Specialty Areas (clinical or research areas of expertise): Critical Care Medicine, Acute Respiratory Distress Syndrome, Sarcoidosis, and Pulmonary Medicine
Chronology: BS Summa Cum Laude: Texas A&M University, 1999; MD/PhD: University of Texas Southwestern Medical School, 2007; Resident: Johns Hopkins Hospital, 2007-2010; Pulmonary and Critical Care Fellow: Johns Hopkins Hospital, 2010-2014; Clinical Instructor: University of North Carolina, 2014-2017; Assistant Professor , Tenure Track, 2017 -present
Description of research and/or clinical interests:
Dr. Mock’s research interests include studying the immunological processes in lung repair and resolution. This includes Acute Respiratory Distress Syndrome (ARDS) which is characterized by hypoxemia, capillary leakage, edema, and cell damage. Little information is known about the resolution phase of ARDS; however, Regulatory T cells (Tregs) have been demonstrated to be important determinant in lung injury resolution in animal models. Furthermore, Tregs have been detected in the bronchoalveolar fluid of patients with ARDS—suggesting that they may be important in the human immunological response to ARDS. In acute or chronic lung injury the failure to regenerate the lung epithelium plays a role in such processes as acute lung injury, pneumonia, pulmonary fibrosis, cancer, COPD, and aging. Recently, there has been considerable interest in investigating the cells types involved in repair along with the determinants which regulate these processes. The focus of our group is to further examine lymphocyte and epithelium interactions during resolution of lung injury. Recently our laboratory has demonstrated that Tregs from experimental lung injury models express a growth factor which enhances lung epithelial proliferation supporting the expanding role of Tregs not only in immune suppression and regulation but also in tissue repair. These studies enhance our understanding of lung repair with the hope of identifying novel mechanisms that may lead to potential treatment options in patients with ARDS and inflammatory lung diseases.
Dr. Mock’s clinical interests include critical care medicine and inflammatory lung diseases such as sarcoidosis.
Selected Bibliography (reverse chronological order):
Dial DF, Tune MK, Doerschuk CM, and Mock JR. “Foxp3+ Regulatory T Cell Expression of Keratinocyte Growth Factor Enhances Lung Epithelial Proliferation.” Online March 15, 2017 Am. J. Respir. Cell Mol. Biol. PMID: 28296468
Mock JR, Singer BD, and D’Alessio FR. “Flow Cytometric Evaluation of Acute Lung Injury and Repair.” Acute Lung Injury and Repair: Scientific Fundamentals and Methods. Editors: Schnapp LM and Feghali-Bostwick C Springer 2017. pages 85-106.
Mock JR, Kolb TK, Illei PB, Yang SC, Lederman HM, and Merlo CA. “Bronchus Associated Lymphoid Tissue in Kabuki Syndrome with Associated Hyper-IgM Syndrome/Common Variable Immunodeficiency” Am J Respir Crit Care Med. 2016 Aug 15; 194(4):514-515. PMID: 27275756
Singer BD, Mock JR, D’Alessio FR, Aggarwal NR. Mandke P, Johnston L, Damarla M. “Flow-cytometric method for simultaneous analysis of mouse lung epithelial, endothelial, and hematopoietic lineage cells” Am J Physiol Lung Cell Mol Physiol. 2016 May 1;310(9) PMID: 26944088
Kolb TM, Peabody J, Baddoura P, Fallica J, Mock JR, Singer BD, D’Alessio FR, Damarla M, Damico R. “Right ventricular angiogenesis is an early adaptive response to chronic hypoxia-induced pulmonary hypertension” Microcirulation 2015 Sep 9 PMID: 26352923
Limjunyawong N, Mock JR, and Mitzner W. “Instillation and Fixation Methods Useful in Mouse Lung Cancer Research” J. Vis. Exp. (102), e52964, doi:10.3791/52964 (2015).
