Medicine Grand Rounds: Point/Counterpoint: Raj Kasthuri and Joseph Rossi, Catheter-Directed Therapies for Acute Pulmonary Embolism
2018-11-15 12:00 - 13:00 (America/New_York)

Medicine Grand Rounds, Point/Counterpoint: Raj Kasthuri and Joseph Rossi "Catheter-Directed Therapies for Acute Pulmonary Embolism"
2018-11-15 12:00 - 13:00
Dr. Raj Kasthuri is Assistant Professor of Medicine in the Division of Hematology and Oncology and is the Director of the UNC HHT Center of Excellence. He is a member of the UNC Hemophilia and Thrombosis Center and the UNC McAllister Heart Institute. Dr. Kasthuri’s clinical and research interests are in bleeding and clotting disorders, and HHT.
Dr. Joseph Rossi is Associate Professor of Medicine, Director of the Cardiac Catheterization Lab, Program Director of the Interventional Cardiology Fellowship, and Co-Director of Cardiology Clinical Trials. He specializes in interventional cardiology.

Department of Medicine Faculty Meeting
2018-11-08 12:00 - 13:00
Dr. Ron Falk, Chair of the Department of Medicine, will provide updates on the department. Dr. Wesley Burks, Executive Dean of the School of Medicine, also will make a presentation. This meeting replaces Medicine Grand Rounds and is for faculty, fellows and residents. A boxed lunch will be served.
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McAllister Heart Institute Seminar Series: Dr. Matthias Nahrendorf,“Myeloid cells in cardiovascular disease”
2018-11-07 10:00 - 11:00
Speaker: Dr. Matthias Nahrendorf, Professor, Center for Systems Biology, Harvard UniversityTopic: Myeloid cells in cardiovascular disease

Cardiovascular Grand Rounds: Dr. Gregory Sprung
2018-11-05 12:00 - 13:00
Speaker, Gregory Sprung, MD, UNC Cardiology Fellow

Medicine Grand Rounds, David Weber "Vaccines: New ACIP Recommendations and Rationale"
2018-11-01 12:00 - 13:00
Through his roles as medical director of hospital epidemiology and associate chief medical officer of UNC Health Care, Dr. Weber works to prevent hospital-acquired infections in patients and staff at UNC Hospitals.
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Medicine Grand Rounds, Nicholas Shaheen "PPI Therapy: Is the Risk Worth the Benefit?"
2018-10-25 12:00 - 13:00
The internet is rife with warnings about the side effects of acid suppressants. With millions of people taking these drugs, new reports about dementia, kidney damage, bone fracture and other putative side effects cause much concern for patients and providers. But how much of it is true? And what should we do about it? The goals of this lecture are to review the possible side effects of acid suppressants, to provide a framework for understanding the convoluted literature on PPI side effects, and to give some practical guidance for advising your patients regarding the use of acid suppressants.
Dr. Shaheen is Chief of the Division of Gastroenterology and Hepatology. He has performed extensive clinical and translational research in diseases of the esophagus, include GERD, Barrett’s esophagus and esophageal cancer. He has authored over 300 articles on these diseases, including national guidelines for the care of patients with GERD and Barrett’s esophagus.
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Cardiovascular Grand Rounds: Dr. Robert Rayson, “Percutaneous Mechanical Support in STEMI: Options, Patient Selection & Future Directions"
2018-10-22 12:00 - 13:00
Speaker: Robert Rayson, MD, UNC Cardiology FellowTopic: “Percutaneous Mechanical Support in STEMI: Options, Patient Selection & Future Directions”

