BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Department of Medicine - ECPv6.15.18//NONSGML v1.0//EN CALSCALE:GREGORIAN METHOD:PUBLISH X-ORIGINAL-URL:https://www.med.unc.edu/medicine X-WR-CALDESC:Events for Department of Medicine REFRESH-INTERVAL;VALUE=DURATION:PT1H X-Robots-Tag:noindex X-PUBLISHED-TTL:PT1H BEGIN:VTIMEZONE TZID:America/New_York BEGIN:DAYLIGHT TZOFFSETFROM:-0500 TZOFFSETTO:-0400 TZNAME:EDT DTSTART:20160313T070000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0400 TZOFFSETTO:-0500 TZNAME:EST DTSTART:20161106T060000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:-0500 TZOFFSETTO:-0400 TZNAME:EDT DTSTART:20170312T070000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0400 TZOFFSETTO:-0500 TZNAME:EST DTSTART:20171105T060000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:-0500 TZOFFSETTO:-0400 TZNAME:EDT DTSTART:20180311T070000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0400 TZOFFSETTO:-0500 TZNAME:EST DTSTART:20181104T060000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:-0500 TZOFFSETTO:-0400 TZNAME:EDT DTSTART:20190310T070000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0400 TZOFFSETTO:-0500 TZNAME:EST DTSTART:20191103T060000 END:STANDARD END:VTIMEZONE BEGIN:VTIMEZONE TZID:America/New_York BEGIN:DAYLIGHT TZOFFSETFROM:-0500 TZOFFSETTO:-0400 TZNAME:EDT DTSTART:20170312T070000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0400 TZOFFSETTO:-0500 TZNAME:EST DTSTART:20171105T060000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:-0500 TZOFFSETTO:-0400 TZNAME:EDT DTSTART:20180311T070000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0400 TZOFFSETTO:-0500 TZNAME:EST DTSTART:20181104T060000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:-0500 TZOFFSETTO:-0400 TZNAME:EDT DTSTART:20190310T070000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0400 TZOFFSETTO:-0500 TZNAME:EST DTSTART:20191103T060000 END:STANDARD END:VTIMEZONE BEGIN:VEVENT DTSTART;TZID=America/New_York:20171106T120000 DTEND;TZID=America/New_York:20171106T130000 DTSTAMP:20260414T170507 CREATED:20171106T170000Z LAST-MODIFIED:20190307T185812Z UID:10000941-1509969600-1509973200@www.med.unc.edu SUMMARY:Cardiovascular Grand Rounds: Craig R. Lee\, PharmD\, PhD\, Clinical outcomes and sustainability of using CYP2C19 genotype-guided antiplatelet therapy after percutaneous coronary intervention DESCRIPTION:Speaker: Craig R. Lee\, Pharm.D.\, Ph.D.\, FCCP\, FAHA. Associate Professor of Pharmacy\, Division of Pharmacotherapy and Experimental Therapeutics\, UNC Eshelman School of PharmacyTopic: Clinical outcomes and sustainability of using CYP2C19 genotype-guided antiplatelet therapy after percutaneous coronary intervention URL:https://www.med.unc.edu/medicine/event/cardiovascular-grand-rounds-craig-r-lee-pharmd-phd-clinical-outcomes-and-sustainability-of-using-cyp2c19-genotype-guided-antiplatelet-therapy-after-percutaneous-coronary-intervention/ LOCATION:NC CATEGORIES:Medicine Grand Rounds END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20171107T140000 DTEND;TZID=America/New_York:20171107T150000 DTSTAMP:20260414T170507 CREATED:20171107T190000Z LAST-MODIFIED:20190307T185810Z UID:10000944-1510063200-1510066800@www.med.unc.edu SUMMARY:McAllister Heart Institute Seminar Series: Hong Chen\, PhD\, Molecular Mechanisms Regulating VEGF Receptor Trafficking DESCRIPTION:Speaker: Hong Chen\, PhD\, Associate Professor Dept. of Surgery\, Harvard Medical School\, Boston Children’s HospitalTopic: Molecular Mechanisms Regulating VEGF Receptor Trafficking URL:https://www.med.unc.edu/medicine/event/mcallister-heart-institute-seminar-series-hong-chen-phd/ LOCATION:NC CATEGORIES:Medicine Grand Rounds END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20171109T120000 DTEND;TZID=America/New_York:20171109T130000 DTSTAMP:20260414T170507 CREATED:20171109T170000Z LAST-MODIFIED:20190307T185807Z UID:10000831-1510228800-1510232400@www.med.unc.edu SUMMARY:Medicine Grand Rounds\, Roy Williams\, "Leadership" DESCRIPTION:Roy Williams is entering his 15th season as head coach of the Tar Heels. He has achieved great success on the court\, winning his third NCAA title in 2017\, appearing in nine Final Fours (five with UNC) and earning eight Atlantic Coast Conference regular-season titles. Even greater is the impact he makes on the lives of the young men he coaches. \nRoy Williams received the Nell and John Wooden Leadership in Coaching Award on October 12\, 2017. This award\, named after legendary UCLA basketball coach John Wooden and his wife\, Nell\, was created in 2012 to recognize coaches who exemplify Wooden’s “Pyramid of Success” teachings both on and off the court. \nThe numbers and list of Williams’ accomplishments unquestionably place him among the finest coaches in basketball history. Williams is one of six coaches to win three or more national championships with John Wooden\, Mike Krzyzewski\, Jim Calhoun\, Bob Knight and Adolph