McAllister Heart Institute Seminar Series: Dr. Lena Claesson-Walsh
2018-10-12 10:00 - 2018-10-13 11:00 (America/New_York)
Speaker: Dr. Lena Claesson-Walsh, Uppsala University

Medicine Grand Rounds, Gary Jay "Minor Traumatic Brain Injury, Chronic Traumatic Encephalopathy and Post Traumatic Headaches"
2018-10-11 12:00 - 13:00
Dr. Jay will discuss the diagnosis and pathophysiology of minor Traumatic Brain Injury, along with Chronic Traumatic Encephalopathy. He also will describe the most common forms of Post-Traumatic Headache, including diagnosis and treatment.
Gary Jay specializes in the diagnosis and treatment of headache and pain of all types including migraine with and without aura, chronic daily headaches, tension-type headaches (episodic and chronic), medication overuse headaches, cluster headache and other trigeminal autonomic cephalalgias. His research interests include analgesic drug development. Dr. Jay is a professor in the UNC Department of Neurology.
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McAllister Seminar Series: Dr. Brian Kim
2018-10-10 10:00 - 11:00
Speaker: Dr. Brian Kim, Stanford University

Medicine Grand Rounds, Katya Rubinow "Can Sex Steroids Help Elucidate the Utility of HDL As an Index of Cardiovascular Risk?"
2018-10-04 12:00 - 13:00
In epidemiologic studies, sex steroid deficiency predicts cardiovascular risk in both men and women, but the utility of hormone replacement therapy for reducing cardiovascular risk remains uncertain. Exogenous sex steroids regulate plasma concentrations of high-density lipoprotein cholesterol (HDL-C), but little is known about sex steroid-mediated effects on other metrics of HDL composition and function. Understanding the roles of sex steroids in regulating the function and composition of HDL particles may lend new insight into the cardioprotective potential of hormone replacement therapy and, further, may help elucidate the utility of HDL-based metrics for predicting cardiovascular risk on an individual basis.
Katya Rubinow, MD, is a board-certified physician at the Endocrinology/Diabetes Clinic at Harborview and a University of Washington assistant professor of Medicine and Metabolism, Endocrinology and Nutrition. Dr. Rubinow cares for patients with diabetes, thyroid disease and a broad spectrum of other endocrine disorders. She strives to help patients feel supported and understood and to provide information that will enable them to be powerful advocates for their own health.
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Medicine Grand Rounds, Christine Sinsky "Joy in Medicine"
2018-09-27 12:00 - 13:00
Professional satisfaction is a powerful driver of patient experience, quality of care and wise resource use. Burnout is widespread among physicians and is the result of health system dysfunctions, rather than weakness on the part of individuals. Improvements in clinical workflow, teamwork and leadership are among the most potent anecdotes to the burnout. This session will describe approaches that institutions and individual practices can take reduce burnout and improve the joy, purpose and meaning in work for health professionals.
Christine Sinsky, MD, is the vice president of professional satisfaction at the American Medical Association. She is also a practicing internist in Dubuque, Iowa, and the Chair of the American Board of Internal Medicine Foundation. A frequent invited lecturer on practice innovation, redesign and physician satisfaction, Dr. Sinsky has presented widely, both nationally and internationally.
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McAllister Heart Institute Seminar Series: Dr. Anne Marie Schmidt, "Rage/Diaph1 Mechanism of Diabetic Complications and Metabolic Dysfunction"
2018-09-26 10:00 - 11:00
Speaker: Dr. Anne Marie Schmidt, New York UniversitySubject: Rage/Diaph1 Mechanism of Diabetic Complications and Metabolic Dysfunction

Cardiovascular Grand Rounds: Dr. Bo Jiang, "Genetics of Coronary Artery Disease"
2018-09-24 12:00 - 13:00
Speaker: Bo Jiang, MD, UNC Cardiology FellowTopic: Genetics of Coronary Artery Disease

