Sriram Machineni, MD

Assistant Professor, Division of Endocrinology & Metabolism
Director, UNC Medical Weight Clinic

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Specialty Areas

Clinical: Multidisciplinary management of obesity, safe use of anti-obesity medications, and management of post bariatric medical complications including nutritional deficiencies, hypoglycemia, weight regain, etc.

Chronology

MD: All India Institute of Medical Sciences, 1992-1997; Internal Medicine Residency: State University of New York At Buffalo, 1999-2002; Chief Medical Residency: Buffalo General Hospital 2002-2003, Clinical Assistant Professor of Medicine: State University of New York at Buffalo 2003-2008; Voluntary Research Fellow: Columbia University, 2008-2010; Clinical Fellow in Obesity Medicine: Harvard University, Massachusetts General Hospital, 2010-2011; Post-doctoral Research Fellowship: Massachusetts General Hospital: 2011-2013, Instructor In Medicine: Harvard University, 2013-2017; Assistant Professor of Medicine: University of North Carolina at Chapel Hill, 2017-present; Director: UNCH Medical Weight Center, 2017-present.

The clinical program for the management of obesity at the UNCH medical weight Center is based on the principles embodied in the research and education endeavors. Strategies for treatment are based on leveraging heterogeneity of response to treatments and the use of multimodality options as appropriate for the degree of health impairment caused by the individual’s obesity. The strategies build on the resources already present in the UNC medical community to make a truly integrated program for the local patient population.

Dr. Machineni’s research examines mechanisms of energy balance and body fat regulation, determination of predictors for heterogeneity of response to obesity treatments, and clinical trials of new anti-obesity medications

Prior to coming to the University of North Carolina Chapel Hill, Dr. Machineni studied energy balance and body fat regulation in animal models with genetic, nutritional and bariatric surgical manipulations allowing the interpretation of clinical research findings and phenotypes in the context of physiology.  Drawing on this experience, he will focus on building a multi-disciplinary clinical research program to explore heterogenous patient response to obesity treatments and help develop personalized obesity medicine strategies incorporating genotypic, metabolomic and microbiota signatures. To date, Dr. Machineni is the only physician with a Castle Connolly distinction for obesity medicine in the Triangle area.

Selected Bibliography

Kushner RF, Butsch WS, Kahan S, Machineni S, Cook S, Aronne LJ. Obesity Coverage on Medical Licensing Examinations in the United States. What is Being Tested? Teaching and Learning in Medicine, 2016. Dec 29:1-6. doi: 10.1080/10401334.2016.1250641. PMID 28033472.

Carmody JS, Ahmad NN, Machineni S, Lajoie S, Kaplan LM. Weight loss after RYGB is independent of and complementary to serotonin 2C receptor signaling in male mice. Endocrinology, 2015. Sep;156(9):3183-91. PMID: 26066076.

Liou AP, Paziuk M, Luevano JM Jr, Machineni S, Turnbaugh PJ, Kaplan LM. Conserved shifts in the gut microbiota due to gastric bypass reduce host weight and adiposity. Sci Transl Med., 2013..Mar 27; 5(178):178ra41. PMID: 23536013.

Bose M, Machineni S, Oliván B, Teixeira J, McGinty JJ, Bawa B, Koshy N, Laferrère B. Superior appetite hormone profile after equivalent weight loss by gastric bypass compared to gastric banding. Obesity, 2010. 18(6):1085-91. PMID: 20057364.

Bose M, Teixeira J, Oliván B, Bawa B, Arias S, Machineni S, Pi-Sunyer FX, Scherer PE, Laferrère B. Weight loss and incretin responsiveness improve glucose control independently after gastric bypass surgery. J Diabetes, 2010. 2(1):47-55. PMID: 20676394.

 

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