Cardiology, mitochondria, nuclear receptors.
Education and Experience
BS, Kyungpook National University, 1997; MS, Kyungpook National University 2001; Ph. D. Kyungpook National University 2003; Visiting fellow, National Institute of Environmental Health Sciences, 2003 – 2008; Post-Doctoral Fellow, Department of Medicine 2015 – 2019; Assistant Professor 2019 – present.
The constant contraction and relaxation of cardiac muscle cells requires a tremendous amount of energy that is generated from the electron transport chains in mitochondria. Dysfunction of cardiomyocyte mitochondria leads to heart failure. Mitophagy is a key biological process for the maintenance of healthy cardiac mitochondria. Our group demonstrated a protective role of RAR-related nuclear receptor (RORa) against angiotensin II-mediated cardiac hypertrophy. Recently, we discovered that RORa plays a crucial role in maintenance of mitochondrial quality and in regulation of cardiac inflammation. My ongoing research interest is to reveal the role of RORa in preserving cardiac mitochondrial function.
Willis, MS, Parry TL, Brown DI, Mota RI, Huang W, Beak JY, Sola M, Zhou C, Hicks ST, Caughey MC, D’Agostino RB Jr, Jordan J, Hundley WG, Jensen BC. Doxorubicin Exposure causes subacute cardiac atrophy dependent on the striated muscle-specific ubiquitin ligase MuRF1. Circ Heart Fail. 2019 Mar; 12(3):e005234.
Beak, JY, Kang HS, Huang W, Myers PH, Bowles DE, Jetten AM, Jensen BC. The nuclear receptor RORα protects against angiotensin II-induced cardiac hypertrophy and heart failure. Am J Physiol Heart Circ Physiol. 2019 Jan;316(1):H186-H200.
Shorter, JR, Huang W, Beak JY, Hua K, Gatti DM, de Villena FP, Pomp D, Jensen BC. Quantitative trait mapping in diversity outbred mice identifies two genomic regions associated with heart size. Mamm Genome. 2018 Feb;29(1-2):80-89.
Stuhlmiller, TJ, Zawistowski JS, Chen X, Sciaky N, Angus SP, Hicks ST, Parry TL, Huang W, Beak JY, Willis MS, Johnson GL, Jensen BC. Kinome and transcriptome profiling reveal broad and distinct activities of Erlotinib, Sunitinib, and Sorafenib in the mouse heart and suggest cardiotoxicity from combined signal transducer and activator of transcription and epidermal growth factor receptor inhibition. J Am Heart Assoc. 2017 Oct;6(10):e006635.
Jensen, BC, Parry TL, Huang W, Beak JY, Ilaiwy A, Bain JR, Newgard CB, Muehlbauer MJ, Patterson C, Johnson GL, Willis MS. Effects of the kinase inhibitor sorafenib on heart, muscle, liver and plasma metabolism in vivo using non-targeted metabolomics analysis. Br J Pharmacol. 2017 Dec;174(24):4797-4811
Beak, J, Huang W, Parker JS, Hicks ST, Patterson C, Simpson PC, Ma A, Jin J, Jensen BC. An oral selective alpha-1A adrenergic receptor agonist prevents doxorubicin cardiotoxicity. JACC Basic Transl Sci. 2017 Feb; 2(1):39-53.
Kang, HS, Okamoto K, Takeda Y, Beak JY, Gerrish K, Bortner CD, DeGraff LM, Wada T, Xie W, Jetten, AM. Transcriptional profiling reveals a role for RORalpha in regulating gene expression in obesity-associated inflammation and hepatic steatosis. Physiol Genomics. 2011 Jul;43(13):818-28.
Kang, HS, Kim YS, ZeRuth G, Beak JY, Gerrish K, Kilic G, Sosa-Pineda B, Jensen J, Pierreux CE, Lemaigre FP, Foley J, Jetten AM. (2009) Transcription factor Glis3, a novel critical player in the regulation of pancreatic beta-cell development and insulin gene expression. Mol Cell Biol. 2009 Dec;29(24):6366-79.
Kang, HS, Beak JY*, Kim YS, Herbert R, Jetten AM. (2009) Glis3 is associated with primary cilia and Wwtr1/TAZ and implicated in polycystic kidney disease. Mol Cell Biol. 2009 Mar;29(10):2556-69. (*: co-first author)
Beak, JY, Kang HS, Kim YS, Jetten AM. Functional analysis of the zinc finger and activation domains of Glis3 and mutant Glis3(NDH1). Nucleic Acids Res. 2008 Mar;36(5):1690-702.
Beak, JY, Kang HS, Kim YS, Jetten AM. Krüppel-like zinc finger protein Glis3 promotes osteoblast differentiation by regulating FGF18 expression. J Bone Miner Res. 2007 Aug;22(8):1234-44.
Kang, HS, Beak JY, Kim YS, Petrovich RM, Collins JB, Grissom SF, Jetten AM. NABP1, a novel RORgamma-regulated gene encoding a single-stranded nucleic-acid-binding protein. Physiol. Genomics 2007 Oct;31(2):89-99.
Kang, HS, Beak JY, Kim YS, Petrovich RM, Collins JB, Grissom SF, Jetten AM. (2006) NABP1, a novel RORgamma-regulated gene encoding a single-stranded nucleic-acid-binding protein. Biochem J. 2006 Jul;397(1):89-99.