McAllister Heart Institute Seminar Series: Domenick Prosdocimo, Ph.D
2016-12-06 11:00 - 12:00 (America/New_York) | NC
Speaker: Domenick Prosdocimo, Ph.D, Instructor of Medicine,Case Western Reserve University
Topic: “Kruppel-like factor 15 regulates cardiac lipid metabolism”

Medicine Grand Rounds, Marco Patti "Gastroesophageal Reflux Disease: From Heartburn to Lung Fibrosis and Beyond"
2016-12-08 12:00 - 13:00
This lecture will focus on the relationship between GERD and respiratory disorders–in particular, the possible cause and effect relationship between GERD and Idiopathic Pulmonary Fibrosis. Dr. Patti will review the possible role of GERD in rejection after lung transplantation. Strategies for addressing these problems will be presented.
Marco G. Patti, MD, is an internationally known surgeon with extensive expertise in the surgical treatment of esophageal diseases. He is one of the few surgeons in the United States who focus entirely on the surgical treatment of esophageal disease, specializing in treatment of swallowing disorders, acid reflux and esophageal cancer.
Patti is an authority on the use of minimally invasive surgical techniques to treat esophageal conditions. Performed through very small incisions with the use of specialized instruments and miniature cameras, this approach can lead to a quicker and more comfortable recovery, a shorter hospital stay and minimal scarring. “Because some of these disorders are so common, many people tend to live with the discomfort rather than seek treatment,” said Patti. “So when they finally come to us, they already have fairly advanced disease.”
Gastroesophageal reflux disease, known as GERD, affects an estimated two to three percent of adults. In patients with GERD, a muscle that separates the esophagus from the stomach does not close properly. This allows stomach contents to leak back, or reflux, into the esophagus and irritate it. Although GERD can usually be treated with lifestyle and diet changes combined with medication, chronic reflux can cause serious complications. Repeated exposure to stomach acid can damage the esophagus and cause bleeding or ulcers. Scar tissue can narrow the esophagus and impair swallowing. Some patients with chronic GERD develop Barrett’s esophagus, in which some of the lining of the esophagus is replaced by tissue similar to that in the intestine. This condition, which affects about 700,000 adults in the United States, can progress to esophageal cancer, which is often fatal.
“Physicians are slowly becoming more aggressive about treating these disorder before the complications begin,” Patti said. “I have seen too many patients who slowly develop serious damage while struggling with ineffective medications, when a simple operation could have solved the problem.”

Grand Rounds: Sarah Ciccotto, MD
2016-12-12 12:00 - 13:00
Speaker: Sarah Ciccotto, MD, UNC Cardiology FellowTopic: “Cardiovascular Disease in Women: Unique Risk Factors and Implications for Primary Prevention.”

Medicine Grand Rounds, Eric Klett, Louise Newton and Keelee MacPhee "A Multidisciplinary Approach to the Care of Transgender Patients"
2016-12-15 12:00 - 13:00
Dr. Eric Klett, Dr. Keelee MacPhee, J. Louise Newton will provide an overview of the diagnosis and care of patients with Gender Dysphoria. Diagnostic criteria for Gender Dysphoria as well as adherence to the standards of care will be discussed for medical providers who may come into contact with the transgender population in their practice.
Dr. Klett practices General Endocrinology at UNC with clinical interests in thyroid disease, lipid disorders and transgender medicine.
Ms. Newton is the Clinical Director of Psychotherapy at Carolina Partners in Mental HealthCare. She has been a clinical educator and advocate of access to treatment for LGBTQI communities since 2001 and specializes in working with transgender and gender variant folks; many of whom are seeking assistance in removing barriers to medical care. Ms. Newton has also worked during this time educating providers about best practices in working with transgender and gender nonconforming patients.
Dr. MacPhee has been performing gender reassignment procedures since 2005. Working with the transgender and non-binary patient population, she has seen first-hand the positive and profound effects that surgical reconstruction can have on a person’s life. Dr. MacPhee practices at Renaissance Plastic & Reconstructive Surgery in Raleigh.

