Board of Advisors Meeting
2016-08-03 10:30 - 14:00 (America/New_York) | NC

Writing Committee Meeting
2016-08-16 09:30 - 10:30, 2016-09-13 09:30 - 10:30

Medicine Grand Rounds - Dr. Christopher Klipstein
2016-09-08 12:00 - 13:00
“On Lecturing: Tips on Delivering an Effective Lecture”

Journal Club
2016-09-14 13:30 - 14:30

Medicine Grand Rounds - Dr. Gregg Silverman: "Rheumatoid Arthritis: From Genes to Joints"
2016-09-15 12:00 - 13:00
Dr. Gregg Silverman, NYU Professor of Medicine and Pathology and Co-Director of the Muskuloskeletal Center of Excellence, will discuss the pathogenesis of rheumatoid arthritis, incorporating environmental factors, genetic pre-dispositions, and the development of a diverse group of autoantibodies, paying particular focus on anti-citrullinated protein antibodies (ACPAs) and the role of B and T-cell activation in breaching immunologic tolerance.

Grand Rounds: Mel Scheinman, MD
2016-09-22 12:00 - 13:00
Speaker: Mel Scheinman, MD, Professor of Medicine, Walter H. Shorenstein Endowed Chair in Cardiology, University of California
Topic: “ECG Signs Denoting Risk for Sudden Death”

Medicine Grand Rounds: David J. Weber, Matthew Collins and Helen M. Lazear "Zika Virus Infection"
2016-09-22 12:00 - 13:00
Researchers at UNC School of Medicine and UNC Hospitals are leading the charge in Zika research with more than 10 groups currently studying Zika – its transmission, its epidemiology and its associated neurological and birth defects, including microcephaly.
Dr. David Weber is a member of UNC Hospitals’ Zika Response Working Group, keeping clinic directors informed of Zika virus updates, providing UNC Health Care personnel and patients with pre- and post-travel counseling and evaluations, and developing a diagnostic testing algorithm. Weber’s research focuses on hospital-acquired infections, especially antibiotic-resistant pathogens and outbreak investigations.
Dr. Matthew Collins and his colleagues are trying to develop improved serodiagnostics to precisely define Zika virus exposure in those living in or traveling to endemic areas. Collins is also working with collaborators in UNC departments of obstetrics and gynecology, epidemiology, and family medicine, as well as colleagues in Leόn, Nicaragua, to define the epidemiology of Zika virus as it emerges in Nicaragua.
The Lazear lab is investigating the protective role of skin-specific antiviral effects of IFN-λ and is also identifying host factors that restrict vertebrate-specific flavivirus infection in mosquito cells. Dr. Helen Lazear’s lab also has developed a novel mouse model for studying Zika virus pathogenesis.

Medicine Grand Rounds, Alex Duncan "Inflammasomes in Infection and Inflammatory Disease: What Can Go Wrong with Host Defense"
2016-09-29 12:00 - 13:00
Dr. Duncan is an infectious diseases specialist and physician scientist. He runs a laboratory focused on understanding the role of the human immune system both in protecting us from infection but also in understanding how host immunity is exploited by pathogens to promote infections. His lab studies host immune response to N. gonorrhoeae and S. aureus, which are both recognized by the CDC as top public health threats in emerging antimicrobial resistance. Dr. Duncan will share why walking into his lab to analyze new data never gets old and how bench side research leads to better patient care.

Grand Rounds: Olivia Gilbert, MD
2016-10-03 12:00 - 13:00
Speaker: Olivia Gilbert, MD. Advanced Heart Failure & Transplant Cardiology Fellow, University of North Carolina.Topic: “Evolution of the LVAD”

McAllister Heart Institute Seminar Series: Frank Conlon, Ph.D
2016-10-04 11:00 - 12:00
Speaker: Frank Conlon, Ph.D, Professor, Biology—UNC
Topic: “Proteomic Based Approaches to Cardiac Development and Disease”

Medicine Grand Rounds, Samantha Meltzer-Brody & Amy Weil "An Institutional Program to Increase Physician Engagement"
2016-10-06 12:00 - 13:00
Awareness, Assessment and Treatment of Burnout