Medicine Grand Rounds, Todd Baron and Ian Grimm "Recent Advances in Therapeutic Endoscopy"
2018-09-20 12:00 - 13:00
Once deemed primarily diagnostic, endoscopy has quickly transcended to a minimally invasive intervention and therapeutic tool. This continuous evolution of the spectrum of endoscopy represents an active area of ongoing research and clinical care with tremendous biomedical potential. This review will focus on latest developments in the field of therapeutic endoscopy
Ian Grimm, MD, has been practicing advanced therapeutic gastrointestinal endoscopy for nearly 30 years and has had a longstanding interest in the non-surgical removal of complex polyps. In 2016, he undertook a sabbatical to study endoscopic submucosal dissection and per-oral endoscopic myotomy in Japan, where these techniques were initially developed. Dr. Grimm has served as director of the GI Procedures unit at UNC Memorial Hospital since 2000.
Todd Baron, MD, performs endoscopic treatment of complex gastrointestinal disorders, particularly management of pancreaticobiliary obstruction through the use of endoscopic retrograde cholangiopancreatography and endoscopic ultrasound. He also conducts extensive clinical research in endoscopic management of diseases throughout the gastrointestinal tract. Dr. Baron is Director of Advanced Therapeutic Endoscopy at UNC.
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Department of Medicine Faculty Meeting CANCELLED
2018-09-13 12:00 - 13:00

Cardiovascular Grand Rounds: Dr. Cory Henderson, “Cardiac CT: A Review of Clinical Applications"
2018-09-10 12:00 - 13:00
Speaker: Cory Henderson, UNC Cardiology FellowTopic: Cardiac CT: A Review of Clinical Applications

Medicine Grand Rounds, Ria Dancel "POCUS: Power and Pitfalls"
2018-06-14 12:00 - 13:00
Dr. Ria Dancel
Ria Dancel specializes in the care of hospitalized adults and children, bedside ultrasound at the point of care, ultrasound guided procedures, resident education. Dr. Dancel’s area of clinical interest and quality improvement research focuses on point of care ultrasound (POCUS) as a diagnostic tool and an instrument to increase patient safety during invasive bedside procedures.
Dr. Dancel is Director of the Medicine Procedure Service, and Associate Chief of Education and Faculty Development in the Division of Hospital Medicine. She is an associate professor in the Departments of Internal Medicine and Pediatrics.

Medicine Grand Rounds, Richard Boucher "Muco-Obstructive Lung Diseases: Mucus Concentration and Relationship to Bronchitis"
2018-06-07 12:00 - 13:00
Richard Boucher is James C. Moeser Eminent Professor of Medicine and Director of Marsico Lung Institute. Dr. Boucher’s lab has focused on the normal physiology of airway surface liquids (ASL) and how this system fails in airways diseases, e.g., cystic fibrosis and COPD. The lab pursues a variety of investigations into the functions of airway epithelia in health and disease.

Medicine Grand Rounds, Saira Sheikh “BAFFling New Lupus Therapies – Looking to the Future After Decades of Failed Clinical Trials”
2018-05-31 12:00 - 13:00
Systemic lupus erythematosus (SLE) is a chronic, debilitating autoimmune disease with heterogeneous manifestations ranging from scarring skin rash or arthritis to severe, organ-threatening involvement of the kidneys, heart, lungs or central nervous system. SLE is characterized by the presence of autoantibodies against nuclear antigens, which are thought to be caused by dysregulation of the immune system. Development of new therapies is critical due to unmet needs associated with SLE, including inadequate disease control, poor health-related quality of life, medication toxicities and increased morbidity and mortality.
One challenge in caring for patients with SLE is a lack of approved and efficacious medications. Randomized controlled trials evaluating novel biologic immune modulators in SLE have been largely unsuccessful at achieving the primary endpoints needed for FDA approval. Efforts to develop therapies against specific molecular targets in SLE has resulted in the identification of BAFF (B-cell activating factor) inhibitors to treat the disease. This talk will provide a summary of that journey and a brief overview of what’s on the horizon for SLE therapies.
Dr. Saira Sheikh is an Assistant Professor of Medicine, Director of Clinical Trials Program at the UNC Thurston Arthritis Research Center and Director of the UNC Rheumatology Lupus Clinic. Dr. Sheikh’s work has been focused on building a Collaborative Lupus Clinical & Research Program that directly impacts the care of patients. She is working on a national level to develop programs that address racial disparities in lupus clinical trials.