Rupp; fourth in Final Fours (9) behind only Wooden\, Krzyzewski and Dean Smith; second in NCAA Tournament wins (76) and games (100); second in NCAA Tournament history in No. 1 seeds (12); third in NCAA Tournament winning percentage (.760) among coaches with at least 50 games; first to win three national championships at his alma mater; eighth all-time in Division I wins (816) and reached 800 wins in fewer seasons and the second-fewest games in NCAA history; and sixth all-time in career winning percentage (.791) URL:https://www.med.unc.edu/medicine/event/nov-9/ LOCATION:NC CATEGORIES:Medicine Grand Rounds ATTACH;FMTTYPE=image/jpeg:https://www.med.unc.edu/medicine/wp-content/uploads/sites/945/2018/12/roy-williams.jpeg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20171114T140000 DTEND;TZID=America/New_York:20171114T150000 DTSTAMP:20260414T170507 CREATED:20171114T190000Z LAST-MODIFIED:20190307T185805Z UID:10000833-1510668000-1510671600@www.med.unc.edu SUMMARY:McAllister Heart Institute Seminar Series: Jeffery Holmes\, MD\, PhD\, Scar Formation after Myocardial Infarction DESCRIPTION:Speaker: Jeff Holmes\, M.D.\, Ph.D.Professor of Biomedical Engineering & Medicine\, University of VirginiaTopic: Scar Formation After Myocardial Infarction: What Happens\, Why does it Matter\, and What Can We Do about It?” URL:https://www.med.unc.edu/medicine/event/mcallister-heart-institute-seminar-series-jeffery-holmes-md-phd-1/ LOCATION:NC CATEGORIES:Medicine Grand Rounds END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20171116T120000 DTEND;TZID=America/New_York:20171116T130000 DTSTAMP:20260414T170507 CREATED:20171116T170000Z LAST-MODIFIED:20190307T185803Z UID:10000835-1510833600-1510837200@www.med.unc.edu SUMMARY:Medicine Grand Rounds\, Stacy Wood "Medicine + Marketing: The New Role of Consumer Theory in Patient-Centric Care" DESCRIPTION:As the healthcare environment changes\, patients increasingly see more personal control in their choice of doctors\, therapies\, and systems of care. From new models of tele-health to the ubiquitous direct-to-consumer pharmaceutical ads on TV\, patients are shifting to a “customer mind-set” when they make health decisions and this has sweeping ramifications for healthcare providers. \nIn this lecture\, internationally-recognized scholar in consumer theory and President-Elect of the Association for Consumer Research\, Dr. Stacy Wood (the Langdon Distinguished University Professor of Marketing and Executive Director of the Consumer Innovation Collaborative\, NC State University) will give a practical introduction into how consumer theory can be used by medical practitioners to improve patient choice environments\, patient adherence\, and patient satisfaction. Based on her research with physicians\, she will discuss common pitfalls to avoid and exciting new arenas that combine the best of medicine with the best of marketing to promote patient well-being. URL:https://www.med.unc.edu/medicine/event/nov-16/ LOCATION:NC CATEGORIES:Medicine Grand Rounds ATTACH;FMTTYPE=image/jpeg:https://www.med.unc.edu/medicine/wp-content/uploads/sites/945/2018/12/stacy-wood.jpeg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20171121T140000 DTEND;TZID=America/New_York:20171121T150000 DTSTAMP:20260414T170507 CREATED:20171121T190000Z LAST-MODIFIED:20190307T185801Z UID:10000837-1511272800-1511276400@www.med.unc.edu SUMMARY:McAllister Heart Institute Seminar Series: Francis Miller\, MD\, Role of Smooth Muscle Cell NADPH Oxidase in Vascular Disease DESCRIPTION:Speaker: Francis J. Miller\, MD\, Professor of Medicine\, Dept. of Internal Medicine\, Division of Cardiology\, Duke University School of MedicineTopic: Role of Smooth Muscle Cell NADPH Oxidase in Vascular Disease \nInformation from Dr. Miller on his lecture:The primary goal of my research program is to understand the molecular and cellular mechanisms that contribute to the generation of reactive oxygen species and pathophysiology of vascular disease. The objectives of my seminar are:1) Describe the role of inflammation and oxidative stress in the development of vascular disease.2) Describe the structure and function of the vascular NADPH oxidases in the blood vessel.3) Discuss the role of phosphorylation and endocytosis in activation of the Nox1 NAPDH oxidase.4) Discuss the regulation of Nox4 NADPH oxidase by miRNA and its role in smooth muscle cell differentiation.Describe novel approaches for targeting smooth muscle cell Nox1 in vascular disease. URL:https://www.med.unc.edu/medicine/event/mcallister-heart-institute-seminar-series-jeffery-holmes-md-phd/ LOCATION:NC CATEGORIES:Medicine Grand Rounds END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20171130T120000 DTEND;TZID=America/New_York:20171130T130000 DTSTAMP:20260414T170507 CREATED:20171130T170000Z LAST-MODIFIED:20190307T185759Z UID:10000839-1512043200-1512046800@www.med.unc.edu SUMMARY:Medicine Grand Rounds\, Joseph Rossi and William