Echocardiography Before & After TAVR: Assessment of Aortic Valve Disease
2018-10-20 08:00 - 12:00
A Satellite Symposium at the North Carolina Cardiovascular Update
YOU’RE INVITEDThe UNC Center for Heart & Vascular Care is pleased to present an Echo Satellite Symposium at the 2018 North Carolina Cardiovascular Update.1. Enhance sonographers’ clinical knowledge of the prevalence, incidence, prognosis and progression of aortic stenosis (AS).2. Enhance sonographers’ clinical knowledge of the pathophysiology of AS.3. Improve ability to detect hemodynamic progression of AS by Doppler echocardiography.4. Gain a solid understanding of the classification and determination of severity as it pertains to AS.5. Introduce sonographers’ to the proper assessment of AS through live hands on simulation.
CREDIT DESIGNATIONThe American Society of Echocardiography (ASE) will be providing 4.0 ASE CEU’s for this conference. These credits are accepted by the American Registry for Diagnostic Medical Sonography (ARDMS) and Cardiovascular Credentialing International (CCI).
Register here or download our brochure, which includes a registration form.

2018 North Carolina Cardiovascular Update
2018-10-19 13:00 - 2018-10-20 18:00
Target Audience
Cardiologists, cardiac surgeons, internists, family practice and primary care physicians, emergency physicians, nurses, nurse practitioners, physician assistants, and other health professionals involved in the treatment of cardiovascular disease
Objectives
Identify and integrate various state-of-the art treatments for cardiovascular disease utilized by primary care physicians and cardiologists, including percutaneous and surgical therapies
Review state-of-the-art diagnostic techniques and imaging options for assessing patients with cardiovascular disease
Review important clinical trials in cardiology that have been completed within the past year, including but not limited to cholesterol-lowering drugs, and apply the information learned to daily practice

Register here or download our brochure, which includes a registration form.

Medicine Grand Rounds Ernest and Hazel Craige Lecture, Patrick O'Gara "Infective Endocarditis"
2018-10-18 12:00 - 13:00
Patrick T. O’Gara, MD, is the Director of Strategic Planning for the Cardiovascular Division at Brigham and Women’s Hospital, and the Watkins Family Distinguished Chair in Cardiology and Professor of Medicine at Harvard Medical School. His clinical activities are focused on patients with valvular heart disease, other structural heart diseases and aortic diseases, although he also maintains a large practice of general cardiology. Since 2001, he has been named annually among the Top Doctors in Boston and the U.S.
Dr. O’Gara is presenting the annual Ernest and Hazel Craige lecture which honors Dr. Ernest Craige, the first chief of the UNC Division of Cardiology, who served from 1952 until 1978.
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McAllister Heart Institute Seminar Series: Dr. Lena Claesson-Walsh
2018-10-12 10:00 - 2018-10-13 11:00
Speaker: Dr. Lena Claesson-Walsh, Uppsala University

Medicine Grand Rounds, Gary Jay "Minor Traumatic Brain Injury, Chronic Traumatic Encephalopathy and Post Traumatic Headaches"
2018-10-11 12:00 - 13:00
Dr. Jay will discuss the diagnosis and pathophysiology of minor Traumatic Brain Injury, along with Chronic Traumatic Encephalopathy. He also will describe the most common forms of Post-Traumatic Headache, including diagnosis and treatment.
Gary Jay specializes in the diagnosis and treatment of headache and pain of all types including migraine with and without aura, chronic daily headaches, tension-type headaches (episodic and chronic), medication overuse headaches, cluster headache and other trigeminal autonomic cephalalgias. His research interests include analgesic drug development. Dr. Jay is a professor in the UNC Department of Neurology.
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McAllister Seminar Series: Dr. Brian Kim
2018-10-10 10:00 - 11:00
Speaker: Dr. Brian Kim, Stanford University

