Metabolic bone disease, osteoporosis, lipodystrophies, and general endocrinology.
Education and Experience
Biomedical Research Summer Intern: National Institutes of Health, 1993-1994; BS in Biology with Honors: UNC-CH,1993-1997; Pre-doctoral Intramural Research Training Award: National Institutes of Health, 1997-1998; MD: UNC-CH, 1998-2002; Research Associate: University of Bern, Switzerland, Department of Clinical Research, 2002-2004; Resident Physician in Kreisspital Muri, Switzerland, 2/2004-06/2004; Residency in Internal Medicine: UNC-CH, 2004-2007; Fellowship in Endocrinology and Metabolism: University of North Carolina, 2007-2010; Endocrinology Fellowship Research Training Grant Recipient: UNC-CH, 2007-2010; BIRCWH Scholar: UNC-CH, 2010-2012; Clinical Instructor: University of North Carolina, 2010-2012; K08 Awardee: UNC-CH, 2012-present; Assistant Professor of Medicine: University of North Carolina, 2012-present.
Clinical and Research Interests
Dr. Styner’s practice consists of consultation and ongoing care for patients with endocrine disorders and diabetes, with a focus on metabolic bone disease and osteoporosis.
Dr. Styner’s research is focused on bone health and metabolic health—work that directly applies to patient care in her practice. In the laboratory, she studies how exercise regulates the poorly understood fat in the bone, also known as marrow fat. These studies will inform future treatments designed to improve skeletal and metabolic health.
Styner M, Pagnotti GM, McGrath C, Wu X, Sen B, Uzer G, Xie Z, Zong X, Styner MA, Rubin CT, Rubin J. Exercise Decreases Marrow Adipose Tissue Through ß-Oxidation in Obese Running Mice. J Bone Miner Res. 2017 Aug;32(8):1692-1702. PubMed PMID: 28436105; PubMed Central PMCID: PMC5550355.
Styner M, Pagnotti GM, Galior K, Wu X, Thompson WR, Uzer G, Sen B, Xie Z, Horowitz MC, Styner MA, Rubin C, Rubin J. Exercise Regulation of Marrow Fat in the Setting of PPARγ Agonist Treatment in Female C57BL/6 Mice. Endocrinology. 2015 Aug;156(8):2753-61. PubMed PMID: 26052898; PubMed Central PMCID: PMC4511140.
Styner M, Thompson WR, Galior K, Uzer G, Wu X, Kadari S, Case N, Xie Z, Sen B, Romaine A, Pagnotti GM, Rubin CT, Styner MA, Horowitz MC, Rubin J. Bone marrow fat accumulation accelerated by high fat diet is suppressed by exercise. Bone. 2014 Jul;64:39-46. PubMed PMID: 24709686; PubMed Central PMCID: PMC4041820.
Styner M, Meyer MB, Galior K, Case N, Xie Z, Sen B, Thompson WR, Pike JW, Rubin J. Mechanical strain downregulates C/EBPβ in MSC and decreases endoplasmic reticulum stress. PLoS One. 2012;7(12):e51613. PubMed PMID: 23251594; PubMed Central PMCID: PMC3520924.