Powers\, "PFO Closure to Reduce Stroke Risk -- How Compelling Is the Evidence?" DESCRIPTION:Recent clinical trials have investigated the efficacy of mechanical closure of patent foramen ovale (PFO) for prevention of recurrent stroke. We will review the epidemiological evidence linking PFO and stroke\, the methodology and results of clinical trials of secondary stroke prevention in patients with PFO\, and the techniques for mechanical closure of PFO. \nWilliam J. Powers\, MD\, is an expert on cerebral blood flow and metabolism\, as well as stroke treatment and prevention. Powers has dedicated his career to improving the outcome of patients with stroke and cerebrovascular disease. His early work helped establish concepts of blood pressure auto-regulation and acute blood pressure management in stroke\, influential on the choice and timing of anti-hypertensive therapies and the consideration of acute vs. chronic blood pressure control. He later identified patterns of blood pressure control in intracerebral hemorrhage and noted that the tissue surrounding the hemorrhage is not ischemic. Powers spearheaded studies suggesting chronic hemodynamic impairment from occlusive cerebrovascular disease. He is the H. Houston Merritt Distinguished Professor and chair of the Department of Neurology. \nJoseph Rossi\, MD\, MSCI\, FACC\, FSCAI\, is director of the Cardiac Catheterization Lab and Program Director of the Interventional Cardiology Fellowship. He specializes in interventional cardiology. URL:https://www.med.unc.edu/medicine/event/nov-30/ LOCATION:NC CATEGORIES:Medicine Grand Rounds ATTACH;FMTTYPE=image/jpeg:https://www.med.unc.edu/medicine/wp-content/uploads/sites/945/2018/12/william-powers.jpeg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20171204T120000 DTEND;TZID=America/New_York:20171204T130000 DTSTAMP:20260414T170507 CREATED:20171204T170000Z LAST-MODIFIED:20190307T185757Z UID:10000840-1512388800-1512392400@www.med.unc.edu SUMMARY:Cardiovascular Grand Rounds: Dr. Chaitanya Madamanchi\, Myocardial Strain Imaging DESCRIPTION:Speaker: Chaitanya Madamanchi\, MD\, UNC Cardiology FellowTopic: Myocardial Strain Imaging URL:https://www.med.unc.edu/medicine/event/cardiovascular-grand-rounds-dr-chaitanya-madamanchi/ LOCATION:NC CATEGORIES:Medicine Grand Rounds END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20171205T140000 DTEND;TZID=America/New_York:20171205T150000 DTSTAMP:20260414T170507 CREATED:20171205T190000Z LAST-MODIFIED:20190307T185754Z UID:10000842-1512482400-1512486000@www.med.unc.edu SUMMARY:McAllister Heart Institute Seminar Series: Kristina I. Boström\, MD\, PhD DESCRIPTION: URL:https://www.med.unc.edu/medicine/event/mcallister-heart-institute-seminar-series-kristina-i-bostrom-md-phd/ LOCATION:NC CATEGORIES:Medicine Grand Rounds END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20171207T120000 DTEND;TZID=America/New_York:20171207T130000 DTSTAMP:20260414T170507 CREATED:20171207T170000Z LAST-MODIFIED:20190307T185752Z UID:10000844-1512648000-1512651600@www.med.unc.edu SUMMARY:Medicine Grand Rounds\, Eric Klett\, "Dietary Fat -- Impact on the Development of Chronic Metabolic Diseases" DESCRIPTION:Consumption of dietary fat has been the focus of debate for more than 50 years. Ancel Keys’ diet-heart hypothesis changed the way Americans eat and as a result has left us with significant unintended consequences. Dr. Klett will review the history of the diet-heart hypothesis\, the recently discovered unpublished data refuting the diet-heart hypothesis\, and how changes in the type of dietary fatty acids consumed might be contributing to the development of diabetes. \nEric Klett practices General Endocrinology with clinical interests in thyroid disease\, lipid disorders and transgender medicine. He is Assistant Professor of Medicine and Nutrition and serves as the Associate Endocrinology Fellowship Director. URL:https://www.med.unc.edu/medicine/event/dec-7/ LOCATION:NC CATEGORIES:Medicine Grand Rounds ATTACH;FMTTYPE=image/jpeg:https://www.med.unc.edu/medicine/wp-content/uploads/sites/945/2018/12/eric-klett-1.jpeg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20171211T120000 DTEND;TZID=America/New_York:20171211T130000 DTSTAMP:20260414T170507 CREATED:20170918T194500Z LAST-MODIFIED:20190307T185749Z UID:10000923-1512993600-1512997200@www.med.unc.edu SUMMARY:McAllister Heart Institute Seminar Series: Kristy Red-Horse\, PhD. Coronary Artery Development DESCRIPTION:Speaker: Kristy Red-Horse\, PhD\, Assistant Professor\, Department of Biology\, Stanford UniversityTopic: Coronary Artery Development: Transcriptional Regulation of Blood Flow Guided Behaviors URL:https://www.med.unc.edu/medicine/event/mcallister-heart-institute-seminar-series-kristy-red-horse-phd/ LOCATION:NC CATEGORIES:Medicine Grand Rounds END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20171214T120000 DTEND;TZID=America/New_York:20171214T130000 DTSTAMP:20260414T170507 