Ruihai Zhou, MD, MSc, FACC, RPVI

Assistant Professor of Medicine, Division of Cardiology
UNC Cardiology/Nash Heart Center

Specialty areas: Prevention, diagnosis, and treatment of cardiovascular and peripheral vascular diseases; cardiac catheterization; percutaneous coronary artery intervention; percutaneous peripheral vascular intervention; noninvasive cardiac stress testing and vascular imaging diagnosis.

Chronology: MD: Binzhou Medical College, Shandong, China, 1985; MSc: Pharmacology, School of Medicine, Shandong University, China, 1988; Residency (internal medicine): Shandong University Qilu Hospital, China, 1988-1991; medical scholarship awardee scientist (clinical pharmacology and therapeutics): Oita Medical University, Japan (Japan Sasagawa Medical Scholarship), 1991-1992; attending physician (internal medicine/geriatrics): Shandong University Qilu Hospital, China, 1992-1999; Japan Science and Technology Agency (STA) Fellowship Awardee scientist (molecular and genetic cardiovascular research): National Cardiovascular Center, Osaka, Japan, 1999-2001; Attending physician (internal medicine/geriatrics): Shandong University Qilu Hospital, China, 2001; Postdoctoral researcher (cardiovascular biomedical research): Division of Biomedical Sciences, University of California, Riverside, CA, 2001-2004; Postdoctoral researcher (translational medicine in cardiovascular disease): The Center for Translational Medicine, Thomas Jefferson University, Philadelphia, PA, 2004-2005; Instructor (faculty, translational medicine in cardiovascular disease): The Center for Translational Medicine, Thomas Jefferson University, Philadelphia, PA, 2005-2006; Medical resident (internal medicine): Greenwich Hospital/Yale University School of Medicine, 2006-2009; Clinical Cardiology/Physician Scientist Fellow: University of North Carolina at Chapel Hill School of Medicine, 2009-2013; Interventional Cardiology Fellow: University of North Carolina at Chapel Hill School of Medicine, 2013-2014; Adjunct Assistant Professor of Medicine, Cardiology: Caldwell Memorial Hospital, University of North Carolina Health Care, 2014-2016; Assistant Professor of Medicine: Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, 2016-present.

Board certified by the American Board of Internal Medicine in Internal Medicine, Cardiovascular Disease, and Interventional Cardiology, as well as certified by the American Registry for Diagnostic Medical Sonography as a Registered Physician in Vascular Interpretation (RPVI).

Honors and awards:

Japan Sasagawa Medical Scholarship (clinical pharmacology and therapeutics), 1991-1992.
Japan Government Science & Technology Agency (STA) Fellowship (molecular and genetic cardiovascular research), 1999-2001.
American Heart Association Grant-in-Aid, 2006-2008. Role of Sterol Response Element-binding Protein in Postintervention Vascular Restenosis. (AHA ID #:0665450U).
Resident Teacher of The Year (the only awardee of the year), Greenwich Hospital/Yale University School of Medicine, 2009.

Selected bibliography:

Pathak AS, Huang J, Rojas M, Bazemore TC, Zhou R, Stouffer GA. Effects of Restoration of Blood Flow on the Development of Aortic Atherosclerosis in ApoE-/- Mice With Unilateral Renal Artery Stenosis. J Am Heart Assoc. 2016 Apr 3;5(4).

Yin W, Li B, Li X, Yu F, Cai Q, Zhang Z, Wang J, Zhang J, Zhou R, Cheng M, Gao H. Critical role of prohibitin in endothelial cell apoptosis caused by glycated low-density lipoproteins and protective effects of grape seed procyanidin B2. J Cardiovasc Pharmacol. 2015 Jan;65(1):13-21

Zhou RH, Stouffer GA. Is time of renal hypoperfusion an important variable in determining response to renal artery revascularization? JACC Cardiovasc Interv. 2014 Jan; 7(1):110

Li XL, Li BY, Cheng M, Yu F, Yin WB, Cai Q, Zhang Z, Zhang JH, Wang JF, Zhou RH, Gao HQ. PIMT prevents the apoptosis of endothelial cells in response to glycated low density lipoproteins and protective effects of grape seed procyanidin B2. PLoS One. 2013 Jul 26;8(7):e69979.

Zhou RH, Vendrov AE, Tchivilev I, Niu X-L, Molnar KC, Rojas M, Stouffer GA, Madamanchi NR, Runge MS. Mitochondrial oxidative stress in aortic stiffening with age: The role of smooth muscle cell function. Arteriosclerosis Thrombosis and Vascular Biology. 2012 Mar 32(3):745-55.

Zhou RH, Frishman WH. The anti-platelet effect of nitrates: Is it of clinical benefit in patients with cardiovascular disease? (Invited review). Cardiology in Review. 2010 July/Aug;18(4): 198-203.

Zhou RH, Pesant S, Cohn H, Soltys S, Koch WJ, Eckhart AD. Negative regulation of VEGF signaling in human coronary artery endothelial cells by G protein-coupled receptor kinase 5. Clinical and Translational Science. 2009 Feb; 2(1): 57-61.

Zhou RH*(Co-1st author), Keys JR*, Harris DM, et al. Vascular smooth muscle overexpression of G protein-coupled receptor kinase 5 elevates blood pressure, which segregates with sex and is dependent on Gi-mediated signaling. Circulation. 2005 Aug; 112:1145-1153.

Zhou RH, Min Yao, Tzong-Shyuan Lee, Yi Zhu, Manuela Martins-Green, John Y.-J. Shyy. Vascular endothelial growth factor activation of sterol regulatory element binding protein: A potential role in angiogenesis. Circulation Research. 2004 July; 95:471-478.

  • Phone Number

    252-962-8202 (Office Phone)

  • Address

    Nash Heart Center

    2460 Curtis Ellis Dr.

    Rocky Mount, NC 27804