Heart failure; cardiac transplantation; echocardiography; heart biopsies. Research includes heart failure surveillance and epidemiology; peripartum cardiomyopathy; cardiac transplantation outcomes; clinical trials.
Education and Experience
BS magna cum laude: Yale University, 1990; MD: Johns Hopkins University, 1995; Intern and Resident: Johns Hopkins University, 1995-1998; Cardiology Fellowship: Johns Hopkins, 1998-2002; MHS in Epidemiology: Johns Hopkins, 2001; Assistant Professor of Medicine: University of North Carolina, 2002-2010; Adjunct Assistant Professor of Epidemiology: University of North Carolina, 2003-2010; Director, Advanced Heart Failure & Transplant Cardiology Fellowship: University of North Carolina, 2002-present; Director, Heart Failure & Transplant Service: University of North Carolina, 2002-present; Primary Transplant Physician, UNC Heart and Heart/Lung Transplant Program: University of North Carolina, 2003-present; Director, Heart Failure and Transplantation Program: University of North Carolina, 2009-present; Adjunct Associate Professor of Epidemiology: University of North Carolina, 2010-present; Associate Professor of Medicine: University of North Carolina, 2010-2020. Professor of Medicine: University of North Carolina, 2020-present.
Clinical and Research Interests
Dr. Chang’s clinical practice is focused on advanced heart failure, cardiac transplantation, and echocardiography. She is currently a Professor of Medicine in the Division of Cardiology and Director of the Heart Failure and Transplantation Program at the University of North Carolina (UNC) at Chapel Hill. She also serves as the Program Director for UNC’s Advanced Heart Failure and Transplant Cardiology subspecialty fellowship.
Her research is based in heart failure, focused on epidemiology and outcomes. She has an adjunct appointment in the Department of Epidemiology at the UNC School of Public Health and is a co-investigator on the NIH-funded Atherosclerosis Risks in Communities (ARIC) Study.
Chang PP. The Last Year in Patients With Heart Failure: More Than Just Heart. JACC Heart Fail. 2019 Jul;7(7):571-573. (PMID: 31248568)
Byku M, Chang PP. Desensitization for sensitized patients awaiting heart transplant. Curr Opin Organ Transplant. 2019 Jun;24(3):233-238. (PMID:31090629)
Chang PP, Wruck LM, Shahar E, Rossi JS, Loehr LR, Russell SD, Agarwal SK, Konety SH, Rodriguez CJ and Rosamond WD. Trends in Hospitalizations and Survival of Acute Decompensated Heart Failure in Four US Communities (2005-2014): The Atherosclerosis Risk in Communities (ARIC) Study Community Surveillance. Circulation. 2018 Jul 3;138(1):12-24. (PMID: 29519849)
Folsom AR, Shah AM, Lutsey PL, Roetker NS, Alonso A, Avery CL, Miedema MD, Konety S, Chang PP, Solomon SD. American Heart Association’s Life’s Simple 7: Avoiding Heart Failure and Preserving Cardiac Structure and Function. American Journal of Medicine 2015 Sep;128(9):970-6.e2. (PMID: 25908393)
Sueta CA, Rodgers JE, Chang PP, Zhou L, Thudium EM, Kucharska-Newton AM, Stearns SC. Medication Adherence Based on Part D Claims for Patients With Heart Failure After Hospitalization (from the Atherosclerosis Risk in Communities Study) American Journal of Cardiology 2015 Aug 1;116(3):413-9. (PMID: 26026867)
Katz JN, Jensen BC, Chang PP, Myers SL, Pagani FD, Kirklin JK. A multicenter analysis of clinical hemolysis in patients supported with durable, long-term left ventricular assist device therapy. Journal of Heart and Lung Transplantation 2015 May;34(5):701-9. (PMID: 25582036)
Rodriguez CJ, Swett K, Agarwal SK, Folsom AR, Fox ER, Loehr LR, Ni H, Rosamond WD, Chang PP. Systolic Blood Pressure Levels among Hypertensives and Incident Cardiovascular Events: The Atherosclerosis Risk in Communities Study. JAMA Internal Medicine 2014 Aug 1;174(8):1252-61. (PMID: 24935209)
Higgins RS, Brown RN, Chang PP, Starling RC, Ewald GA, Tallaj JA, Kirklin JK, George JF. A Multi-institutional Study of Malignancies After Heart Transplantation and a Comparison to the General U.S. Population. Journal of Heart and Lung Transplantation 2014 May;33(5):478-85. (PMID: 24630406)
Chang PP, Chambless LE, Shahar E, Bertoni AG, Russell SD, Ni H, He M, Mosley TH, Wagenknecht LE, Samdarshi TE, Wruck LM, Rosamond WD. Incidence and Survival of Hospitalized Acute Decompensated Heart Failure in Four US Communities (from the Atherosclerosis Risk in Communities Study). American Journal of Cardiology 2014 Feb 1;113(3):504-10. (PMID: 24342763)