Singer BD, Mock JR, Garibaldi BT, Aggarwal NR, Sidhaye VK, Florez MA, Chau E, Gibbs KW, Mandke P, Tripathi A, Yegnasubramanian S, King LS, D’Alessio FR. “Regulatory T cell DNA methyltransferase inhibition accelerates resolution of lung inflammation.” Am J Respir Cell Mol Biol. 2015: May; 52(5):641-52 PMID: 25295995
Files DC, Liu C, Pereyra A, Wang Z, Aggarwal NR, D’Alessio FR, Garibaldi BT, Mock JR, Singer BD, Feng X, Lee AL, Philpott S, Lussier S, Purcell L, Chou J, Seeds M, King LS, Morris PE, Delbono O. “Therapeutic Exercise Attenuates Neutrophilic Lung Injury and Skeletal Muscle Wasting.” Sci Transl Med. 2015 Mar 11;7(278):278-32 PMID: 25761888
Mock JR, Garibaldi BT, Aggarwal NR, Singer BD, Chau E, Rabold R, Files DC, Jenkins J, Sidhaye V, Wagner E, D’Alessio FR, and King LS. “CD4+ Foxp3+ Regulatory T Cells Promote Epithelial Proliferation.” Mucosal Immunol. 2014 Nov;7(6):1440-51 PMID: 24850425
Yao Q, Shin MK, Jun JC, Hernandez KL, Aggarwal NR, Mock JR, Gay J, Drager LF, Polotsky VY. “The Effect of Chronic Intermittent Hypoxia on Triglyceride Uptake in Different Tissues.” J Lipid Res. 2013 Apr;54(4):1058-65. PMID: 23386706
Garibalid BT, D’Alessio FR, Mock JR, Files DC, Chau E, Yoshiki E, Drummon MB, Aggarwal NR, Sidhaye V, King LS. Regulatory T cells Reduce Acute Lung Injury Fibroproliferation By Decreasing Fibrocyte Recruitment. Am. J. Respir. Cell Mol. Biol. 2013 Jan;48(1):35-43. PMID: 23002097
D’Alessio FR, Tsushima K, Aggarwal NR, Mock JR, Eto Y, Garibaldi BT, Files DC, Avalos CR, Rodriguez JV, Waickman AT, Reddy SR, Pearse, DB, Sidhaye, VK, Hassoun PM, Crow MT, King LS. Resolution of Experimental Lung Injury by Monocyte-Derived Inducible Nitric Oxide Synthase (iNOS). J Immunol. 2012 Sept 1; 189(5):2234-45 PMID: 22844117
Files DC, D’Alessio FR, Johnston L, Kesari P, Aggarwal NR, Garibaldi BT, Mock JR, Simmers J, DeGorordo A, Murdoch J, Willis MS, Patterson C, Tanskersley CG, Cohn RD, King LS, Crow MT. A Critical Role for Muscle Ring Finger-1 in Acute Lung Injury-associated Skeletal Muscle Wasting. Am. J. Respir. Crit. Care Med. 2012; 185; 825-834. PMID: 22312013
Labandeira-Rey M, Mock JR, Hansen EJ. “Regulation of expression of the Haemophilus ducreyi LspB and LspA2 proteins by CpxR.” Infect Immun. 2009; 77(8): 3402-11. PMID: 19451237
Deng K, Mock JR, Greenberg S, van Oers NS, Hansen EJ. “Haemophilus ducreyi LspA proteins are tyrosine phosphorylated by macrophage-encoded protein tyrosine kinases.” Infect Immun. 2008; 76(10): 4692-702. PMID: 18678665
Mock JM, Vakevainen M, Deng K, Latimer JL, Young JA, van Oers N, Greenberg S, Hansen EJ. “Haemophilus ducreyi targets Src family protein tyrosine kinases to inhibit phagocytic signaling.” Infect Immun. 2005; 73(12):7808-7816. PMID: 16299270
Ward CK, Mock JR, Hansen EJ. “The LspB protein is an outer membrane protein involved in the export of the LspA1 and LspA2 proteins of Haemophilus ducreyi.” Infect Immun. 2004; 72(4): 1874-1884. PMID: 15039306
Spinola SM, Fortney KR, Katz BP, Latimer JL, Mock JR, Vakevainen M, Hansen EJ. “Haemophilus ducreyi requires an intact flp gene cluster for virulence in humans.” Infect Immun. 2003; 71(12): 7178-82. PMID: 14638812
Ward CK, Latimer JL, Nika J, Vakevainen M, Mock JR, Deng K, Blick RJ, Hansen EJ. “Mutations in the lspA1 and lspA2 genes of Haemophilus ducreyi affect the virulence of this pathogen in an animal model system.” Infect Immun. 2003; 71(5):2478-86. PMID: 12704119