Peadar Noone, MD FCCP FRCPI DCH MRCGP

Professor of Medicine, Division of Pulmonary Diseases and Critical Care Medicine
Medical Director, UNC Center for Bronchiectasis Care

Specialty Areas: General pulmonary medicine, cystic fibrosis, non-CF bronchiectasis, non-tuberculous mycobacterial infection of the lung, Bedside clinical teaching, curriculum, design and reform, medical student teaching and mentorship. Novel therapies for, and genetics of CF and non-CF bronchiectasis.

Chronology: MB BCh BAO National University of Ireland Galway 1983; MRCPI, Royal College of Physicians of Ireland 1985; DCH, RCPI 1991; MRCGP (UK) 1992. MD (Doctoral Thesis) NUI Galway 1997. FRCPI 2007. Best Doctors in America 2008-date. AOA UNC 2015. Resident/Senior Resident University Hospital Galway, University Hospital, St Vincent’s Dublin, and Trinity College / St James’ Hospital Dublin 1983-9. Fellowship Tufts University Boston MA 1989-90 and University of North Carolina 1992-5. Instructor, Pulmonary Division, UNC 1995-7; Assistant Professor of Medicine 1997-2003. Consultant in Respiratory Medicine, Belfast City Hospital Northern Ireland 2003-5. Associate Professor of Medicine, UNC 2005-2014; Professor of Medicine, UNC 2014-date. Medical Director, Lung Transplant Medicine UNC 2005-2014. Clinical skills tutor UNC School of Medicine 2010-date; Capstone Director UNC School of Medicine 2014-date. Co-director TEC Curriculum Individual Phase UNC School of Medicine 2014-date.

Dr. Noone’s scholarly activities include national and international clinical and research expertise in a number of areas, including cystic fibrosis, Primary Ciliary Dyskinesia, non-CF bronchiectasis, non-tuberculous mycobacterial lung infections, lung transplantation, and medical student clinical teaching and examination. I am specifically interested in the molecular basis of, and new therapies directed against, the infectious and molecular aspects of chronic infectious lung diseases. In parallel, I am very enthusiastic as a medical educator to all levels of learners, particularly medical students (physical diagnosis, clinical reasoning, curriculum reform and design).

Bibliography:

Books and Chapters:

1. Primary ciliary dyskinesia. Mary Leigh-Anne Daniels, Sohini Ghosh, and Peadar G Noone (Sr). Current Pulmonology Reports December 2016, Volume 5, Issue 4, pp 191–198

2. Lobo J, Rojas-Balcazar JM, Noone PG (Sr). Recent Advances in Cystic Fibrosis. Clin Chest Medicine 2012 Jun; 33(2): 307-28.

3. LJ Lobo, M Zariwala and PG Noone (Sr). Ciliary Dyskinesias; Primary Ciliary Dyskinesia in Adults. Monograph, Eur Resp Soc (Bronchiectasis) 2011. Chapter 9, pp 130-149

4. Bennett WD, Noone PG, Knowles MR, Boucher RC. Regulation of Mucociliary Clearance by Purinergic Receptors. In Cilia and Mucus: From Development to Respiratory Defense, ed. Salathe M, Marcel Dekker, Inc. NY, 2001, pp 347-360.

5. Noone PG, Knowles MR. Standard Therapy of Cystic Fibrosis Lung Disease. In: Cystic fibrosis in adults. Yankaskas JR, Knowles MR, eds. Lippincott-Raven Publishers, Philadelphia, 1999; pp 145-173.

6. Noone PG, Bresnihan B. Rheumatologic disease in adults with CF. In: Cystic fibrosis in adults. Yankaskas JR, Knowles MR, eds. Lippincott-Raven Publishers, Philadelphia, 1999; pages 439-447.

7. Knowles MR, Noone PG, Bennett WD, Boucher RC. Mucociliary and Cough Clearance: Role of Ion Transport and the P2Y2 Receptor-Mediated System. In: Cilia, Mucus, and Mucociliary Interactions. Baum G, ed. Marcel Dekker, Inc., New York 1998: pp 307-315.

