Interventional cardiology; Vascular biology; Smooth muscle cell growth regulation, particularly integrin/cytoskeletal interactions; Regulation of thrombin and thrombus formulation during interventions; Cardiovascular hemodynamics.
Education and Experience
BS Magna Cum Laude: Bucknell University, 1980; MD: University of Maryland, 1987; Resident: University of Virginia, 1987-1990; Cardiovascular Research Fellow: University of Virginia, 1990-1992; Clinical Cardiology Fellow: University of Virginia, 1992-1994; Interventional Cardiology Fellow: University of Virginia, 1994-1995. Clinical Instructor in Medicine: University of Virginia, 1994-1995; Assistant Professor of Medicine: University of Texas, 1995-1999; Principal Investigator, University of Texas, 1995-2000; Co-Director Clinical Research: University of Texas, 1996-2000; Associate Director of Cardiac Catheterization Lab: University of Texas, 1997-2000; Associate Professor of Medicine: University of Texas, 1999-2000; Associate Professor of Medicine: University of North Carolina, 2000-2004; Vice Chief of Cardiology for Clinical Affairs: University of North Carolina, 2005-2007; Director of Interventional Cardiology: University of North Carolina, 2001-2015; Director of the C.V. Richardson Cardiac Cath Lab; University of North Carolina, 2001-2015; Professor of Medicine: University of North Carolina, 2004-present; Henry A. Foscue Distinguished Professor of Medicine: University of North Carolina, 2005-2018; Chief of Clinical Cardiology: University of North Carolina, 2007-2013; Director of Cardiovascular Outreach: University of North Carolina, 2009-present; Chief, Division of Cardiology, University of North Carolina, 2013-present; Physician-in-Chief, UNC Heart & Vascular Service Line, 2015-present; Co-Director, McAllister Heart Institute, 2017; Ernest and Hazel Craige Distinguished Professor of Medicine, 2018-present.
Clinical and Research Interests
Dr. Stouffer is an active clinician with a focus on smooth muscle cell growth regulation. He also has an interest in new treatments for hypertension, with his work being cited in multiple medical publications. His study on survival rates for in-hospital heart attacks was featured in The Wall Street Journal.
With a strong research emphasis on advanced interventional cardiology treatments and procedures, Dr. Stouffer also studies coronary and peripheral interventions. He has also focused additional research on hemodynamics, valvular heart disease, coronary artery disease, renal artery stenosis, acute coronary syndromes, and stents.
Zhou R and Stouffer GA. Is time of renal hypoperfusion an important variable in determining response to renal artery revascularization? JACC-Cardiovascular Interventions 2014;7:110.
Kaul P, Federspiel JJ, Dai X, Stearns SC; Smith Jr, SC; Yeung M; Beyhaghi H, Zhou L, Stouffer GA. Association of inpatient-onset vs outpatient-onset of ST elevation myocardial infarction with treatment and clinical outcomes. JAMA 2014;312:1999-2007.
Lee JA, Lee CR, Reed BN, Plitt DC, Polasek MJ, Howell LA, Cicci JD, Tasca KE, Weck KE, Rossi JS, Stouffer GA. Implementation and evaluation of a CYP2C19 genotype-guided antiplatelet therapy algorithm in high-risk coronary artery disease patients. Pharmacogenomics 2015;16:303-313.
Dai X, Kaul P, Smith SC, Stouffer GA. Predictors, Treatment and Outcomes of Inpatient ST Elevation Myocardial Infarction. Nat Rev Cardiol 2016;13:148-154.
Rommel JJ, Yadav PK and Stouffer GA. Causes and Hemodynamic Findings in Chronic Severe Pulmonary Regurgitation. Cathet Cardiovasc Intervent 2015;Jun 23.
Pathak AS, Huang J, Rojas M, Bazemore TC, Zhou R, Stouffer GA. Effects of Restoration of Blood Flow on the Development of Aortic Atherosclerosis in ApoE−/− Mice With Unilateral Renal Artery Stenosis. J Am Heart Assoc. 2016 Apr 3;5(4):e002953.
Dai X, Meredith D, Sawey E, Kaul P, Smith SC Jr, Stouffer GA. A Quality Improvement Program for Recognition and Treatment of Inpatient ST-Segment Elevation Myocardial Infarctions. JAMA Cardiol. 2016 Dec 1;1(9):1077-1079.
Johnson PM, Madamanchi C, Sharalaya Z, Iqbal Z, Gehi A, Kaul P, Stouffer GA. Angiographic severity does not correlate with fractional flow reserve in heavily calcified coronary arteries. Catheter Cardiovasc Interv. 2017 Feb 1;89(2):226-232.
Arora S, Strassle PD, Qamar A, Wheeler EN, Levine AL, Misenheimer JA, Cavender MA, Stouffer GA, Kaul P. Impact of Type 2 Myocardial Infarction (MI) on Hospital-Level MI Outcomes: Implications for Quality and Public Reporting. J Am Heart Assoc. 2018 Mar 26;7(7).