Stephen Tilley, MD

Associate Professor of Medicine, Division of Pulmonary Diseases and Critical Care Medicine

Specialty Areas: general pulmonary medicine (asthma, COPD, bronchiectasis, obstructive sleep apnea, interstitial lung diseases, cough, dyspnea) and critical care medicine

Chronology: BA: University of North Carolina, Chapel Hill, N.C. (1988); MD: University of North Carolina, Chapel Hill, N.C. (1992); Residency: Vanderbilt University, Nashville, TN (1995); Fellowship University of North Carolina, Chapel Hill, N.C. (1998)

Dr. Tilley’s research interests include:

1. Asthma pathogenesis
2. Mechanisms of airway hyperresponsiveness in asthma
3. Pre-clinical evaluation of novel therapies for asthma and other lung diseases

Dr. Tilley joined the faculty of University of North Carolina School of Medicine in 1999 and currently serves as Director of the UNC Sanford Pulmonary Clinic, an outreach clinic providing pulmonology services to patients in south-central North Carolina. His research interests include basic and translational research in the pathogenesis of asthma and other chronic lung diseases. His research is supported by grants funded by the NIH, NIEHS, FDA, and American Asthma Foundation. He has a particular interest in how the upper and lower airways interact to promote lung disease, and how mast cells and environmental pollutants influence airway disease pathogenesis. He is a member of the UNC Center for Environmental Medicine, Asthma, and Lung Biology where he serves as the director of the Center’s animal model’s core. Dr. Tilley is a member of the American Thoracic Society and the American Lung Associations Allergy and Immunology Study Section.

Selected Bibliography:

1. Hua X, Naselsky WC, Jania CM, Chason KD, Doerschuk CM, Graham SM, Senior BA, Tilley SL. Mast cell deficiency limits the development of chronic rhinosinusitis in mice. Annals of Otology, Rhinology & Laryngology. In press. 2015.

2. Sorrentino JA, Krishnamurthy J, Tilley SL, Alb JG Jr, Burd CE, Sharpless NE. p16INK4a reporter mice reveal age-promoting effects of environmental toxicants. J Clin Invest. 2014. Jan;124(1):169-73. PMID: 24334456

3. Li M, Wetzel-Strong SE, Hua X, Tilley SL, Oswald E, Krummel MF, Caron KM. Deficiency of RAMP1 attenuates antigen-induced airway hyperresponsiveness in mice. PLoS One. 2014 Jul 10;9(7):e102356. PMID: 25010197

4. Hua X, Chason K, Jania C, Acosta T, Ledent C, Tilley SL. Gs-coupled adenosine receptors differentially limit antigen-induced mast cell activation. J Pharmacol Exp Ther. 2013 Feb; 344(2):426-35. PMID: 23149337

5. Allen IC, Lich JD, Arthur JC, Jania CM, Roberts RA, Callaway JB, Tilley SL, Ting JP. Characterization of NLRP12 during the development of allergic airway disease in mice. PLoS One. 2012; 7:e30612 PMID: 22248128

6. Allen IC, Jania CM, Wilson JE, Tekeppe EM, Hua X, Brickey WJ, Kwan M, Koller BH, Tilley SL, Ting JP. Analysis of NLRP3 in the development of allergic airway disease in mice. J Immunol. 2012; 188:2884-93. PMID: 22279123

7. Hua X, Chason KD, Patel JY, Naselsky WC, Tilley SL. IL-4 amplifies the pro-inflammatory effect of adenosine in human mast cells by changing expression levels of adenosine receptors. PLoS One. 2011;6:e24947. PMID: 21966389

8. Kovarova M, Latour AM, Chason KD, Tilley SL, Koller BH. Human embryonic stem cells: a source of mast cells for the study of allergic and inflammatory diseases. Blood. 2010; 115:3695-703. PMID: 20200352

9. Jaspers I, Sheridan PA, Zhang W, Brighton LE, Chason KD, Hua X, Tilley SL. Exacerbation of allergic inflammation in mice exposed to diesel exhaust particles prior to viral infection. Part Fibre Toxicol. 2009; 6:22. PMID: 19682371

10. Hua X, Chason KD, Fredholm BB, Deshpande DA, Penn RB, Tilley SL. Adenosine induces airway hyperresponsiveness through activation of A3 receptors on mast cells. J Allergy Clinical Immunol. 2008; 122:107-13. PMID: 18472152

11. Mall MA, Harkema JR, Trojanek JB, Treis D, Livraghi A, Schubert S, Zhou Z, Kreda SM, Tilley SL, Hudson EJ, O’Neal WK, Boucher RC. Development of chronic bronchitis and emphysema in βENaC overexpressing mice. Am J Respir Crit Care Med. 2008; 177:730- 42. PMID: 18079494

12. Hua X, Erikson CJ, Chason KD, Rosebrock CN, Deshpande DA, Penn RB, Tilley SL. Involvement of A1 adenosine receptors and neural pathways in adenosine induced bronchoconstriction in mice. Am J Physiol Lung Cell Mol Physiol. 2007; 293(1):L25-32. PMID: 17468137

13. Tilley SL, Jaradat M, Stapleton C, Dixon D, Hua X, Erikson CJ, McCaskill JG, Chason, KD, Liao G, Jania L, Koller BH, Jetten AM. Retinoid-related orphan receptor gamma controls immunoglobulin production and Th1/Th2 cytokine balance in the adaptive immune response to allergen. J Immunol. 2007; 178:3208-18. PMID: 17312169

14. Hua, X, Kovarova M, Chason KD, Nguyen M, Koller BH, Tilley SL. Enhanced mast cell activation in mice deficient in the A2B adenosine receptor. J Exp Med. 2007; 204:117-28. PMID: 17200408

15. Jaradat M, Stapleton C, Tilley SL, Dixon D, Erikson CJ, McCaskill JG, Kang HS, Angers M, Liao G, Collins J, Grissom S, Jetten AM. Modulatory role for retinoid-related orphan receptor alpha in allergen-induced lung inflammation. Am J Respir Crit. Care Med. 2006; 174:1299-309. PMID: 16973978