Coagulation proteases in the pathology of cardiovascular diseases, hematologic disorders and neuroinflammation, Sickle Cell Disease
Research and Clinical Interests
Dr. Pawlinski is interested in the role of coagulation proteases in the pathology of cardiovascular diseases, hematologic disorders and neuroinflammation.
In addition to playing an important role in hemostasis and thrombosis, coagulation proteases induce various cellular responses via proteolytical cleavage of protease activated receptors (PARs). He is especially interested in the role of PARs in mediating the crosstalk between coagulation and inflammation. Using both in vitro and in vivo approaches, he is trying to understand the molecular mechanism by which PARs contribute to the pathophysiology of myocardial infarction, ischemia reperfusion injury- induced heart remodeling, sickle cell disease and amyotrophic lateral sclerosis.