Medicine is facing an era of rapid and continuous change in nearly every way. The profession of medicine also is approaching an epidemic of physician burnout — a complex and systemic issue that is receiving increased attention from both within and outside the field of healthcare. Novel and systemic approaches are needed that directly address the drivers of physician burnout and add wellness as a critical metric to the collective performance of healthcare institutions.
Dr. Samantha Meltzer-Brody, associate professor of psychiatry, will explain the new UNC School of Medicine initiative that adopts the Quadruple aim. She also will detail the specific components of this comprehensive, institution-wide program that seeks to increase physician engagement and application to the Department of Internal Medicine.
As national conversations about physician burnout continue to grow louder, Meltzer-Brody knows there’s not a simple solution to the problem. “Addressing physician burnout requires a dialogue that is both bottom-up and top-down,” said Meltzer-Brody. “This takes an all-hands-on-deck effort.”
Building Resilience: Current and Future Wellness Programming, Emerging Directions for Structural Change
Amy Weil is Co-Leader of the UNC Wellness Committee, and Co-Advisor of the Larry J. Keith Advising Colleges. Her presentation will introduce a new wellness program. “When you enter the medical field, whether as a student or a resident, you’re often optimistic about the profession,” says Weil. “But external forces too often cause that optimism to deteriorate. The forces in our health care system today threaten to prevent us from having the kind of relationships with patients that allow us to feel fulfilled as physicians. Humanities, in combination with things like mindfulness and other activities that foster well-being, can help us remain present when we’re with our patients and prevent those outside pressures from intruding on these relationships. They can inoculate physicians against burnout and help them sustain longer and happier careers.”

Medicine Grand Rounds, John B. Buse "Type 2 Diabetes Care: Struggle, Progress and the Future"
2016-10-13 12:00 - 13:00
Type 2 diabetes is a major and growing contributor to poor health outcomes globally. Clinical science has conclusively demonstrated that glycemic control reduces the risk of microvascular complications – eye, kidney and nerve disease. For cardiovascular disease, blood pressure and lipid management, smoking cessation and antiplatelet therapies are effective in reducing risk. However, great controversy regarding the utility of glycemic management to reduce cardiovascular disease has persisted. Further, treatment with insulin – the mainstay of late diabetes care – has been associated with increasing concerns about hypoglycemia and its impact on health outcomes and quality of care. Dr. Buse will review major trials published over the last 18 months that have revolutionized the landscape of type 2 diabetes care and suggest a new path forward to reduce the morbidity and mortality associated with the diabetes epidemic.
Dr. Buse’s practice combines clinical care, research and education. He has received international recognition for innovative efforts at prevention of type 1 diabetes, type 2 diabetes and their complications. He practices patient-centered care focusing on developing treatment programs in collaboration with patients that meet their needs and expectations. He works with teams of investigators in diabetes clinical trials, comparative effectiveness research and translation of basic science research towards clinical application. Current projects focus in novel treatments including development of glucose-responsive insulin, cardiovascular safety and efficacy of diabetes drugs and developing the evidence-base for treatment guidelines of the future in diabetes care.
Dr. Buse is Chief of the Division of Endocrinology, Director of the NC Translational and Clinical Sciences Institute, Director of the Diabetes Center and is the Executive Associate Dean for Clinical Research at the University of North Carolina School of Medicine. He has clinical practices at the UNC Highgate Specialty Center in Durham, NC and the Salem Center in Winston-Salem, NC. He enjoys lecturing about diabetes.

Grand Rounds: J. Kevin Harrison, MD
2016-10-17 12:00 - 13:00
Speaker: J. Kevin Harrison, MD, Professor of Medicine, Structural Heart Specialist, Duke UniversityTopic: “TAVR for Intermediate and Low Risk Aortic Stenosis Patients”

Medicine Grand Rounds, Roger S. Blumenthal "The ABC's of ASCVD Prevention"
2016-10-20 12:00 - 13:00
Roger S. Blumenthal, Director of Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, specializes in treating adults who are at higher risk for future cardiovascular events because of 1) a history of prior cardiovascular or peripheral arterial disease or 2) the presence of multiple coronary risk factors. Dr. Blumenthal’s principal clinical and research interests involve the optimal management of ischemic heart disease, noninvasive detection of coronary atherosclerosis, and the development of new strategies to optimize the management of cardiovascular disease risk factors.
Dr. Blumenthal is the Director of Preventive Cardiology at Johns Hopkins. He is a member of the official national spokesperson panel for the American Heart Association and was also chairman for four years of the American College of Cardiology Committee for the prevention of cardiovascular disease.
An experienced writer, Dr. Blumenthal is on the editorial board of The American Heart Journal, Clinical Cardiology and is the Preventive Cardiology/Coronary Heart Disease section editor of Cardiology Today.