CREATED:20171214T170000Z LAST-MODIFIED:20190307T185639Z UID:10000846-1513252800-1513256400@www.med.unc.edu SUMMARY:Medicine Grand Rounds\, Rumey Ishizawar "Autoimmunity Induced by Cancer Immunotherapy" DESCRIPTION:Immune-related adverse events are an unintentional side effect of immune checkpoint inhibitors used for cancer immunotherapy. Immune checkpoint inhibitors upregulate the immune system to prevent tumor evasion and promote destruction of tumor cells. These immune checkpoint inhibitors are effective as noted by the expanding number of FDA-approved drugs in this class and number of indications. In upregulating the immune system to target tumor cells\, these immune checkpoint inhibitors can tip the balance of the immune system to overreact against normal cells\, leading to presentations similar to autoimmune diseases. Emergence of immune-related adverse events can provide insight to rare autoimmune diseases. \nRumey Ishizawar is an assistant professor of Medicine and the medical director of the Rheumatology Specialty Clinic. She is developing an autoimmunity database\, studying oncology patients that develop immune-related adverse events. The immune-oncology patient registry will promote clinical\, translational and basic research. URL:https://www.med.unc.edu/medicine/event/dec-14/ LOCATION:NC CATEGORIES:Medicine Grand Rounds ATTACH;FMTTYPE=image/jpeg:https://www.med.unc.edu/medicine/wp-content/uploads/sites/945/2018/12/rumey-ishizawar.jpeg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20180104T120000 DTEND;TZID=America/New_York:20180104T130000 DTSTAMP:20260414T170507 CREATED:20180104T170000Z LAST-MODIFIED:20190307T185354Z UID:10000848-1515067200-1515070800@www.med.unc.edu SUMMARY:Medicine Grand Rounds Cancelled Due to Adverse Weather DESCRIPTION: URL:https://www.med.unc.edu/medicine/event/jan-4/ LOCATION:NC CATEGORIES:Medicine Grand Rounds END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20180109T140000 DTEND;TZID=America/New_York:20180109T150000 DTSTAMP:20260414T170507 CREATED:20180109T190000Z LAST-MODIFIED:20190307T185352Z UID:10000946-1515506400-1515510000@www.med.unc.edu SUMMARY:McAllister Heart Institute Seminar Series: Nenad Bursac\, PhD\, “Engineering Excitable Tissues for Experimental Studies and Regenerative Therapy” DESCRIPTION:Speaker: Nenad Bursac\, PhD\, Professor of Biomedical Engineering\, Duke UniversityTopic: Engineering Excitable Tissues for Experimental Studies and Regenerative Therapy \nPresentation Preview: In this talk\, I will present our recent progress on engineering of human excitable tissues using primary\, stem cell-derived\, and genetically engineered cell sources. I will first describe scalable methodology for engineering of functional human cardiac tissues for use in medium-throughput in vitro studies and treatment of cardiac injury. Then I will describe how building on our work with rat cells\, we for the first time engineered electrically and chemically responsive\, contractile human skeletal muscle tissues made of primary cells isolated from standard muscle biopsies and induced pluripotent stem cells. Finally\, I will describe methods to convert human unexcitable fibroblasts into an autonomous source of electrically excitable and actively conducting cells using forced expression of prokaryotic and mammalian ion channels. Together\, these results open doors to new studies of human excitable tissue function\, disease\, and regeneration\, and provide preclinical assays for testing of novel therapeutics. URL:https://www.med.unc.edu/medicine/event/copy3_of_mcallister-heart-institute-seminar-series-hossein-ardehali-md-phd-role-of-iron-in-cardiovascular-disease/ LOCATION:NC CATEGORIES:Medicine Grand Rounds END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20180111T120000 DTEND;TZID=America/New_York:20180111T130000 DTSTAMP:20260414T170507 CREATED:20180111T170000Z LAST-MODIFIED:20190307T185350Z UID:10000950-1515672000-1515675600@www.med.unc.edu SUMMARY:Medicine Grand Rounds\, Balfour Sartor and Edward Barnes\, "Post-Operative Crohn’s Disease: Current and Future Management" DESCRIPTION:Rescheduled from January 4 — In this lecture\, Drs. Sartor and Barnes will summarize an evidence-based approach to the management of post-operative Crohn’s disease\, and describe the future landscape based on novel molecular and microbial predictors of risk of recurrence. This topic is clinically important because the majority of patients with Crohn’s disease eventually undergo surgical resection for refractory disease or complications (obstruction or abscess/fistulae)\, and experience recurrent disease after resection. There are important advances in the field\, but the goal of preventing recurrence after surgery has not yet been achieved; this goal will require innovative approaches. \nBalfour Sartor is a gastroenterologist and mucosal immunologist with a long-standing interest in mechanisms by which commensal microbiota