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Nicole M. Orzechowski, DO, RhMSUS

Associate Professor of Medicine; Medical Director, UNC Rheumatology Clinic

Specialty Areas: general rheumatology, scleroderma, musculoskeletal ultrasound, medical education

Chronology: BS: University of Scranton, 1997; DO: Philadelphia College of Osteopathic Medicine, 2002; Osteopathic Internship: Community General Osteopathic Hospital, 2003; Internal Medicine Resident: Mayo Clinic Rochester, 2003-2006; Rheumatology Fellow: Mayo Clinic Rochester; 2006-2008; Assistant Professor of Medicine: Geisel School of Medicine at Dartmouth, 2008-2020; Staff Physician, Section of Rheumatology, Dartmouth-Hitchcock, 2008-2020; Rheumatology Fellowship Program Director: Dartmouth Hitchcock, 2014-2020; Section Chief: Dartmouth Hitchcock, 2014-2019; Associate Professor of Medicine: University of North Carolina, 2020-present; Medical Director, UNC Rheumatology Clinic, 2021-present.

Description of Research and/or clinical interests: Dr. Orzechowski’s clinical interests are in the evaluation and management of patients with inflammatory arthritis and scleroderma, and in the use of musculoskeletal ultrasound for diagnosis and response to treatment in rheumatologic conditions. She strives to provide exceptional individualized care to each of her patients.  Her academic interests are in medical education where she has mentored medical students, residents and Rheumatology fellows, and is involved in educational committees at the American College of Rheumatology. She has experience in enhancing care for Rheumatology patients through novel care delivery models.

Selected Bibliography:

Profibrotic Activation of Human Macrophages in Systemic Sclerosis. Bhandari R, Ball MS, Martyanov V, Popovich D, Schaafsma E, Han S, ElTanbouly M, Orzechowski NM, Carns M, Arroyo E, Aren K, Hinchcliff M, Whitfield ML, Pioli PA. Arthritis Rheumatol. 2020 Jul;72(7):1160-1169. doi: 10.1002/art.41243. Epub 2020 May 31. PMID: 32134204

Microbiome dysbiosis is associated with disease duration and increased inflammatory gene expression in systemic sclerosis skin. Johnson ME, Franks JM, Cai G, Mehta BK, Wood TA, Archambault K, Pioli PA, Simms RW, Orzechowski N, Arron S, Whitfield ML. Arthritis Res Ther. 2019 Feb 6;21(1):49. doi: 10.1186/s13075-019-1816-z. PMID: 30728065

Prevalence rates of arthritis among US older adults with varying degrees of depression: Findings from the 2011 to 2014 National Health and Nutrition Examination Survey. Brooks JM, Titus AJ, Polenick CA, Orzechowski NM, Reid MC, MacKenzie TA, Bartels SJ, Batsis JA. Int J Geriatr Psychiatry. 2018 Dec;33(12):1671-1679. doi: 10.1002/gps.4971. Epub 2018 Sep 19. PMID: 30229563

Depression and Handgrip Strength Among U.S. Adults Aged 60 Years and Older from NHANES 2011-2014. Brooks JM, Titus AJ, Bruce ML, Orzechowski NM, Mackenzie TA, Bartels SJ, Batsis JA. J Nutr Health Aging. 2018;22(8):938-943. doi: 10.1007/s12603-018-1041-5. PMID: 30272097

Antisense Long Non-Coding RNAs Are Deregulated in Skin Tissue of Patients with Systemic Sclerosis. Messemaker TC, Chadli L, Cai G, Goelela VS, Boonstra M, Dorjée AL, Andersen SN, Mikkers HMM, van ‘t Hof P, Mei H, Distler O, Draisma HHM, Johnson ME, Orzechowski NM, Simms RW, Toes REM, Aarbiou J, Huizinga TW, Whitfield ML, DeGroot J, de Vries-Bouwstra J, Kurreeman F. J Invest Dermatol. 2018 Apr;138(4):826-835. doi: 10.1016/j.jid.2017.09.053. Epub 2017 Nov 24. PMID: 29179949Top of Form

Pain intensity, depressive symptoms, and functional limitations among older adults with serious mental illness. Brooks JM, Polenick CA, Bryson W, Naslund JA, Renn BN, Orzechowski NM, Almeida M, Bartels SJ. Aging Ment Health. 2019 Apr;23(4):470-474. doi: 10.1080/13607863.2017.1423025. Epub 2018 Jan 22. PMID: 29356566


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