2016 North Carolina Cardiovascular Update
2016-10-21 12:30 - 2016-10-22 12:00
Featuring The 15th Annual Ernest and Hazel Craige Lecture
KEYNOTE SPEAKER Roger S. Blumenthal, MDDirector, Johns Hopkins Ciccarone Centerfor the Prevention of Heart DiseaseThe Kenneth Jay Pollin Professor of CardiologyJohns Hopkins Professor of Medicine & Epidemiology

PROGRAM DIRECTORS

George A. (Rick) Stouffer, III, MDChief, Division of CardiologyHenry A. Foscue Distinguished Professor of MedicineMedical Center Physician in Chief, UNC Heart & Vascular Service Line

Eugene H. Chung, MDAssociate Professor of Medicine, UNC School of Medicine
View event brochure

Register for this event

Medicine Grand Rounds, Brian C. Jensen "Cardio-Oncology: What? Why? Who?"
2016-10-27 12:00 - 13:00
Dr. Jensen is a physician-scientist with a clinical and investigative focus on heart failure. He has clinical certification in Advanced Heart Failure/Transplantation and spends three months of the year as an attending physician on the UNC Heart Failure/Transplant/LVAD inpatient service. He also staffs the UNC Cardio-oncology clinic with a particular interest in optimizing cardiovascular health in patients with cancer. His laboratory uses mouse and cell culture models to study cardiac hypertrophy, heart failure, and the molecular response to myocardial injury.
Dr. Jensen’s research interests include heart failure, cardiac hypertrophy myocardial biology, adrenergic receptor biology, and chemotherapeutic cardiotoxicity. His clinical interests include advanced heart failure, transplant, and LVAD.

McAllister Heart Institute Seminar Series: Anne Eichmann, Ph.D
2016-10-31 11:00 - 12:00
Speaker: Anne Eichmann, Ph.D, Ensign Professor of Medicine, Yale University

Grand Rounds: Jonathan Rich MD
2016-10-31 12:00 - 13:00
Speaker: Jonathan D. Rich, MD. Professor of Medicine-Cardiology, Northwestern University.Topic: “Clinical Experience with HVAD Patient Management: Waveforms, BP and ASA.”

Medicine Grand Rounds, Richard W. Light "Pleural Disease Update 2016"
2016-11-03 12:00 - 13:00
Dr. Light is presently Professor of Medicine at Vanderbilt University in Nashville, Tennessee.
Dr. Light is best known for his research on pleural disease. He developed Light’s criteria for the separation of transudates and exudates in 1972. Subsequently, he has published many papers concerning the pathogenesis, diagnosis and management of pleural disease. Dr. Light is the editor of 12 books; the two most famous are the single authored monograph Pleural Diseases–now in its fifth edition–and The Textbook of Pleural Disease which he edits in conjunction with Dr. YC Gary Lee. Dr. Light has now been an author on more than 350 articles and has spoken in 43 countries.
In this lecture, Dr. Light will discuss the separation of transudates and exudates. He also will outline the usual tests that he recommends be obtained when a thoracentesis is performed. He will talk about the options available to diagnose a pleural effusion when no diagnosis is apparent after the initial thoracentesis. Lastly, he will describe the treatment of parapneumonic effusions and malignant pleural effusions.
His expertise includes the use of transforming growth factor beta to produce a pleural effusion, studies of the characteristics of pleural fluid with different diseases, development of a model of empyema in the rat, and the relationship between pulmonary hypertension and the presence of pleural effusions.

Medicine Grand Rounds, Morbidity & Mortality, "Perioperative Delirium"
2016-11-10 12:00 - 13:00
Dr. Andrew Greganti will present a clinical case of a patient who developed perioperative delirium that “unmasked” an underlying dementia. The case reminds caregivers that elderly patients who are at risk for cognitive decline can rapidly deteriorate after the stress of surgery and hospitalization.
Dr. Lindsay Wilson is an Assistant Clinical Professor in the Division of Geriatric Medicine with a special interest in delirium as it presents in older patients. She sees clinic patients at the UNC Geriatric Specialty Clinic, The Cedars Retirement Community, and Galloway Ridge, where she is the Associate Medical Director. She will offer her insights into the case and will identify ways to improve the care of patients who are at risk of developing delirium.
Dr. Greganti specializes in the care of elderly patients and the differential diagnosis of complex disease processes. He is Vice Chair of the Department of Medicine with primary responsibility for grand rounds.