Medicine Grand Rounds, Katya Rubinow "Can Sex Steroids Help Elucidate the Utility of HDL As an Index of Cardiovascular Risk?"
2018-10-04 12:00 - 13:00
In epidemiologic studies, sex steroid deficiency predicts cardiovascular risk in both men and women, but the utility of hormone replacement therapy for reducing cardiovascular risk remains uncertain. Exogenous sex steroids regulate plasma concentrations of high-density lipoprotein cholesterol (HDL-C), but little is known about sex steroid-mediated effects on other metrics of HDL composition and function. Understanding the roles of sex steroids in regulating the function and composition of HDL particles may lend new insight into the cardioprotective potential of hormone replacement therapy and, further, may help elucidate the utility of HDL-based metrics for predicting cardiovascular risk on an individual basis.
Katya Rubinow, MD, is a board-certified physician at the Endocrinology/Diabetes Clinic at Harborview and a University of Washington assistant professor of Medicine and Metabolism, Endocrinology and Nutrition. Dr. Rubinow cares for patients with diabetes, thyroid disease and a broad spectrum of other endocrine disorders. She strives to help patients feel supported and understood and to provide information that will enable them to be powerful advocates for their own health.
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Medicine Grand Rounds, Christine Sinsky "Joy in Medicine"
2018-09-27 12:00 - 13:00
Professional satisfaction is a powerful driver of patient experience, quality of care and wise resource use. Burnout is widespread among physicians and is the result of health system dysfunctions, rather than weakness on the part of individuals. Improvements in clinical workflow, teamwork and leadership are among the most potent anecdotes to the burnout. This session will describe approaches that institutions and individual practices can take reduce burnout and improve the joy, purpose and meaning in work for health professionals.
Christine Sinsky, MD, is the vice president of professional satisfaction at the American Medical Association. She is also a practicing internist in Dubuque, Iowa, and the Chair of the American Board of Internal Medicine Foundation. A frequent invited lecturer on practice innovation, redesign and physician satisfaction, Dr. Sinsky has presented widely, both nationally and internationally.
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McAllister Heart Institute Seminar Series: Dr. Anne Marie Schmidt, "Rage/Diaph1 Mechanism of Diabetic Complications and Metabolic Dysfunction"
2018-09-26 10:00 - 11:00
Speaker: Dr. Anne Marie Schmidt, New York UniversitySubject: Rage/Diaph1 Mechanism of Diabetic Complications and Metabolic Dysfunction

Cardiovascular Grand Rounds: Dr. Bo Jiang, "Genetics of Coronary Artery Disease"
2018-09-24 12:00 - 13:00
Speaker: Bo Jiang, MD, UNC Cardiology FellowTopic: Genetics of Coronary Artery Disease

Medicine Grand Rounds, Todd Baron and Ian Grimm "Recent Advances in Therapeutic Endoscopy"
2018-09-20 12:00 - 13:00
Once deemed primarily diagnostic, endoscopy has quickly transcended to a minimally invasive intervention and therapeutic tool. This continuous evolution of the spectrum of endoscopy represents an active area of ongoing research and clinical care with tremendous biomedical potential. This review will focus on latest developments in the field of therapeutic endoscopy
Ian Grimm, MD, has been practicing advanced therapeutic gastrointestinal endoscopy for nearly 30 years and has had a longstanding interest in the non-surgical removal of complex polyps. In 2016, he undertook a sabbatical to study endoscopic submucosal dissection and per-oral endoscopic myotomy in Japan, where these techniques were initially developed. Dr. Grimm has served as director of the GI Procedures unit at UNC Memorial Hospital since 2000.
Todd Baron, MD, performs endoscopic treatment of complex gastrointestinal disorders, particularly management of pancreaticobiliary obstruction through the use of endoscopic retrograde cholangiopancreatography and endoscopic ultrasound. He also conducts extensive clinical research in endoscopic management of diseases throughout the gastrointestinal tract. Dr. Baron is Director of Advanced Therapeutic Endoscopy at UNC.
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Department of Medicine Faculty Meeting CANCELLED
2018-09-13 12:00 - 13:00

Cardiovascular Grand Rounds: Dr. Cory Henderson, “Cardiac CT: A Review of Clinical Applications"
2018-09-10 12:00 - 13:00
Speaker: Cory Henderson, UNC Cardiology FellowTopic: Cardiac CT: A Review of Clinical Applications

Medicine Grand Rounds, Ria Dancel "POCUS: Power and Pitfalls"
2018-06-14 12:00 - 13:00
Dr. Ria Dancel
Ria Dancel specializes in the care of hospitalized adults and children, bedside ultrasound at the point of care, ultrasound guided procedures, resident education. Dr. Dancel’s area of clinical interest and quality improvement research focuses on point of care ultrasound (POCUS) as a diagnostic tool and an instrument to increase patient safety during invasive bedside procedures.
Dr. Dancel is Director of the Medicine Procedure Service, and Associate Chief of Education and Faculty Development in the Division of Hospital Medicine. She is an associate professor in the Departments of Internal Medicine and Pediatrics.