8. Noone PG. MD thesis: Pharmacokinetic and Efficacy Studies of New Treatments for Cystic Fibrosis and Primary Ciliary Dyskinesia 1997, NUIG. (157 pages)

9. Noone PG, Sicilian L. Interstitial Lung Disease. In: Difficult Diagnosis 11. Taylor Ed. WB Saunders, Philadelphia 1992; pp 266-274

Refereed papers/articles:

Pharmacotherapy for non-cystic fibrosis bronchiectasis: results from an NTM Info & Research patient survey and the Bronchiectasis and NTM Research Registry. Henkle E, Aksamit TR, Barker AF, Curtis JR, Daley CL, Daniels ML, DiMango A, Eden E, Fennelly K, Griffith DE, Johnson M, Knowles MR, Leitman A, Leitman P, Malanga E, Metersky ML, Noone PG, O’Donnell AE, Olivier KN, Prieto D, Salathe M, Thomashow B, Tino G, Turino G, Wisclenny S, Winthrop KL. Chest. 2017 May 4. pii: S0012-3692(17)30810-3.

Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium. Bryant JM, Grogono DM, Rodriguez-Rincon D, Everall I, Brown KP, Moreno P, Verma D, Hill E, Drijkoningen J, Gilligan P, Esther CR, Noone PG, Giddings O, Bell SC, Thomson R, Wainwright CE, Coulter C, Pandey S, Wood ME, Stockwell RE, Ramsay KA, Sherrard LJ, Kidd TJ, Jabbour N, Johnson GR, Knibbs LD, Morawska L, Sly PD, Jones A, Bilton D, Laurenson I, Ruddy M, Bourke S, Bowler IC, Chapman SJ, Clayton A, Cullen M, Dempsey O, Denton M, Desai M, Drew RJ, Edenborough F, Evans J, Folb J, Daniels T, Humphrey H, Isalska B, Jensen-Fangel S, Jönsson B, Jones AM, Katzenstein TL, Lillebaek T, MacGregor G, Mayell S, Millar M, Modha D, Nash EF, O’Brien C, O’Brien D, Ohri C, Pao CS, Peckham D, Perrin F, Perry A, Pressler T, Prtak L, Qvist T, Robb A, Rodgers H, Schaffer K, Shafi N, van Ingen J, Walshaw M, Watson D, West N, Whitehouse J, Haworth CS, Harris SR, Ordway D, Parkhill J, Floto RA. Science. 2016 Nov 11;354(6313):751-757. PMID: 27846606

Floto RA, Olivier KN, Saiman L, Daley CL, Herrmann JL, Nick JA, Noone PG, Bilton D, Corris P, Gibson RL, Hempstead SE, Koetz K, Sabadosa KA, Sermet-Gaudelus I, Smyth AR, van Ingen J, Wallace RJ, Winthrop KL, Marshall BC, Haworth CS. US Cystic Fibrosis Foundation and European Cystic Fibrosis Society consensus recommendations for the management of non-tuberculous mycobacteria in individuals with cystic fibrosis: executive summary. Thorax. 2016 Jan;71(1):88-90.

M. Leigh Anne Daniels MD, MPH; Katherine R. Birchard MD; Jared R. Lowe MD; Michael V. Patrone BS; Peadar G. Noone MD, Michael R. Knowles MD. Enlarged dural sac in idiopathic bronchiectasis implicates heritable connective tissue gene variants. Ann Am Thorac Soc. 2016 Oct;13(10):1712-1720.

