Education and Experience
MD with High Honors: Baylor College of Medicine, 1973, Intern: Baylor Affiliated Hospitals, 1974, Houston, TX; Residency and Fellowship: Peter Bent Brigham Hospital/Harvard Medical School, Boston, MA, 1975-1980, Professor of Medicine: University of North Carolina, 2019-present.
I am interested in the mechanisms and predictors of the progression of chronic kidney disease and in the potentially toxic substances retained in kidney failure.
Hostetter TH, Troy JL, and Brenner BM. Glomerular function in experimental diabetes mellitus in rats: Hemodynamic basis for hypo-and hyperfiltration. Kidney International 19:410, 1981.
Hostetter TH, Olson JL, Rennke HG, Venkatachalam MA, and Brenner BM. Hyperfiltration in remnant nephrons: A potentially adverse response to renal ablation. American Journal of Physiology 241:F85-F93, 1981.
Nath KA, Hostetter MK, and Hostetter TH. Pathophysiology of chronic tubulo-interstitial disease in rats: Interactions of dietary acid load, ammonia, and complement component C3. Journal of Clinical Investigation 76:667-675, 1985
Shafi T, Powe NR, Meyer TW, Hwang S, Hai X, Melamed ML, Banerjee T, Coresh J, Hostetter TH. Trimethylamine N-Oxide and Cardiovascular Events in Hemodialysis Patients. J Am Soc Nephrol. 28:321-331, 2017.
Melamed ML, Dobre MA, HorwitzE, Abramowitz M, Hostetter TH. The Effects of Sodium Bicarbonate in Chronic Kidney Disease Stages 3 and 4: A Randomized, Placebo-Control, Multi-Center Clinical Trial. AM J Kid Dis in press