Medicine Grand Rounds, Tony Mazzella, Rosanne Tiller, Russell Coletti, and Alyssa Tilly, "Chief Resident Year in Review"
2018-05-24 12:00 - 13:00
Tony Mazzella and Rosanne Tiller will present Multidisciplinary Bedside Rounds, their project to restructure rounds with a consistent multidisciplinary team presence at the patients’ bedsides to have a clinical discussion with the most important team member: the patient.
Alyssa Tilly will discuss the Professional Development Coaching Program, a modality to promote resilience and combat burnout by allowing those who are being coached to self-identify positive individual traits and experiences.
Russell Coletti will present Expected Practices Tool, a quality improvement measure to enhance the initial care of patients with Rheumatoid Arthritis. This tool can be expanded to other medical conditions, improving patient care by fostering collaboration between primary care and specialty practices.

McAllister Heart Institute Seminar Series: David Zawieja, PhD, "Lymphatics: the link between the parenchyma, cardiovascular and immune systems"
2018-05-22 14:00 - 15:00
Speaker: David Zawieja, PhD, Regents Professor and Department Head of Medical Physiology, Texas A&M University College of MedicineTopic: Lymphatics: the link between the parenchyma, cardiovascular and immune systems

Medicine Grand Rounds, Sascha Tuchman and Koyal Jain, "Amyloidosis, Cyanide, Myeloma and Ethanol: Conceptualizing Renal Diseases Caused by Monoclonal Gammopathies"
2018-05-17 12:00 - 13:00
Monoclonal gammopathies are a group of plasma cell or B-cell disorders including true cancers such as multiple myeloma or “sort-of cancers” such as light chain amyloidosis. These disorders in many cases cause no injury to a person (i.e., monoclonal gammopathy of undetermined significance [MGUS]) but when they do cause injury, the pattern of injury can be quite varied and often includes the kidneys. Monoclonal gammopathy of renal significance (MGRS) is a recently described category of nephrotroxic monoclonal gammopathies that arise in the absence of an overt hematologic malignancy. Monoclonal gammopathies overall have been increasingly recognized as a cause of renal failure. Over 660,000 Americans have kidney failure, and early recognition of the etiology of kidney disease can prevent progression to end-stage kidney disease through aggressive interventions, such as chemotherapy in proven cases of multiple myeloma or MGRS. The management of these patients requires close collaboration between nephrologists and oncologists. In this presentation, we will be focusing on the wide spectrum of diseases associated with nephrotoxic plasma cell disorders, with a focus on how to conceptualize them clinically.
Sascha Tuchman is a UNC Comprehensive Cancer Center member and Associate Professor of Medicine. Dr. Tuchman’s research has a special focus on amyloidosis and multiple myeloma.
Koyal Jain is an Assistant Professor of Medicine in the Nephrology division. She specializes in acute kidney injury and chronic kidney disease, dialysis management, high blood pressure management, abnormalities of electrolytes like sodium, potassium, calcium, and glomerular diseases.

Medicine Grand Rounds, Steven Russell "The Bionic Pancreas"
2018-05-10 12:00 - 13:00
The bionic pancreas system proved better than either conventional or sensor-augmented insulin pump therapy at managing blood sugar levels in patients with type 1 diabetes living at home, with no restrictions, over 11 days. “For study participants living at home without limitations on their activity and diet, the bionic pancreas successfully reduced average blood glucose, while at the same time decreasing the risk of hypoglycemia,” says Steven Russell. “This system requires no information other than the patient’s body weight to start, so it will require much less time and effort by health care providers to initiate treatment. And since no carbohydrate counting is required, it significantly reduces the burden on patients associated with diabetes management.”
Since 2006 Steven Russell has collaborated on this project with Dr. Edward Damiano, a Biomedical Engineer at Boston University. The trials are scheduled to begin in the fourth quarter of 2018.