Leonard J Lobo, Zeynep Tulu, Robert M Aris, and Peadar G Noone. Pan-resistant achromobacter xylosoxidans and stenotrophomonas maltophilia infection in cystic fibrosis does not reduce survival after lung transplantation. Transplantation 2015; Transplantation. 2015 Apr 8. PMID: 25856407. http://www.ncbi.nlm.nih.gov/pubmed/25856407

Mary Leigh Anne Daniels, & Peadar G Noone. Genetics, diagnosis and future treatment strategies for primary ciliary dyskinesia, Expert Opinion on Orphan Drugs 2015, 3:1, 31-44, DOI: 10.1517/21678707.2015.989212. http://dx.doi.org/10.1517/21678707.2015.989212

Jason Lobo, Maimoona A Zariwala and Peadar G Noone. Primary Ciliary Dyskinesia. Semin Respir Crit Care Med. 2015 Apr;36(2):169-79. doi: 10.1055/s-0035-1546748. Epub 2015 Mar 31. PMID: 25826585

Burker EJ, Fingerhut D, Ebeneter D, Giza M, Epsey Weber R, Noone PG, Egan TM. Emergency medical services knowledge about non heart beating donors: Effect of an educational intervention. J Heart Lung Transplant. 2014 Sep 28. pii: S1053-2498(14)01355-2. doi: 10.1016/j.healun.2014.09.020.

JL Lobo, MA Zariwala and PG Noone. Primary Ciliary Dyskinesia. Quarterly Journal of Medicine, London UK. QJM. 2014 Mar 19. PMID: 24652656

Michael R Knowles, Lawrence E Ostrowski, Margaret W Leigh, Patrick R Sears, Stephanie D Davis, Whitney E Wolf, Milan J Hazucha, Johnny L Carson, Kenneth N Olivier, Scott D Sagel, Margaret Rosenfeld, Thomas W Ferkol, Sharon D Dell, Carlos E Milla, Scott H Randell, Weining Yin, Aruna Sannuti, Hilda M Metjian, Peadar G Noone, Peter J Noone, Christina A Olson, Michael V Patrone, Hong Dang, Hye-Seung Lee, Toby W Hurd, Heon Yung Gee, Edgar A Otto, Jan Halbritter, Stefan Kohl, Martin Kircher, Jeffrey Krischer, Michael J Bamshad, Deborah A Nickerson,16 Friedhelm Hildebrandt,Jay Shendure, Maimoona A Zariwala. Mutations in RSPH1 Cause Primary Ciliary Dyskinesia with a Unique Clinical and Ciliary Phenotype. Am J Respir Crit Care Med. 2014 Mar 15;189(6):707-17. doi: 10.1164/rccm.201311-2047OC.PMID:24568568

Austin-Tse C, Halbritter J, Zariwala MA, Gilberti RM, Gee HY, Hellman N, Pathak N, Liu Y, Panizzi JR, Patel-King RS, Tritschler D, Bower R, O’Toole E, Porath JD, Hurd TW, Chaki M, Diaz KA, Kohl S, Lovric S, Hwang DY, Braun DA, Schueler M, Airik R, Otto EA, Leigh MW, Noone PG, Carson JL, Davis SD, Pittman JE, Ferkol TW, Atkinson JJ, Olivier KN, Sagel SD, Dell SD, Rosenfeld M, Milla CE, Loges NT, Omran H, Porter ME, King SM, Knowles MR, Drummond IA, Hildebrandt F. Zebrafish Ciliopathy Screen Plus Human Mutational Analysis Identifies C21orf59 and CCDC65 Defects as Causing Primary Ciliary Dyskinesia. Am J Hum Genet. 2013 Oct 3;93(4):672-86.

Leonard J Lobo and Peadar G Noone. Infectious Considerations for Patients with Cystic Fibrosis Undergoing Lung Transplantation. The Lancet Respiratory Medicine 2013 doi:10.1016/S0140-6736(08)61345-8 (note this paper was featured on the cover with specially commissioned cover art).

LJ Lobo, LC Chang, CR Esther Jr., PH Gilligan, Z Tulu, and PG Noone (Sr Author). Lung Transplant Outcomes in Cystic Fibrosis Patients with Pre-Operative Mycobacterium abscessus Respiratory Infections. Clin Transplantation 2013: 27 (4); 523-9. DOI: 10.1111/ctr.12140.