Medicine Grand Rounds, Will Pendergraft "These Are Your Kidneys on Lupus"
2016-12-22 12:00 - 13:00
Dr. Will Pendergraft is Assistant Professor of Medicine in the Division of Nephrology. His specialty areas include Glomerular disease, vasculitis (with primary focus on ANCA vasculitis), lupus nephritis, and drug-induced autoimmune disease.
In this lecture, Dr. Pendergraft will describe the impact of lupus on the kidneys and review the current clinical and translational states of lupus nephritis, including the first successful clinical trial in lupus nephritis. Lupus nephritis is the term used when lupus causes inflammation in the kidneys, making them unable to properly remove waste from blood or control the amount of fluids in the body. Abnormal levels of waste can build up in the blood and edema can develop. Left untreated, nephritis can lead to scarring and permanent damage to the kidneys and possibly end-stage renal disease, requiring dialysis or a kidney transplant. It is estimated that as many as 40 percent of all people with lupus, and as many as two-thirds of all children with lupus, will develop kidney complications that require medical evaluation and treatment.
Dr. Pendergraft provides medical care for patients with kidney disease, educates trainees about nephrology, and conducts translational and clinical research with a special emphasis on autoimmune diseases that affect the kidneys. His other research interests include:

Understanding response to therapy and relapse in lupus nephritis and ANCA vasculitis using high-resolution systems-level tools (epigenetic, transcriptomic, metabolomic, proteomic and microbiomic)
Repurposing FDA-approved drugs for use in lupus nephritis and ANCA vasculitis
Translational studies aimed at understanding drug-induced forms of ANCA vasculitis
Clinical trials of existing and novel biologic therapies for lupus nephritis and ANCA vasculitis
Clinical data analysis of large and unique cohorts of patients with either lupus nephritis, ANCA vasculitis or idiopathic membranous nephropathy
In-depth characterization of rituximab use and development of guidelines to prevent and manage adverse event

Medicine Grand Rounds, Raj Kasthuri and Jian Liu, "Heparins: Into the Second Century"
2017-01-05 12:00 - 13:00
Dr. Raj Kasthuri is Associate Professor of Medicine in the Division of Hematology and Oncology and is the Director of the UNC HHT Center of Excellence. Dr. Kasthuri earned his medical degree from the Kasturba Medical College in India. He completed his fellowship in Hematology and Medical Oncology at the University of Minnesota. He is a member of the UNC Hemophilia and Thrombosis Center and the UNC McAllister Heart Institute. Dr. Kasthuri’s clinical and research interests are in bleeding and clotting disorders, and HHT.
Dr. Jian Liu is the John & Deborah McNeill, Jr. Distinguished Professor in the UNC Eshelman School of Pharmacy. He has been working with heparin for more than 25 years. His expertise is in structural characterization of heparin and heparan sulfate, biosynthetic mechanism of heparin and enzymatic synthesis of heparin. He has invented an enzyme-based method to prepare heparin and heparan sulfate from bacteria polysaccharides. His method could potentially manufacture heparin in a confined facility to improve the safety of heparin drug.

Medicine Grand Rounds, Melina Kibbe, "Sex Bias in Biomedical and Clinical Research"
2017-01-12 12:00 - 13:00
Melina R. Kibbe is the Zack D. Owens Distinguished Professor and Chair of the Department of Surgery. She also is an Adjunct Professor in the Department of Biomedical Engineering. Prior to UNC, Dr. Kibbe was faculty at Northwestern University for 13 years where she also served as the Vice Chair of Research in the Department of Surgery and as Deputy Director of the Simpson Querrey Institute for BioNanotechnology. Clinically, Dr. Kibbe has significant experience with both open and endovascular surgery, including the treatment of carotid stenosis, peripheral vascular disease, and abdominal aortic aneurysms. She is board certified in general and vascular surgery and is RVT and RPVI certified by ARDMS.
Dr. Kibbe has been a strong advocate for sex inclusion in biomedical research. She was interviewed by Leslie Stahl for 60 Minutes in February 2014 on this topic, and later appeared on The Colbert Report. Her publications on the presence of sex bias in surgical research gained much media attention nationally and internationally, and resulted in policy development with the National Institutes of Health, the Government Accountability Organization (GAO), and the FDA. In addition, a bill has been introduced into the House, “Research for All Act of 2015,” which hopefully will be voted into law.

