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Matthew C. Foster, MD

Matthew Foster, MD, associate professor of medicine in the division of hematology, is the lead author of a new study published in the journal Blood about the successful use of an experimental safety switch, incorporated as part of a chimeric antigen receptor T-cell (CAR-T) therapy, to reduce the severity of treatment side effects that sometimes occur. This advance was seen in a patient enrolled in a clinical trial using CAR-T to treat refractory acute B-cell leukemia. It demonstrates a proof-of-principle for possible expanded use of CAR-T immunotherapy paired with the safety switch.

Read more from UNC Lineberger Comprehensive Cancer Center.