D Antony, A Becker-Heck, MA Zariwala, M Schmidts, A Onoufriadis, M Forouhan, R Wilson, T Cox, A Dewar, C Jackson, P Goggin, NT Loges, H Olbrich, M Jaspers, M Jorissen, MW Leigh, WE Wolf, MLA Daniels, PG Noone, TW Ferkol, SD Sagel, M Rosenfeld, A Rutman, A Dixit, C O’Callaghan, JS Lucas, C Hogg, PJ Scambler, RD Emes, EMK Chung A Shoemark MR Knowles H Omran HM Mitchison. Mutations in CCDC39 and CCDC40 are the Major Cause of Primary Ciliary Dyskinesia with Axonemal Disorganization and Absent Inner Dynein Arms. Human Mutations. 2013 Mar;34(3):462-472.

Burrows E, Southern K, Noone PG. Sodium channel blockers for cystic fibrosis. Cochrane Database Syst Rev. 2014 Apr 9;4:CD005087. doi: 10.1002/14651858.CD005087.pub4.

Esther CR Jr, Esserman DA, Gilligan P, Kerr A, Noone PG. Chronic Mycobacterium abscessus infection and lung function decline in cystic fibrosis. J Cyst Fibros. 2010 Mar; 9(2):117-23.

Neuringer IP, Noone P, Cicale RK, Davis K, Aris RM. Managing complications following lung transplantation. Expert Rev Respir Med. 2009 Aug;3(4):403-23. doi: 10.1586/ers.09.27.

Amin R, Noone PG, Ratjen F.Cochrane Database Syst Rev. Chemical pleurodesis versus surgical intervention for persistent and recurrent pneumothoraces in cystic fibrosis. Cochrane Database Syst Rev. 2012 Dec 12;12: CD007481. doi: 10.1002/14651858.CD007481.pub3. Review. PMID: 23235645

Kennedy MP, Omran H, Leigh MW, Dell S, Morgan L, Zariwala MA, Molina PL, Minnix SL, Severin T, Ahrens P, Lange L, Noone PG, Knowles MR. Congenital heart disease and other heterotaxic defects in a large cohort of patients with primary ciliary dyskinesia. Circulation. 2007 Jun 5;115(22):2814-21.

Kennedy MP,Noone PG,Leigh MW, Zariwala MA, Minnix SL, Knowles MR, Molina PL. High-Resolution CT of Patients with Primary Ciliary Dyskinesia. Am J Roentgenol. 2007 May;188(5):1232-8.

Kennedy, M. P., P. G. Noone, J. Carson, P. L. Molina, A. Ghio, M. A. Zariwala, S. L. Minnix, and M. R. Knowles. 2007. Calcium stone lithoptysis in primary ciliary dyskinesia. Respir Med 101:76-83.

Zariwala MA, Leigh MW, Ceppa F, Kennedy MP, Noone PG, et al. Mutations of DNAII in primary ciliary dyskinesia: Evidence of founder effect in a common mutation. Am J Respir Crit Care Med. 2006; 174: 858-866.

Hornef N, Olbrich H, Horvath J, Zariwala MA, Fliegauf M, Loges NT, Wildhaber J, Noone PG, Kennedy M, Antonarakis SE, Blouin JL, Bartoloni L, Nublein T, Ahrens P, Griese M, Kuhl H, Sudbrak R, Knowles MR, Reinhardt R, Omran H. DNAH5 Mutations are a Common Cause of Primary Ciliary Dyskinesia with Outer Dynein Arm Defects. Am J Respir Crit Care Med. 2006; 174: 120-126

Macartney C, Burke E, Elborn S, Magee N, Noone PG, Gleadhill I, Allen D, Kettle P, Drake M. Department of Haematology. Bronchiolitis obliterans organizing pneumonia in a patient with non-Hodgkin’s lymphoma following R-CHOP and pegylated filgrastim. Leuk Lymphoma. 2005 Oct;46(10):1523-6.