Medicine Grand Rounds, Marie Demay, "FGF23 in Normal Physiology and Disease"
2017-01-19 12:00 - 13:00
FGF23 was initially identified by linkage analysis of a rare genetic disorder characterized by rickets and hypophosphatemia. Subsequent investigations identified FGF23 as a major regulator of mineral ion homeostasis under normal physiological conditions. Increased levels of FGF23 contribute to the pathology observed in numerous disease states, including chronic kidney disease. This lecture will discuss the physiologic role of FGF23 and its contributions to disease pathology.
Marie Demay is Professor of Medicine at Harvard Medical School. Her clinical interests include calcium disorders, endocrinology, and osteomalacia. Her current research projects include the role of the vitamin D receptor in keratinocyte stem-cell function and the role of mineral ions and hormones on growth-plate development and maturation using a model of X-linked hypophosphatemia.

Medicine Grand Rounds, David Weber and Sarah McGill, "Clostridium Difficile Infection"
2017-01-26 12:00 - 13:00
Drs. Weber and McGill will discuss Clostridium difficile, often called C. diff, a bacterium that can cause symptoms ranging from diarrhea to life-threatening inflammation of the colon. Illness from C. difficile most commonly affects older adults in hospitals or in long term care facilities and typically occurs after use of antibiotic medications.
In recent years, C. difficile infections have become more frequent, more severe and more difficult to treat. Each year, tens of thousands of people in the United States get sick from C. difficile, including some otherwise healthy people who aren’t hospitalized or taking antibiotics.
Treatment of C. difficile infections costs more than $3 billion per year in the U.S. alone. C. diff is one of the most dangerous drug-resistant infections. As a result, it’s classified as an “urgent threat” by the Centers for Disease Control and Prevention, making it a top priority for microbial researchers. Fecal microbiota transplantation is an effective treatment for recurrent C. difficile positive diarrhea. The Food and Drug Administration allows fecal transplantation to be performed in patients whose C. difficile infection has not responded to standard therapies.
Through his roles as medical director of hospital epidemiology and associate chief medical officer of UNC Health Care, Dr. Weber works to prevent hospital-acquired infections in patients and staff at UNC Hospitals. Dr. McGill cares for patients with recurrent C. difficile colitis and performs fecal transplant. She will examine the indications for fecal transplantation and how it is performed at UNC.

Grand Rounds: Akinniran Abisogun, MD
2017-01-30 12:00 - 13:00
Speaker: Akinniran Abisogun, MD, UNC Cardiology Fellow, Topic: “Management and Outcomes of Non-ST Elevation Myocardial Infarction in Patients Hospitalized for Non-Cardiac Conditions.”

Medicine Grand Rounds, Balfour Sartor, "Intestinal Microbiota in Health and Inflammatory Diseases: The Basis for Improved Therapeutic Manipulation"
2017-02-02 12:00 - 13:00
Dr. Sartor is a gastroenterologist and mucosal immunologist with a long-standing interest in mechanisms by which commensal microbiota induce chronic intestinal inflammation vs. mucosal homeostasis. He specializes in inflammatory bowel diseases (IBD) and directs the UNC Multidisciplinary IBD Center. Dr. Sartor has been a faculty member at UNC for his entire academic career. His research is focused on developing and applying rodent models of chronic, immune-mediated intestinal inflammation relevant to IBD and performing clinically relevant translational studies of IBD patients. Dr. Sartor investigates host genetically programmed immune responses to luminal commensal microbial products using gnotobiotic rodents and patient-derived samples and studies the influence of diet and environmental factors on intestinal microbiota composition and function.

Medicine Grand Rounds, Morbidity & Mortality, "Tachycardia-Induced Cardiomyopathy"
2017-02-09 12:00 - 13:00
Dr. Andrew Greganti will review the clinical course of a patient who initially presented with a polymyalgia rheumatica syndrome and whose prolonged illness was complicated by a cardiomyopathy of unclear pathogenesis.
Dr. Anil Gehi is an electrophysiologist in the UNC Center for Heart & Vascular Care specializing in pacemaker and defibrillator implantation, device extraction, catheter ablation for SVT, VT, and atrial fibrillation. He is involved with research studies on atrial fibrillation with respect to symptom relief and catheter ablation. Whether by performing a catheter ablation, implanting a device, or simply providing reassurance that worrisome symptoms are benign, he enjoys helping patients through their illness. He also works to improve the lives of patients with cardiac dysrhythmia by advancing systems of care and developing more precise ablation techniques. Finally, he helps future physicians acquire knowledge and skills for success in medicine, cardiology, and electrophysiology.
Dr. Greganti specializes in the care of elderly patients and the differential diagnosis of complex disease processes. He is Vice Chair of the Department of Medicine with primary responsibility for grand rounds.