Cardiovascular Grand Rounds: Olga Bokeriya, MD, PhD, FACC, "The Russian National Center for Cardiology and Cardiovascular Surgery: Extensive Experience and Creative Innovations"
2018-05-07 12:00 - 13:00
Speaker: Olga Bokeriya, MD, PhD, FACC, Professor of Cardiology; Chief, Department of Cardiac Surgery; Chief Scientist and Physician for Bakoulev National Medical and Research Center for Cardiovascular Surgery and Ministry for Healthcare, Russian Federation in MoscowTopic: “The Russian National Center for Cardiology and Cardiovascular Surgery: Extensive Experience and Creative Innovations”

Medicine Grand Rounds Blythe Lecture, Mark Zeidel "Salt and Water, Not So Simple"
2018-05-03 12:00 - 13:00
Dr. Blythe was an expert in salt and water homeostasis. This lecture will use a case-based approach to review the overall principles of salt and water homeostasis, and will describe new paradigms in long term salt balance, the storage of salt in the tissues and the neural control of salt appetite and thirst. Future advances in salt and water homeostasis will enhance the therapy of hypertension and shock, as well as disorders of water metabolism.
Dr. Mark Zeidel is Herrman L. Blumgart Professor of Medicine at Harvard Medical School, and Chair and Physician-in-Chief at Beth Israel Deaconess Medical Center in Boston. His research has been recognized by the American Physiological Society, the American Society for Clinical Investigation and the Association of American Physicians. His research has received continuous funding by the NIH for more than 30 years.
Every one to three years, the Division of Nephrology and Kidney Center invites a lecturer to honor the memory of Dr. William Blythe, II. Dr. Blythe, the first Division Chief for Nephrology and Hypertension at UNC, was an outstanding physician-scientist and teacher who inspired many of us to pursue nephrology. He was also a gifted man of letters.

Medicine Grand Rounds, Paul Hayashi "Liver Transplantation: Pre-Transplant Criteria and Long-Term Management"
2018-04-26 12:00 - 13:00
Dr. Hayashi is Associate Professor of Medicine and Medical Director of Liver Transplantation. UNC’s Liver Transplant Program opened in the Fall of 1991. From the beginning, UNC’s Transplant Team has been committed to providing patients with the highest quality care and access to the newest, most effective therapies. Located in UNOS Region 11, our transplant patients have come from around the nation.
Comprehensive care is provided to all transplant patients and recipients using a multi-disciplinary team approach. The UNC Liver Transplant Team includes transplant surgeons, hepatologists, nurse practitioners, nurse coordinators, social worker, psychologists, and financial counselors.
Dr. Hayashi is involved in clinical research regarding transplant outcomes, hepatocellular carcinoma screening, cirrhosis management, and drug-induced liver injury.

McAllister Heart Institute Seminar Series: Melina Kibbe, MD, "When Mice are Men: Sex Bias in Surgical Research"
2018-04-24 11:00 - 12:00
Speaker: Melina Kibbe, MD, Colin G. Thomas Jr. Distinguished Professor and Chair, Department of Surgery, UNCTopic: “When Mice are Men: Sex Bias in Surgical Research”

Cardiovascular Grand Rounds: Anil Gehi, MD, "An Integrated Approach to A-Fib Patient Care"
2018-04-23 12:00 - 13:00
Speaker: Anil Gehi, MD, Associate Professor of Medicine, Director, Clinical Cardiac Electrophysiology Service, UNCTopic: “An Integrated Approach to A-Fib Patient Care”

Medicine Grand Rounds Earley Lecture, Marschall Runge "Man vs. Machine: The Optimal Combination to Improve Health Care Outcomes"
2018-04-19 12:00 - 13:00
Dr. Runge is executive vice president for Medical Affairs at the University of Michigan, Dean of the Medical School, and CEO of Michigan Medicine. Prior to joining the University of Michigan in March 2015, he was executive dean and chair of the UNC Department of Medicine, where he was instrumental in guiding the academic and clinical leadership of the School of Medicine and the UNC Health Care System. He was also principal investigator and director of the North Carolina Translational and Clinical Sciences (NC TraCS) Institute at UNC-Chapel Hill.
Dr. Runge has been a physician-scientist for his entire career, combining basic and translational research with the care of patients with cardiovascular diseases and education. He is the author of over 200 publications in the field and holds five patents for novel approaches to health care.
This is the inaugural Laurence E. Earley lecture, honoring Dr. Earley (1931-2012), an internationally known nephrologist who retired from UNC in 2000.