Chmura K, Chan ED, Noone PG, Zariwala M, Winn RA, Knowles MR, Iseman MD, Gardner EM. A middle-aged woman with recurrent respiratory infections. Respiration. 2005 Jul-Aug;72 (4):427-30

Standaert TA, Boitano L, Emerson J, Milgram L, Konstan M, Hunter J, Bercalz PY, Brass-Ernst L, Zeitlin P, Hammond K, Davies Z, Foy C, Noone PG, Knowles MR. Standardized procedure for measurement of nasal potential difference: An outcome measure in multi-center Cystic Fibrosis clinical trials. Pediatr Pulmonol 2004; 37: 385-392

Zariwala M, O’Neal WK, Noone PG, Leigh MW, Knowles MR, Ostrowski LE. Investigation of the possible role of a novel gene, DPCD, in Primary Ciliary Dyskinesia. Am J Respir Cell Mol Biol. 2004; Apr; 30(4):428-34.

PG Noone: Leigh MW, Sannuti A, Minnix SL, Carson JL, Hazucha M, Zariwala M, Knowles MR. Primary ciliary dyskinesia: Diagnostic and phenotypic features. Am J Respir Crit Care Med 2004; 168:459-467.

Kispert A, Petry M, Olbrich H, Volz A, Ketelsen UP, Horvath J, Melkaoui R, Omran H, Zariwala M, Noone PG, Knowles M. Genotype-phenotype correlations in PCD patients carrying DNAH5 mutations. Thorax. 2003 Jun; 58(6):552-4.

Olbrich H, Haffner K, Kispert A, Volkel A, Volz A, Sasmaz G, Lehrach H, Konietzko N, Zariwala M, Noone PG, Knowles MR, Mitchison H, Chung E, Hildebrandt F, Sudbrak R, Omran H. Mutations of DNAH5 cause primary ciliary dyskinesia and randomization of left-right asymmetry. Nature Genetics 2002;30:143-144. [and http://www.nature.com/ng/]

Cohn JA, Noone PG, Jowell PS. Idiopathic pancreatitis related to CFTR: complex inheritance and identification of a modifier gene. J Investig Med 2002 ;50:247S-255S.

Noone PG, Zariwala M, Sannuti A, Minnix S, Leigh MW, Carson , Knowles MR. Mutations in DNAI1 (IC78) Cause Primary Ciliary Dyskinesia. Chest 2002; 121:97S-98S.

Noone PG, Knowles MR. CFTR-opathies”: Disease phenotypes associated with CFTR gene mutations. Respir Res 2001, 2: 328-332.

Southern KW, Noone PG, Bosworth DG, LeGrys VA, Knowles MR, Barker P. A modified technique for measurement of nasal transepithelial potential difference in infants. J Pediatr 2001; 139:353-358.

Noone PG, Zhou Z, Silverman LM, Jowell PS, Knowles MR, Cohn JA. Cystic Fibrosis Gene Mutations and Pancreatitis Risk: Relation to Epithelial Ion Transport and Trypsin Inhibitor Gene Mutations. Gastroenterology 2001; 121:1310-1315.

Noone PG, Zariwala M (co-first authors), Sannuti A, Minnix S, Zhou Z, Leigh MW, Hazucha M, Carson JL, Knowles MR. Germline Mutations in DNAI1 (IC78) Cause Primary Ciliary Dyskinesia. Am J Resp Cell Mol Biol 2001; 25:577-583.

Noone PG, Hamblett N, Accurso F, Aitken M, Boyle M, Dovey M, Gibson R, Johnson C, Kellerman D, Konstan M, Milgram L, Mundahl J, Rodman D, Williams JW, Wilmott R, Zeitlin P Ramsey B. Safety of aerosolized INS 365 in patients with mild to moderate cystic fibrosis: Results of a phase I multi-center study. Pediatr Pulmonol 2001; 32:122-128.

Noone PG, Pue CA, Zhou Z, Friedman KJ, Wakeling EL, Ganeshananthan M, Simon RH, Silverman LM, Knowles MR. Lung Disease associated with the IVS8 5T allele of the CFTR Gene. Am J Resp Crit Care Med 2000; 162:1919-1924.

Regnis J, Zeman KL, Noone PG, Knowles MR, Bennett WD. Prolonged airway retention of insoluble particles in cystic fibrosis versus primary ciliary dyskinesia. Adv Exp Biol. 2000; 26:149-162.