Department of Medicine Grand Rounds: Dr. M. Andrew Greganti and Dr. Anil Gehi
2017-02-09 12:00 - 13:00
Speakers: Dr. M. Andrew Greganti (Vice Chair, Department of Medicine; Professor of Medicine, Division of Geriatric Medicine) and Dr. Anil Gehi (Associate Professor of Medicine, Division of Cardiology)Topic: Tachycardia-Induced Cardiomyopathy

McAllister Heart Institute Seminar Series: Mark Kahn, MD
2017-02-10 12:00 - 13:00
Speaker: Mark Kahn, MD (Edward Cooper, MD and Norman Roosevelt & Elizabeth Meriwether McLure Professor, University of Pennsylvania-Perelman School of Medicine)Topic: Cerebral Cavernous Malformation: From Mechanism to Therapy

UNC Stem Cell Seminar - "Cytoskeletal Vetting of Mechanical Signals that Determine Mesenchymal Step Cell Fate" with Dr. Janet Rubin
2017-02-13 16:00 - 17:00

McAllister Heart Institute Seminar Series: Walter Koch, PhD
2017-02-14 16:00 - 17:00
Speaker: Walter Koch, PhDTopic: Targeting GRK2 in The Failing Heart

GI Epi Conference - "Carolina Data Warehouse and I2B2" with Emily Pfaff
2017-02-15 16:00 - 17:00

Medicine Grand Rounds, Timothy Ives and Maryam Jowza, "Opioid Use and Misuse"
2017-02-16 12:00 - 13:00
The US is in the midst of an opioid overdose epidemic. Overdose deaths involving prescription opioids have quadrupled since 1999, and so have sales of these prescription drugs. Efforts to address the opioid epidemic have focused mainly on reducing non-medical opiate use. Overprescribing of opiate agents has led to a sharp increase in the prevalence of opioid addiction, which is also associated with a rise in overdose deaths and heroin use. A multifaceted public health approach is required to effectively reduce opioid-related morbidity and mortality. The scope of options to manage patients with chronic pain issues, along with strategies to mitigate the risks associated with opioid agents, will be discussed during this Medicine Grand Rounds.

Dr. Timothy Ives is the Director of Pain Management Service, Division of General Medicine and Clinical Epidemiology, Professor of Medicine and Professor of Pharmacy. His research interests are in the area of inflammation and chronic pain management, with neuropathic pain in particular.
Dr. Maryam Jowza is Assistant Professor of Anesthesiology. She treats a wide range of pain conditions from acute post-surgical pain to chronic musculoskeletal disorders, cancer-related pain and neuropathic conditions. She also has a special interest in treating pain in children.

CGIBD Research Seminar - "Gut Feelings for Eating Disorders"
2017-02-16 16:30 - 17:30
Livestream this presentation: https://meetings.webex.com/collabs/meetings/join?uuid=M5RXAAYEB6V25IX0KLDM6C9ZSK-12JV

GI Epi Conference: "Work in Progress" - Drs. Bharati Kochar and Craig Reed
2017-02-22 16:00 - 17:00

Medicine Grand Rounds, Anne R. Cappola, "Challenges in Thyroid Hormone Replacement"
2017-02-23 12:00 - 13:00
Dr. Anne Cappola is a Professor of Medicine in the Division of Endocrinology, Diabetes, and Metabolism at the University of Pennsylvania. She is Director of the Clinical and Translational Research Center and Director of Clinical Research for the Department of Medicine. She is an Associate Editor for the Journal of the American Medical Association.
Dr. Cappola’s research focuses on the hormonal alterations that occur with aging and the clinical impact of these changes. She is funded by the National Institute on Aging. Current projects include studies of the indications for treatment of subclinical thyroid dysfunction in older men and women; the role of androgens in the health of older women; hormonal treatments for the frailty syndrome; and metabolic changes in men and women who sustain a hip fracture.
Her lecture will focus on subclinical hypothyroidism in the elderly, combination treatment with T4+T3, thyroid hormone extracts, and information about nutraceuticals — “natural” treatments.