induce chronic intestinal inflammation vs. mucosal homeostasis. He specializes in inflammatory bowel diseases (IBD) and co-directs the UNC Multidisciplinary IBD Center. \nEdward Barnes is assistant professor of Medicine in the Division of Gastroenterology and Hepatology. Dr. Barnes’ interests include evaluation of clinical outcomes related to differing treatment strategies among patients with Inflammatory Bowel Disease\, as well as the effects that these strategies have on cost and resource utilization. URL:https://www.med.unc.edu/medicine/event/jan-11/ LOCATION:NC CATEGORIES:Medicine Grand Rounds ATTACH;FMTTYPE=image/jpeg:https://www.med.unc.edu/medicine/wp-content/uploads/sites/945/2018/12/balfour-sartor.jpeg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20180118T120000 DTEND;TZID=America/New_York:20180118T130000 DTSTAMP:20260414T170507 CREATED:20180118T170000Z LAST-MODIFIED:20190307T185348Z UID:10000953-1516276800-1516280400@www.med.unc.edu SUMMARY:Medicine Grand Rounds Cancelled Due to Adverse Weather DESCRIPTION: URL:https://www.med.unc.edu/medicine/event/jan-18/ LOCATION:NC CATEGORIES:Medicine Grand Rounds END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20180118T140000 DTEND;TZID=America/New_York:20180118T150000 DTSTAMP:20260414T170507 CREATED:20180118T190000Z LAST-MODIFIED:20190307T185346Z UID:10000954-1516284000-1516287600@www.med.unc.edu SUMMARY:McAllister Heart Institute Seminar Series: Didier Stainier\, PhD\, “Cardiovascular development and regeneration in zebrafish” DESCRIPTION:Speaker: Didier Stainier\, PhD\, Director of the Max Planck Institute for Heart & Lung Research in Bad Nauheim\, GermanyTopic: Cardiovascular development and regeneration in zebrafish URL:https://www.med.unc.edu/medicine/event/copy2_of_mcallister-heart-institute-seminar-series-hossein-ardehali-md-phd-role-of-iron-in-cardiovascular-disease/ LOCATION:NC CATEGORIES:Medicine Grand Rounds END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20180123T140000 DTEND;TZID=America/New_York:20180123T150000 DTSTAMP:20260414T170507 CREATED:20180123T190000Z LAST-MODIFIED:20190307T185344Z UID:10000955-1516716000-1516719600@www.med.unc.edu SUMMARY:McAllister Heart Institute Seminar Series: Wolfgang Bergmeier\, PhD\, “Platelets at the vascular interface: finding the right balance between too little and too much activation” DESCRIPTION:Speaker: Wolfgang Bergmeier\, PhD\, Associate Professor of Biochemistry & Biophysics\, UNCTopic: Platelets at the vascular interface: finding the right balance between too little and too much activation \nPresentation Preview: Platelets are small anucleated cells that constantly patrol the cardiovascular system to preserve its integrity and prevent excessive blood loss where the vessel lining is breached. Their key challenge is to form a hemostatic plug under conditions of high shear forces. To do so\, platelets have evolved a molecular machinery that enables them to sense trace amounts of signals at the site of damage and to rapidly shift from a non-adhesive to a pro-adhesive state. However\, this highly efficient molecular machinery can also lead to unintended platelet activation and cause clinical complications such as thrombocytopenia and thrombosis. Thus\, several checkpoints are in place to tightly control platelet activation and adhesiveness in space and time. In this talk I will discuss the major molecular mechanisms controlling platelet activation in circulation and at sites of vascular injury\, with a particular focus on signaling by the small GTPase Rap1. URL:https://www.med.unc.edu/medicine/event/copy_of_mcallister-heart-institute-seminar-series-hossein-ardehali-md-phd-role-of-iron-in-cardiovascular-disease/ LOCATION:NC CATEGORIES:Medicine Grand Rounds END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20180125T120000 DTEND;TZID=America/New_York:20180125T130000 DTSTAMP:20260414T170507 CREATED:20180125T170000Z LAST-MODIFIED:20190307T185341Z UID:10000956-1516881600-1516885200@www.med.unc.edu SUMMARY:Medicine Grand Rounds\, Amy Shaheen "Quality Improvement -- Value of Learners in a Clinic Setting" DESCRIPTION:The LCME and ACGME require that learners participate and demonstrate competency in quality improvement activities. However\, learners are not always welcome to do these activities in clinical settings due to perceived burdens on productivity\, time\, and resources. Dr. Shaeen will demonstrate the learner activities as beneficial to the practice and health system. \nAmy W. Shaheen is an Associate Professor of Medicine in the Division of General Medicine and Clinical Epidemiology. Her clinical expertise is in general internal medicine\, and quality improvement in the care of people with acute and chronic illness. She is co-director of the Community Based Longitudinal Care Course that places medical students in primary care practices. She helps design the curriculum around primary care\, quality and safety\, and end of