BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Department of Medicine - ECPv6.15.18//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-ORIGINAL-URL:https://www.med.unc.edu/medicine
X-WR-CALDESC:Events for Department of Medicine
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:America/New_York
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20160313T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20161106T060000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20170312T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20171105T060000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20180311T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20181104T060000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20171010T140000
DTEND;TZID=America/New_York:20171010T150000
DTSTAMP:20260412T092545
CREATED:20171010T180000Z
LAST-MODIFIED:20190307T185828Z
UID:10000930-1507644000-1507647600@www.med.unc.edu
SUMMARY:MHI Seminar Series: Kari North\, PhD\, Genetic Diversity Turns a New PAGE in Our Understanding of Complex Traits
DESCRIPTION:Speaker: Kari North\, PhDTopic: Genetic Diversity Turns a New PAGE in Our Understanding of Complex Traits \nPresentation Preview: Genome-wide association studies (GWAS) have laid the foundation for many downstream investigations\, including the biology of complex traits\, drug development\, and clinical guidelines. However\, the dominance of European-ancestry populations in GWAS creates a biased view of human variation and hinders the translation of genetic associations into clinical and public health applications. To demonstrate the benefit of studying underrepresented populations\, the Population Architecture using Genomics and Epidemiology (PAGE) study conducted a GWAS of 26 clinical and behavioral phenotypes in 49\,839 non-European individuals. Using novel strategies for multi-ethnic analysis of admixed populations\, we confirm 574 GWAS catalog variants across these traits\, and find 28 novel loci and 42 residual signals in known loci. Our data show strong evidence of effect-size heterogeneity across ancestries for published GWAS associations\, which substantially restricts genetically-guided precision medicine. We advocate for new\, large genome-wide efforts in diverse populations to reduce health disparities.
URL:https://www.med.unc.edu/medicine/event/mhi-seminar-series-kari-north-phd-genetic-diversity-turns-a-new-page-in-our-understanding-of-complex-traits/
CATEGORIES:Medicine Grand Rounds
END:VEVENT
END:VCALENDAR