track and central nervous system. Newer areas of investigation include development of a Clinical/Research HIV relational database in collaboration with SAS, development of a therapeutic HIV vaccine in conjunction with Robert Johnston Ph.D., and the study of antiretroviral combination therapy in the developing world both for treatment and prevention of transmission in conjunction with Myron S. Cohen, Charles van der Horst and colleagues.


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