life issues. She also works as subject matter expert\, developing tools to improve the care of patients with COPD. URL:https://www.med.unc.edu/medicine/event/jan-25/ LOCATION:NC CATEGORIES:Medicine Grand Rounds ATTACH;FMTTYPE=image/jpeg:https://www.med.unc.edu/medicine/wp-content/uploads/sites/945/2018/12/amy-shaheen.jpeg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20180129T120000 DTEND;TZID=America/New_York:20180129T130000 DTSTAMP:20260414T170507 CREATED:20180129T170000Z LAST-MODIFIED:20190307T185339Z UID:10000957-1517227200-1517230800@www.med.unc.edu SUMMARY:Cardiovascular Grand Rounds: Dr. Shivanshu Madan\, Cardiac MRI in the Modern Era DESCRIPTION:Speaker: Shivanshu Madan\, MD\, UNC Cardiology FellowTopic: Cardiac MRI in the Modern Era URL:https://www.med.unc.edu/medicine/event/cardiovascular-grand-rounds-dr-shivanshu-madan/ LOCATION:NC CATEGORIES:Medicine Grand Rounds END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20180130T140000 DTEND;TZID=America/New_York:20180130T150000 DTSTAMP:20260414T170507 CREATED:20180130T190000Z LAST-MODIFIED:20190307T185337Z UID:10000958-1517320800-1517324400@www.med.unc.edu SUMMARY:McAllister Heart Institute Seminar Series: Hossein Ardehali\, MD\, PhD\, "Role of Iron in Cardiovascular Disease" DESCRIPTION:Speaker: Hossein Ardehali\, MD\, PhD\, Director of the Center for Molecular Cardiology & the Medical Scientists Program at Northwestern UniversityTopic: Role of Iron in Cardiovascular Disease URL:https://www.med.unc.edu/medicine/event/mcallister-heart-institute-seminar-series-hossein-ardehali-md-phd-role-of-iron-in-cardiovascular-disease/ LOCATION:NC CATEGORIES:Medicine Grand Rounds END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20180201T120000 DTEND;TZID=America/New_York:20180201T130000 DTSTAMP:20260414T170507 CREATED:20180201T170000Z LAST-MODIFIED:20190325T143306Z UID:10000959-1517486400-1517490000@www.med.unc.edu SUMMARY:Medicine Grand Rounds\, Eric Juengst and Greg Copenhaver\, "The Biology and Ethics of CRISPR" DESCRIPTION:CRISPR technology is a simple yet powerful tool for editing genomes. It allows researchers to easily alter DNA sequences and modify gene function. Its many potential applications include correcting genetic defects\, treating and preventing the spread of diseases and improving crops. However\, its promise also raises ethical concerns. Drs. Juengst and Copenhaver will explore the biological basis of CRISPR technology and its potential biomedical applications. \nEric Juengst is Professor in the Department of Social Medicine and the Department of Genetics. He also serves as Director of the UNC Center for Bioethics. Dr. Juengst’s research interests and publications have focused on the conceptual and ethical issues raised by new advances in human genetics and biotechnology. Since 1997 he has been the principal investigator of a series of N.I.H. funded research projects examining the ethical and social policy issues that will be raised by the availability of genetic and genomic technologies. His current R01 project examines ethical and social implications of “Personalized Genomic Medicine”as a paradigm for health care. \nGreg Copenhaver is a professor in the UNC Biology Department. He serves as the Director of Graduate Studies (Biology – MCDB) at UNC and as Editor-in-Chief for the peer-reviewed scientific journal PLoS Genetics. In addition\, he co-founded the biotechnology company Chromatin Inc. He has also authored or co-authored numerous research papers including publications in Science\, Nature\, PLoS Genetics\, eLife\, Proceedings of the National Academy of Sciences\, and Nature Genetics. URL:https://www.med.unc.edu/medicine/event/feb-1/ LOCATION:NC CATEGORIES:Medicine Grand Rounds ATTACH;FMTTYPE=image/jpeg:https://www.med.unc.edu/medicine/wp-content/uploads/sites/945/2018/12/eric-juengst.jpeg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20180206T140000 DTEND;TZID=America/New_York:20180206T150000 DTSTAMP:20260414T170507 CREATED:20180206T190000Z LAST-MODIFIED:20190307T185333Z UID:10000960-1517925600-1517929200@www.med.unc.edu SUMMARY:McAllister Heart Institute Seminar Series: Brian Jensen\, MD\, Novel roles for the nuclear receptor ROR-alpha in regulating cardiac hypertrophy DESCRIPTION:Speaker: Brian Jensen\, MD\, Associate Professor of Medicine & Pharmacology\, UNCTopic: Novel roles for the nuclear receptor ROR-alpha in regulating cardiac hypertrophy URL:https://www.med.unc.edu/medicine/event/mcallister-heart-institute-seminar-series-brian-jensen-md-novel-roles-for-the-nuclear-receptor-ror-alpha-in-regulating-cardiac-hypertrophy/ LOCATION:NC CATEGORIES:Medicine Grand Rounds END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20180208T120000 DTEND;TZID=America/New_York:20180208T130000 DTSTAMP:20260414T170507 CREATED:20180208T170000Z LAST-MODIFIED:20190307T185331Z UID:10000961-1518091200-1518094800@www.med.unc.edu SUMMARY:Medicine Grand Rounds\, Matthew Cavender "Coronary Artery Disease in Patients with Diabetes Mellitus" DESCRIPTION:Diabetes mellitus is a common medical problem and a significant risk factor for the development of atherosclerotic coronary artery disease. Coronary artery disease is highly prevalent and is the major cause of morbidity and mortality in diabetic patients. Dr. Cavender will discuss the link between diabetes and heart disease\, strategies to reduce cardiovascular risk in this population\, and insights from observational data on the effectiveness of therapies. \nDr. Cavender is an active interventional cardiologist with a focus on catheter-based interventions for coronary artery disease\, aortic and mitral valve disease\, peripheral vascular disease\, and cardiogenic shock. In addition to his clinical interests\, he has an active research program with an emphasis on improving the quality of health care delivery and understanding the clinical effectiveness of pharmacological and device based therapies for patients with coronary artery disease\, diabetes\, peripheral arterial disease\, and valvular heart disease. \nIn 2017\, he was selected by Cardiology Today as one of its Next Gen Innovators\, “a bright group of early career cardiologists identified as innovators in the field.” Dr. Cavender joined UNC’s interventional cardiology team in 2016\, and since then has been a valued faculty member\, performing procedures\, seeing patients in clinic\, and pursuing a research program. URL:https://www.med.unc.edu/medicine/event/feb-8/ LOCATION:NC CATEGORIES:Medicine Grand Rounds ATTACH;FMTTYPE=image/jpeg:https://www.med.unc.edu/medicine/wp-content/uploads/sites/945/2018/12/matthew-cavender.jpeg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20180212T120000 DTEND;TZID=America/New_York:20180212T130000 DTSTAMP:20260414T170507 CREATED:20180212T170000Z LAST-MODIFIED:20190307T185328Z UID:10000962-1518436800-1518440400@www.med.unc.edu SUMMARY:Cardiovascular Grand Rounds: Dr. Gregory Means\, Drug Eluting Balloon Technology: History\, Pharmacokinetics\, Current & Future Use DESCRIPTION:Speaker: Gregory Means\, MD\, UNC Cardiology FellowTopic: Drug Eluting Balloon Technology: History\, Pharmacokinetics\, Current & Future Use URL:https://www.med.unc.edu/medicine/event/cardiovascular-grand-rounds-dr-gregory-means/ LOCATION:NC CATEGORIES:Medicine Grand Rounds END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20180213T140000 DTEND;TZID=America/New_York:20180213T150000 DTSTAMP:20260414T170507 CREATED:20180213T190000Z LAST-MODIFIED:20190307T185326Z UID:10000963-1518530400-1518534000@www.med.unc.edu SUMMARY:McAllister Heart Institute Seminar Series: Christopher L. Holley\, MD\, PhD. Non-coding RNA\, RNA modifications\, and Oxidative Stress in the Heart DESCRIPTION:Speaker: Christopher L. Holley\, MD\, PhD\, Assistant Professor of Medicine\, Department of Cardiology\, Duke UniversityTopic: Non-coding RNA\, RNA modifications\, and Oxidative Stress in the Heart URL:https://www.med.unc.edu/medicine/event/mcallister-heart-institute-seminar-series-christopher-l-holley-md-phd-non-coding-rna-rna-modifications-and-oxidative-stress-in-the-heart/ LOCATION:NC CATEGORIES:Medicine Grand Rounds END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20180215T120000 DTEND;TZID=America/New_York:20180215T130000 DTSTAMP:20260414T170507 CREATED:20180215T170000Z LAST-MODIFIED:20240208T125859Z UID:10000964-1518696000-1518699600@www.med.unc.edu SUMMARY:Lydia Chang and Arun Kannappan\, "Sepsis Management: Beyond the Bundle" DESCRIPTION:Sepsis remains a life-threatening disease in the setting of infection that causes significant morbidity and mortality. The new Sepsis Definitions and updated Surviving Sepsis Guidelines released in the past two years herald a time of change in the assessment and treatment of sepsis. This lecture aims to address many questions that remain unanswered in treating this illness by reviewing the latest information on epidemiology in the age of sepsis bundle implementation\, methods to predict fluid responsiveness in patients with sepsis and hypotension\, as well as new diagnostics and therapies recently approved and on the horizon. \nLydia Chang is Assistant Professor of Medicine in the division of Pulmonary Diseases and Critical Care Medicine. She specializes in critical care medicine\, respiratory failure\, ARDS\, sepsis\, medical emergency teams\, asthma\, and COPD. \n \nArun Kannappan is Chief Fellow\, Pulmonology and Critical Care. His interests include ICU outcomes\, quality improvement\, and academic education. URL:https://www.med.unc.edu/medicine/event/feb-15/ LOCATION:NC CATEGORIES:Medicine Grand Rounds ATTACH;FMTTYPE=image/jpeg:https://www.med.unc.edu/medicine/wp-content/uploads/sites/945/2018/12/lydia-chang.jpeg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20180217T080000 DTEND;TZID=America/New_York:20180217T160000 DTSTAMP:20260414T170507 CREATED:20180217T130000Z LAST-MODIFIED:20190307T185322Z