Medicine Grand Rounds, Eric Edwards and Michael Craig, "Best of 2017: An Update in Hospital Medicine"
2018-04-12 12:00 - 13:00
Drs. Craig and Edwards will be reviewing the highlights of the latest medical literature pertaining to the practice of hospital medicine. Specific topics include updated guidelines on the treatment of C. difficile colitis, DOACs for cancer-associated VTE, and many more. The speakers note that the lecture will be fast-paced, interactive, and (hopefully) fun!
Eric Edwards is Associate Chief for Clinical Operations at Hillsborough, and Associate Professor of Medicine and Pediatrics.
Michael Craig is Associate Chief for Clinical Operations at Chapel Hill and Associate Professor of Medicine.

McAllister Heart Institute Seminar Series: Rong Tian, MD, PhD, “Metabolic Modulation of Cardiac Remodeling”
2018-04-10 14:00 - 15:00
Speaker: Rong Tian, MD, PhD, Professor of Anesthesiology and Pain Medicine, Director of the Mitochondria and Metabolism Center, University of WashingtonTopic: “Metabolic Modulation of Cardiac Remodeling”

Cardiovascular Grand Rounds : Andrew Doorey, MD, "A Failure to Communicate: Safety Gaps in the Cardiac Catheterization Lab"
2018-04-09 12:00 - 13:00
Speaker: Andrew Doorey, MD, Cardiologist, Christiana Care Health System in Wilmington, DelawareTopic: “A Failure to Communicate: Safety Gaps in the Cardiac Catheterization Lab”

Medicine Grand Rounds, Nigel Key "Hemophilia, A 100-Year Story"
2018-04-05 12:00 - 13:00
Although it’s been nearly a century since hemophilia was considered an early death sentence, treating it can be time-consuming and troublesome. Many people with the blood disease give themselves frequent drug infusions to keep their condition under control, sometimes as often as several times a week.
Several newly approved medications, while far from a cure, aim to lift some of that burden. Some will allow patients to go longer between treatments. Another drug in development aims to overcome a problem with current treatments, which can sometimes stop working for people whose bodies become resistant to them.
“There’s never been a time when the pipeline is as full as it is now,” says Nigel Key, MB, ChB, a hematologist and director of the UNC Hemophilia and Thrombosis Center. “I think it’s a reflection of the ability of biotechnology to bring these things forward.”
Dr. Key is Vice Chief of the Division of Hematology/Oncology. His practice is limited to patients with non-malignant blood disorders. His particular interests are in bleeding and clotting disorders.

McAllister Heart Institute Seminar Series: Xander Wehrens, MD, PhD, "Remodeling of calcium release unit proteins in Heart Failure"
2018-04-03 14:00 - 15:00
Speaker: Xander Wehrens, MD, PhD, Professor, Director of Cardiovascular Research Institute, Baylor University Topic: “Remodeling of calcium release unit proteins in Heart Failure”

Medicine Grand Rounds, James Evans, "Precision Medicine in the Clinic and in Public Health -- A Genomic Perspective"
2018-03-29 12:00 - 13:00
Dr. Evans will discuss the realistic uses of massively parallel sequencing, including genome scale sequencing, in clinical medicine and public health.
Jim Evans, MD, PhD, is the Bryson Distinguished Professor of Genetics and Medicine at The University of North Carolina at Chapel Hill. He directs Adult and Cancer Genetics Services and is clinically active in Medical Genetics and General Internal Medicine. He is Editor in Chief of Genetics in Medicine, the preeminent clinically focused Medical Genetics Journal and the official journal of The American College of Genetics and Genomics.

McAllister Seminar Series: Kenneth Walsh, PhD
2018-03-27 14:00 - 15:00
Speaker: Kenneth Walsh, PhD, Lockhart B. McGuire Professor, Director of Hematovascular Biology Center, University of VirginiaTopic: “Clonal Hematopoiesis and Cardiovascular Disease: New Mechanisms, New Therapeutic Opportunities”