Medicine Grand Rounds, Richard Boucher "Muco-Obstructive Lung Diseases: Mucus Concentration and Relationship to Bronchitis"
2018-06-07 12:00 - 13:00
Richard Boucher is James C. Moeser Eminent Professor of Medicine and Director of Marsico Lung Institute. Dr. Boucher’s lab has focused on the normal physiology of airway surface liquids (ASL) and how this system fails in airways diseases, e.g., cystic fibrosis and COPD. The lab pursues a variety of investigations into the functions of airway epithelia in health and disease.

Medicine Grand Rounds, Saira Sheikh “BAFFling New Lupus Therapies – Looking to the Future After Decades of Failed Clinical Trials”
2018-05-31 12:00 - 13:00
Systemic lupus erythematosus (SLE) is a chronic, debilitating autoimmune disease with heterogeneous manifestations ranging from scarring skin rash or arthritis to severe, organ-threatening involvement of the kidneys, heart, lungs or central nervous system. SLE is characterized by the presence of autoantibodies against nuclear antigens, which are thought to be caused by dysregulation of the immune system. Development of new therapies is critical due to unmet needs associated with SLE, including inadequate disease control, poor health-related quality of life, medication toxicities and increased morbidity and mortality.
One challenge in caring for patients with SLE is a lack of approved and efficacious medications. Randomized controlled trials evaluating novel biologic immune modulators in SLE have been largely unsuccessful at achieving the primary endpoints needed for FDA approval. Efforts to develop therapies against specific molecular targets in SLE has resulted in the identification of BAFF (B-cell activating factor) inhibitors to treat the disease. This talk will provide a summary of that journey and a brief overview of what’s on the horizon for SLE therapies.
Dr. Saira Sheikh is an Assistant Professor of Medicine, Director of Clinical Trials Program at the UNC Thurston Arthritis Research Center and Director of the UNC Rheumatology Lupus Clinic. Dr. Sheikh’s work has been focused on building a Collaborative Lupus Clinical & Research Program that directly impacts the care of patients. She is working on a national level to develop programs that address racial disparities in lupus clinical trials.

Medicine Grand Rounds, Tony Mazzella, Rosanne Tiller, Russell Coletti, and Alyssa Tilly, "Chief Resident Year in Review"
2018-05-24 12:00 - 13:00
Tony Mazzella and Rosanne Tiller will present Multidisciplinary Bedside Rounds, their project to restructure rounds with a consistent multidisciplinary team presence at the patients’ bedsides to have a clinical discussion with the most important team member: the patient.
Alyssa Tilly will discuss the Professional Development Coaching Program, a modality to promote resilience and combat burnout by allowing those who are being coached to self-identify positive individual traits and experiences.
Russell Coletti will present Expected Practices Tool, a quality improvement measure to enhance the initial care of patients with Rheumatoid Arthritis. This tool can be expanded to other medical conditions, improving patient care by fostering collaboration between primary care and specialty practices.

McAllister Heart Institute Seminar Series: David Zawieja, PhD, "Lymphatics: the link between the parenchyma, cardiovascular and immune systems"
2018-05-22 14:00 - 15:00
Speaker: David Zawieja, PhD, Regents Professor and Department Head of Medical Physiology, Texas A&M University College of MedicineTopic: Lymphatics: the link between the parenchyma, cardiovascular and immune systems

