Klara Klein, MD, PhD

Fellow, Division of Endocrinology and Metabolism
PGY-3 Trainee, Physician Scientist Training Program

Education

Undergraduate: Stanford University
MD/PhD: University of North Carolina School of Medicine

Hometown

Atlanta, GA

Career interests

Klara is a member of the PSTP program, planning to fast-track into Endocrinology and study diabetes and obesity.

Klara was born and grew up in Atlanta before traveling cross-country to do her undergraduate work at Stanford University, where she pursued research in synthetic organic chemistry. She then joined UNC’s MD-PhD program and completing her PhD in Cell and Molecular Physiology under the mentorship of Dr. Kathleen Caron. Her research focused on the role of a small peptide hormone, Adrenomedullin, in the development of the lymphatic vascular system, an understudied vessel network increasingly recognized to play critical roles in normal physiology and disease states. Using in vivo and in vitro techniques, Klara helped identify a new role for G-protein coupled receptors, and particularly decoy receptors, in lymphatic vascular development and function. Klara has entered Research Pathway training in Internal Medicine and Endocrinology with plans to pursue a career in translational medicine, focusing on multi-disciplinary approaches to diabetes and obesity care. With her background in bench research, Klara hopes to bridge gaps between between basic and clinical researchers in order to address the ongoing epidemics of diabetes and obesity.

Publications

Klein, K., Asaad S, Econs M, Rubin, JE. Severe FGF23-based hypophosphataemic osteomalacia due to ferric carboxymaltose administration. BMJ Case Rep. 2018 Jan. PMID: 29298794

Klein, K.R., Matson, B.C., Caron, K.C. The expanding repertoire of receptor activity modifying protein (RAMP) function. Critical Reviews In Biochemistry & Molecular Biology. 2016 Jan-Feb;51(1):65-71. PMID: 26740457

Klein, K.R. and Caron, K.C. Adrenomedullin and Lymphangiogenesis: From development to disease. Cell. Mol. Life Sci. 2015 Aug; 72(16)3115-31126. PMID 25953627.

Klein, K.R., Karpinich, N.O., Espenschied, S.T., Willcockson, H.H., Dunworth, W.P., Hoopes, S.L., Kushner, E.J., Bautch, V.L., Caron, K.M. Decoy receptor CXCR7 modulates adrenomedullin-mediated cardiac and lymphatic vascular development. Dev. Cell. 2014 Sep 8;30(5)528-40. PMID: 25203207

Wetzel-Strong, S.E., Li, M., Klein, K.R., Nishikimi, T., and Caron, K.M. Epicardial-derived adrenomedullin drives cardiac hyperplasia during embryogenesis. Dev. Dyn. 2013 Oct 3; 243: 243-256. PMID: 24123312

Billedeau R.J., Klein K.R., Kaplan D, Lou, Y. A New Pyrrole Synthesis via Silver(I)-Catalyzed Cycloaddition of Vinylogous Diazoester and Nitrile. Org Lett. 2013 Mar;(15)7:1421-3. PMID: 23477583

Muller R.E., Klein K.R., Hutsell S.Q., Siderovski D.P., Kimple A.J. A homogenous method to Measure nucleotide exchange by a-subunits of heterotrimeric G-proteins using Fluorescence polarization. Assay Drug Dev Technol. 2010 Oct;8(5):621-4. PMID:20662737