Medicine Grand Rounds, Drs. Rick Stouffer and Alan Hinderliter, "Renal Denervation in the Treatment of Hypertension"
2016-11-17 12:00 - 13:00
Drs. Rick Stouffer and Alan Hinderliter will discuss renal denervation at the Department of Medicine Grand Rounds

Medicine Grand Rounds, Alan Hinderliter and Rick Stouffer "Renal Denervation in the Treatment of Hypertension"
2016-11-17 12:00 - 13:00
Drs. Hinderliter and Stouffer will discuss treatments for resistant hypertension with a focus on renal denervation, a novel device-based therapy. This minimally invasive procedure employs a catheter that emits a radio frequency (RF) energy across multiple electrodes. The RF energy is delivered to a renal artery via standard femoral artery access. A series of 1-minute ablations are delivered along each renal artery to disrupt the nerves. This procedure does not involve a permanent implant.
Dr. Hinderliter’s principal clinical interests are hypertension and echocardiography. He is a hypertension specialist and sees patients with high blood pressure that is difficult to control in the multidisciplinary UNC Hypertension Clinic. Dr. Hinderliter serves as the director of the UNC Hospitals echocardiography laboratory and provides imaging support to the structural heart disease program. He also works closely with the kidney transplant program in evaluating risk of cardiovascular events in patients who are considering a transplant. His research has focused on the effects of exercise, diet, and weight loss on high blood pressure, and on novel therapies for resistant hypertension.
Dr. Stouffer is an active clinician with a focus on smooth muscle cell growth regulation. He also has an interest in new treatments for hypertension, with his work being cited in multiple medical publications. His study on survival rates for in-hospital heart attacks was recently featured in The Wall Street Journal. With a strong research emphasis on advanced interventional cardiology treatments and procedures, Dr. Stouffer also studies coronary and peripheral interventions. He has also focused additional research on hemodynamics, valvular heart disease, coronary artery disease, renal artery stenosis, acute coronary syndromes, and stents.

Grand Rounds: John Douglas, MD
2016-11-28 12:00 - 13:00
Speaker: John S. Douglas, MD, Professor of Medicine, Director of Interventional Cardiology, Emory University.Topic: “Hypertrophic Cardiomyopathy: Current Therapeutic Options.”

McAllister Heart Institute Seminar Series: Lawrence L. Rudel, Ph.D
2016-11-29 11:00 - 12:00
Speaker: Lawrence L. Rudel, Ph.D, Professor, Internal Medicine, Wake Forest University
Topic: “Decreasing cholesterol ester secretion via SOAT2 inhibition limits atherosclerosis: A target for treatment of CHD”

Medicine Grand Rounds, Claire M. Doerschuk "Pneumonia: Homeland Security in the Lungs!"
2016-12-01 12:00 - 13:00
Dr. Doerschuk’s Grand Rounds will focus on host defense in the lungs, particularly how the lungs defend themselves against common stimuli such as bacterial pathogens and tobacco smoke. Airway epithelial cells, lung macrophages and neutrophils contribute to host defense. These cells and the processes they regulate synergize to result in an integrated response. This response can go awry in many ways, which often inform us about important mechanisms. Therapeutic interventions hold potential at many steps in this response.
Dr. Doerschuk’s research addresses host defense mechanisms in the lungs, particularly the inflammatory and innate immune processes that are important in the pathogenesis and course of bacterial pneumonia, acute lung injury/acute respiratory distress syndrome, and cigarette-smoke induced lung disease. Basic and translational studies address the mechanisms of host defense during pneumonia that focus on leukocyte recruitment, edema, and lung injury. These studies investigate pathogens that cause community-acquired and nosocomial pneumonias occurring in immunocompromised patients with cancer. Although these processes are important in all inflammatory lung diseases, her work particularly addresses pneumonia and the acute respiratory distress syndrome using in vivo, translational, cell biological, immunological, and molecular approaches. Her ultimate goal is to use this knowledge to develop therapies that enhance the inflammatory response when it is beneficial to the host and dampen this response when it is harmful.