Noone PG, Hohneker KW, Gipson C, Foy C, Schwartzbach C, Efthimiou J, Pearlman R, Johnson LG, Zhou Z, Jones K, Noah TL, Leigh MW, Boucher RC, Knowles MR. Safety and biological efficacy of a lipid-CFTR complex for gene transfer in the nasal epithelium of adult patients with cystic fibrosis. Molecular Therapy. [The Journal of the Am Soc of Gene Therapy] 2000; 1: 105-114

Campbell, PW, Saiman, L editors, co-authors: …..Noone, PG….et al. Use of aerosolized antibiotics in CF patients: Chest 1999;116:775-788. Consensus statement (by invitation / peer reviewed).

Noone PG, Bennett WD, Regnis J, Zeman KL, Carson JL, Boucher RC, Knowles MR. Effects of aerosolized uridine-5’-triphosphate (UTP) on airway clearance during cough in patients with primary ciliary dyskinesia. Am J Resp Crit Care Med 1999;160:144-149.

Noone PG, Bali D, Carson JL, Sannuti A, Gipson CL, Ostrowski LE, Bromberg PA, Boucher RC, Knowles MR. Discordant organ laterality in monozygotic twins with Primary Ciliary Dyskinesia. Am J Med Genetics 1999; 82:155-160.

Cohn JA, Friedman KJ, Noone PG, Knowles MR, Silverman LM, Jowell PS. Relations between mutations in the cystic fibrosis gene and idiopathic pancreatitis. New England Journal of Medicine 1998;339:653-8.

Brinson G, Noone PG (senior corresponding author), Mauro M, Knowles MR, Yankaskas JR, Jacques P. Bronchial artery embolization for hemoptysis in cystic fibrosis. Am J Resp Crit Care Med 1998; 157:1951-1958.

Knowles MR, Noone PG, Hohneker KW, Johnson LG, Boucher RC, Efthimou J. Crawford, C, Brown R, Schwartzbach C, Pearlman R. A double blind placebo controlled dose ranging study to evaluate the safety and biologic efficacy of the lipid-DNA complex GR213487B in the nasal epithelium of adult patients with CF. Human Gene Therapy 1998; 9:249-269.

Noone PG, Regnis JA, Brouwer KR, Xinrong Liu, Robinson M, Knowles MR. Airway deposition and systemic pharmacokinetics of amiloride following aerosolization with an ultrasonic nebulizer to normal airways. Chest 1997;112:1283-1290.

Toso C, Williams D, Noone PG. Inhaled antibiotics in cystic fibrosis: A review. Annals of Pharmacotherapy 1996;30:840-50.

Knowles MR, Olivier K, Noone PG, Boucher RC. Pharmacologic modulation of salt and water in the airway epithelium in cystic fibrosis. Am J Respir Crit Care Med 1995;151:S65-S69.

Noone PG, King M, Loftus BG. Benign neonatal sleep myoclonus. Ir Med J 1995;88:172.

Knowles MR, Noone PG. Evaluation of the patient with borderline sweat test results. Ped Pulm 1994; 10: 141-2.

Noone PG, Olivier KN, Knowles MR. Modulation of the ionic milieu of the airway in health and disease. Annual Review of Medicine 1994;45: 421-434.

Noone PG, Knowles MR. Trends in therapy of abnormal airway epithelial ion and liquid transport. Monaldi Archives of Chest Diseases 1993; 48: 140-143.

Knowles MR, Olivier KN, Hohneker K, Noone PG, Mason S, Boucher RC. Acute safety an effects of aerosolized uridine 5-triphosphate (UTP) plus or minus amiloride. Ped Pulm 1993; 9:148-9.

Noone PG, O’ Briain DS, Clancy L. Adenocarcinoma of the lung in association with chronic sarcoidosis. Ir Med J 1993; 86: 27-28.

Tyrell J, Noone PG, Prichard JS. Thoracic actinomycosis complicated by actinobacillus actinomycetemcomitans. Respiratory Medicine 1992; 86: 341-343.

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