Nigel Mackman, PhD, FAHA

John Parker Distinguished Professor of Medicine
Co-Director,Thrombosis and Hemostasis Program

Specialty Areas

The role of tissue factor (TF), coagulation proteases, protease activated receptors (PARs) and microvesicles (MVs) in ischemia-reperfusion (I/R) injury, cancer, sickle cell disease, obesity, viral infection, atherosclerosis and liver injury.

Education and Experience

BSc: University of Leicester, 1982; PhD (Genetics): University of Leicester, 1985; Postdoctoral Fellow: University of Leicester, 1985-1987; Postdoctoral Fellow: Scripps Clinic and Research Foundation, 1987-1989; Assistant Professor of Medicine (Department of Immunology): Scripps Clinic and Research Foundation, 1989-1995; Associate Professor of Medicine (Department of Immunology): Scripps Clinic and Research Foundation, 1995-2007; John Parker Distinguished Professor of Medicine: University of North Carolina, 2007-present;  Co-Director: Thrombosis and Hemostasis Program, University of North Carolina, 2007-present; Associate Director: UNC McAllister Heart Institute, 2009-2011; Director: UNC McAllister Heart Institute, 2011-2017.

Research Interests

Dr. Mackman began his scientific career studying the role of Escherichia coli hemolysin toxin in bacterial pathogenesis. He received a PhD from the University of Leicester. In 1987 he moved to The Scripps Research Institute in California as a postdoctoral fellow to study blood coagulation and rose to the rank of Associate Professor with tenure. In 2007, Dr. Mackman moved to the University of North Carolina at Chapel Hill to become the John C. Parker Distinguished Professor in Medicine. His research has focused on the roles of tissue factor, coagulation proteases, protease activated receptors, extracellular vesicles, thrombosis, inflammation, ischemia-reperfusion injury, cancer, sickle cell disease, obesity, viral infection and atherosclerosis.

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