Medicine Grand Rounds, Sascha Tuchman and Koyal Jain, "Amyloidosis, Cyanide, Myeloma and Ethanol: Conceptualizing Renal Diseases Caused by Monoclonal Gammopathies"
2018-05-17 12:00 - 13:00
Monoclonal gammopathies are a group of plasma cell or B-cell disorders including true cancers such as multiple myeloma or “sort-of cancers” such as light chain amyloidosis. These disorders in many cases cause no injury to a person (i.e., monoclonal gammopathy of undetermined significance [MGUS]) but when they do cause injury, the pattern of injury can be quite varied and often includes the kidneys. Monoclonal gammopathy of renal significance (MGRS) is a recently described category of nephrotroxic monoclonal gammopathies that arise in the absence of an overt hematologic malignancy. Monoclonal gammopathies overall have been increasingly recognized as a cause of renal failure. Over 660,000 Americans have kidney failure, and early recognition of the etiology of kidney disease can prevent progression to end-stage kidney disease through aggressive interventions, such as chemotherapy in proven cases of multiple myeloma or MGRS. The management of these patients requires close collaboration between nephrologists and oncologists. In this presentation, we will be focusing on the wide spectrum of diseases associated with nephrotoxic plasma cell disorders, with a focus on how to conceptualize them clinically.
Sascha Tuchman is a UNC Comprehensive Cancer Center member and Associate Professor of Medicine. Dr. Tuchman’s research has a special focus on amyloidosis and multiple myeloma.
Koyal Jain is an Assistant Professor of Medicine in the Nephrology division. She specializes in acute kidney injury and chronic kidney disease, dialysis management, high blood pressure management, abnormalities of electrolytes like sodium, potassium, calcium, and glomerular diseases.

Medicine Grand Rounds, Steven Russell "The Bionic Pancreas"
2018-05-10 12:00 - 13:00
The bionic pancreas system proved better than either conventional or sensor-augmented insulin pump therapy at managing blood sugar levels in patients with type 1 diabetes living at home, with no restrictions, over 11 days. “For study participants living at home without limitations on their activity and diet, the bionic pancreas successfully reduced average blood glucose, while at the same time decreasing the risk of hypoglycemia,” says Steven Russell. “This system requires no information other than the patient’s body weight to start, so it will require much less time and effort by health care providers to initiate treatment. And since no carbohydrate counting is required, it significantly reduces the burden on patients associated with diabetes management.”
Since 2006 Steven Russell has collaborated on this project with Dr. Edward Damiano, a Biomedical Engineer at Boston University. The trials are scheduled to begin in the fourth quarter of 2018.

Cardiovascular Grand Rounds: Olga Bokeriya, MD, PhD, FACC, "The Russian National Center for Cardiology and Cardiovascular Surgery: Extensive Experience and Creative Innovations"
2018-05-07 12:00 - 13:00
Speaker: Olga Bokeriya, MD, PhD, FACC, Professor of Cardiology; Chief, Department of Cardiac Surgery; Chief Scientist and Physician for Bakoulev National Medical and Research Center for Cardiovascular Surgery and Ministry for Healthcare, Russian Federation in MoscowTopic: “The Russian National Center for Cardiology and Cardiovascular Surgery: Extensive Experience and Creative Innovations”

Medicine Grand Rounds Blythe Lecture, Mark Zeidel "Salt and Water, Not So Simple"
2018-05-03 12:00 - 13:00
Dr. Blythe was an expert in salt and water homeostasis. This lecture will use a case-based approach to review the overall principles of salt and water homeostasis, and will describe new paradigms in long term salt balance, the storage of salt in the tissues and the neural control of salt appetite and thirst. Future advances in salt and water homeostasis will enhance the therapy of hypertension and shock, as well as disorders of water metabolism.
Dr. Mark Zeidel is Herrman L. Blumgart Professor of Medicine at Harvard Medical School, and Chair and Physician-in-Chief at Beth Israel Deaconess Medical Center in Boston. His research has been recognized by the American Physiological Society, the American Society for Clinical Investigation and the Association of American Physicians. His research has received continuous funding by the NIH for more than 30 years.
Every one to three years, the Division of Nephrology and Kidney Center invites a lecturer to honor the memory of Dr. William Blythe, II. Dr. Blythe, the first Division Chief for Nephrology and Hypertension at UNC, was an outstanding physician-scientist and teacher who inspired many of us to pursue nephrology. He was also a gifted man of letters.