CGIBD Seminar - Dr. Melina Kibbe, Chair, Dept of Surgery
2017-02-23 16:30 - 17:30
Watch online: https://meetings.webex.com/collabs/meetings/join?uuid=M5RXAAYEB6V25IX0KLDM6C9ZSK-12JV

3rd Annual Women's Heart Symposium
2017-02-25 08:00 - 16:00
Paula Miller, MD (Clinical Associate Professor, Medical Director of Cardiac Rehabilitation, and Director of the Women’s Heart Program at the UNC School of Medicine) will be hosting the event and giving an overview of heart disease in women.
Topics at the Symposium include

An overview of heart disease in women
Heart failure in women
Device therapy in women: cardiac electrophysiology, pacemakers, defibrillators, and more
Cardiovascular disease and exercise
Cardiovascular disease and nutrition
Cardiovascular disease and stress
Stretching for health

Lunch will be provided at this FREE event (choice of salmon or a grilled vegetable entrée).Participants will also receive a free t-shirt.To register, please contact Barbara Reid at (919)843-5205 or breid@med.unc.edu.Information required: first & last name, email address, phone number, t-shirt size (S, M, L).
Please register by February 23.

GI Epi Conference - "Work in Progress" with Jeff Yang
2017-03-01 16:00 - 17:00

Medicine Grand Rounds, Stephan Moll, "Thrombophilia Evaluation: Choosing Wisely"
2017-03-02 12:00 - 13:00
Dr. Stephan Moll’s expertise is in thrombosis and anticoagulation. In this presentation, he will set forth clinically important facts about the pathophysiology, prevalence and thrombotic risk of inherited and acquired thrombophilias. In addition, he will describe which patient and family members to test for thrombophilia, what tests to obtain, and at what time to test. The implications of a thrombophilia on an individual’s health also will be presented, in addition to detailed information about how thrombophilia tests are done in the laboratory and what parameters (acute thrombosis, presence of anticoagulant) may influence the test results.
Dr. Moll is Professor of Medicine in the UNC Hemophilia and Thrombosis Center. His clinical interest is coagulation and classical hematology, with a particular focus on thrombosis and anticoagulation. Dr. Moll’s research interests include clinical trials on new anticoagulants, better use of established anticoagulants, antiphospholipid antibody syndrome and postthrombotic syndrome. He takes a special interest in clinical-medical education of patients, the public, and health care professionals. He is the cofounder of the thrombosis and anticoagulation education website Clot Connect – at www.clotconnect.org.

CGIBD Seminar - "Single-cell and High-throughput genomics core services at UNC." with Scott T. Magness, Ph.D.
2017-03-02 16:30 - 17:30

Stem Cell Seminar - "TGF-BETA2 Treatment to Reduce Bone Marrow-Derived Mesenchymal Steam Cell Immunogenicity"
2017-03-06 16:00 - 17:00

Integrative Vascular Biology/McAllister Heart Institute Annual Research Symposium
2017-03-07 09:00 - 17:00

GI Epi Conference - "Primary Care - Specialist Collaboration in the Care of Children with IBD: Using secondary data to identify opportunities to improve care of potential disease exacerbations." with Neal deJong, MD
2017-03-08 16:00 - 17:00

Medicine Grand Rounds, Tina Schade Willis, "Code Sepsis: Current Evidence Based Guidelines and CMS Core Measure"
2017-03-09 12:00 - 13:00
Because of the prevalence, seriousness, and treatability of sepsis, UNC Hospitals launched Code Sepsis, an initiative that aims to implement reliable screening for early detection of sepsis, educate multidisciplinary teams in evidence-based therapies, and standardize tools and treatment bundles for our specific patient populations.
Most patients and their families have never heard of sepsis, a condition that kills more people every year than breast cancer, prostate cancer, and AIDS combined. Studies show that when health-care providers promptly recognize sepsis and treat it by immediately administering antibiotics and fluids, survivorship increases by 50%. Although sepsis most often occurs in the elderly, the young, and those with chronic diseases such as cancer or liver disease, sepsis can affect perfectly healthy people of all ages. Every year, in fact, more than 1.6 million Americans develop sepsis during hospitalization, and nearly a quarter-million of those die from sepsis-related complications. A majority of sepsis survivors who are discharged are readmitted to the hospital within 30 days of leaving.
The important information delivered through this lecture will help our health-care providers better understand sepsis, the current progress of the initiative, and access to the tools and training materials that are being tested or implemented as part of the initiative.
Tina Schade Willis, MD, is Professor of Pediatric Critical Care Medicine, Associate CMO for Quality at UNC Hospitals, and Director of the UNC Institute for Healthcare Quality Improvement. Her academic focus includes system designs that reduce variation and cycle times leading to improved patient care, efficiency, and satisfaction. She is an expert in high performance team training, performance improvement study design, analysis, and management.
