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This novel, randomized clinical trial will evaluate if vitamin K supplementation impacts pain and function in patients with knee OA who are vitamin K insufficient.

There is a growing body of epidemiological, genetic and biochemical evidence that vitamin K plays a role in maintaining joint health.

The study will provide initial data in support of a larger confirmatory trial to determine if vitamin K supplementation can slow functional decline and reduce pain in this patient population.

Dr. Sarah Booth, PI, is Director of the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University (HNRCA). Dr. Richard Loeser, Co-PI, is Director of the UNC Thurston Arthritis Research Center, and is the Joseph P. Archie, Jr. Eminent Professor of Medicine in the UNC Division of Rheumatology, Allergy and Immunology.