UID:10000965-1518854400-1518883200@www.med.unc.edu SUMMARY:4th Annual Women's Heart Symposium DESCRIPTION:Register by February 5! Call Barbara at 919-843-5205 or email breid@med.unc.edu with first & last name\, contact number\, & t-shirt size (S\, M\, L\, XL). Lunch will be provided. \nTOPICS AT THE SYMPOSIUM INCLUDE• An overview of heart disease in women• Heart failure in women• Device therapy in women: cardiac electrophysiology\, pacemakers\, defibrillators\, and more• Cardiovascular disease and exercise• Cardiovascular disease and nutrition• Cardiovascular disease and stress• Stretching for Health \nHosted by Paula Miller\, MD\, Clinical Associate Professor\, Medical Director of Cardiac Rehabilitation\, and Director of the Women’s Heart Program at UNC School of Medicine. She will be hosting the event and giving an overview of heart disease in women. URL:https://www.med.unc.edu/medicine/event/4th-annual-womens-heart-symposium/ LOCATION:NC CATEGORIES:Medicine Grand Rounds END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20180220T140000 DTEND;TZID=America/New_York:20180220T150000 DTSTAMP:20260414T170507 CREATED:20180220T190000Z LAST-MODIFIED:20190307T185320Z UID:10000966-1519135200-1519138800@www.med.unc.edu SUMMARY:McAllister Heart Institute Seminar Series: Deepak Voora\, MD\, “Genotype-informed Statin Therapy” DESCRIPTION:Speaker: Dr. Deepak Voora\, MD\, Associate Professor of Medicine\, Department of Cardiology\, Center for Applied Genomics and Precision Medicine at Duke University Topic: “Genotype-informed Statin Therapy” \nSeminar Synopsis: Statins are among the most commonly prescribed medications to lower cholesterol and to prevent cardiovascular disease. Although well tolerated by most patients\, a significant proportion of patients develop musculoskeletal symptoms associated with statin therapy that can lead to premature statin discontinuation\, elevated cholesterol\, and increased risk for cardiovascular events. Our group was among the first to discover a reduced function genetic variant in the SLCO1B1 gene that predisposes to higher statin concentrations and statin-associated musculoskeletal symptoms (SAMS). We have extended this finding to higher cholesterol levels in patients with cardiovascular disease treated with statins and tested for effects on cardiovascular events. The statin-specific nature of SLCO1B1 associations with SAMS that we and others have identified laid the foundation to translate our findings into the clinic. We have developed a genotype-informed statin therapy (GIST) intervention based on communicating SLCO1B1 genotype based risk for SAMS and tailored prescriptions to reduce the risk of SAMS. In two prospective studies\, including a randomized clinical trial\, GIST improves perceptions of statin therapy\, increased statin re-initiation\, and lowered cholesterol levels in patients with statin-intolerance. URL:https://www.med.unc.edu/medicine/event/mcallister-heart-institute-seminar-series-dr-deepak-voora-md-201cgenotype-informed-statin-therapy201d/ LOCATION:NC CATEGORIES:Medicine Grand Rounds END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20180222T120000 DTEND;TZID=America/New_York:20180222T130000 DTSTAMP:20260414T170507 CREATED:20180222T170000Z LAST-MODIFIED:20190307T185318Z UID:10000967-1519300800-1519304400@www.med.unc.edu SUMMARY:Medicine Grand Rounds\, Nancy Allbritton "Organs-on-Chips" DESCRIPTION:Organ-on-chips are miniaturized devices that arrange living cells to simulate functional subunits of tissues and organs. These microdevices provide exquisite control of tissue microenviroment for the investigation of organ-level physiology and disease. Human organ-on-chips are expected to transform biomedical research providing platforms that accurately replicate human tissues\, enable a better understanding of human-to-human physiologic variations and even permit patient-specific organ mimics. These human organ facsimiles will fundamentally alter drug discovery and development by providing human constructs for screening assays\, toxicity measurements and investigation of molecular-level drug actions. \nNancy L. Allbritton is the Kenan Professor and Chair of the Joint Department of Biomedical Engineering at UNC and NC State\, and Kenan Professor in the UNC Department of Chemistry. Her research focuses on the development of novel technologies for applications in single-cell analysis\, micro-arrays and fluidics\, and organ-on-chip. It has resulted in over 180 full-length journal publications and patents and led to 15 commercial products. Her research program has been well funded by the National Institutes of Health with nearly $60 million in grants since 1994. URL:https://www.med.unc.edu/medicine/event/feb-22/ LOCATION:NC CATEGORIES:Medicine Grand Rounds ATTACH;FMTTYPE=image/jpeg:https://www.med.unc.edu/medicine/wp-content/uploads/sites/945/2018/12/nancy-allbritton.jpeg END:VEVENT END:VCALENDAR