DOM Medicine Grand Rounds- Dr. Brian Jensen & Jo Ellen Rodgers, PharmD presents: Cardio-Oncology: 2025 Update
2025-12-11 12:00 - 13:00 (America/New_York) | NC

DOM Medicine Grand Rounds- Dr. Barbara LeVarge presents: From Mystery to Mechanism: Invasive CPET in the Evaluation of Exertional Dyspnea."
2025-12-04 12:00 - 13:00 | Room 4008 Old Clinic Auditorium, Chapel Hill, NC, United States
Dr. Barbara LeVarge is a clinical associate professor within the division of Pulmonary and Critical Care Medicine at UNC. Dr. LeVarge serves as the Associate Director of the Pulmonary Hypertension Program as well as the Medical Director of Pulmonary Diagnostics (Pulmonary Function Lab). She is a pulmonary vascular disease specialist with clinical focus on the treatment of patients with pulmonary arterial hypertension, chronic pulmonary embolism, and sickle cell related lung disease. She has additional clinical and research interests in the use of exercise testing and invasive hemodynamics in a variety of cardiopulmonary diseases.

DOM Medicine Grand Rounds- Jason Mock presents: "Translating the Nobel: Regulatory T Cells in Medicine.
2025-11-20 12:00 - 13:00 | Room 4008 Old Clinic Auditorium, Chapel Hill, NC, United States

DOM Medicine Grand Rounds- Dr. Hyman B. Muss presents: "How To Become The Best Doctor You Always Wanted To Be- Caring For Older Patients With Cancer."
2025-11-06 12:00 - 13:00 | Room 4008 Old Clinic Auditorium, Chapel Hill, NC, United States

DOM Medicine Grand Rounds- Dr. David Wohl presents: "How Internists Will End the U.S. HIV Epidemic"
2025-10-30 12:00 - 13:00 | Room 4008 Old Clinic Auditorium, Chapel Hill, NC, United States

DOM Medicine Grand Rounds- "2025 Craige Lecture" Dr. Robert Harrington presents: "35 Years of RCT's: Lessons Learned"
2025-10-09 12:00 - 13:00 | Room 4008 Old Clinic Auditorium, Chapel Hill, NC, United States
Dr. Robert A. Harrington is a cardiologist and serves as the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine and Provost for Medical Affairs of Cornell University. His research areas of focus include evaluating antithrombotic therapies to treat acute ischemic heart disease and to minimize the acute complications of percutaneous coronary procedures and trying to better understand and improve upon the methodology of clinical research, including the use of technologies to facilitate the conduct of clinical trials. A previous American Heart Association (AHA) president, Dr. Harrington remains a member of AHA’s Board of Directors. He is also an elected member of the Association of American Physicians, the Association of University Cardiologists, and the National Academy of Medicine. In addition, he has served as a chair and member of the US Food and Drug Administration Cardiovascular and Renal Drugs Advisory Committee. Among his numerous awards and recognition, Dr. Harrington was named a Master of the American College of Cardiology in 2016, was awarded the AHA’s Clinical Research Prize in 2017, and earned the AHA Council on Clinical Cardiology (CLCD) Distinguished Achievement Award in 2022. In 2022, he was awarded the Stokes Medal, and in 2023, Honorary Fellowship in the Irish Cardiac Society. From the AHA he received both the 2024 Chairman’s Award and the Gold Heart Award for his leadership. The Cardiovascular Research Foundation recognized him with the 2024 TCT (Transcatheter Cardiovascular Therapeutics) Career Achievement Award as an outstanding individual who has made extraordinary contributions to the field of interventional cardiology and made a transformative impact on cardiovascular care through clinical excellence, pioneering research and mentorship

DOM Medicine Grand Rounds- Dr. Hanna Sanoff presents: "Advances in Colorectal Cancer"
2025-10-02 12:00 - 13:00 | Room 4008 Old Clinic Auditorium, Chapel Hill, NC, United States

DOM Medicine Grand Rounds- Dr. Seth Berkowitz presents: "Understanding Food is Medicine Interventions"
2025-09-25 12:00 - 13:00 | Room 4008 Old Clinic Auditorium, Chapel Hill, NC, United States

DOM Medicine Grand Rounds- Chair, Dr. Darren DeWalt presents: "What's Important for the UNC Department of Medicine in 2025"
2025-09-11 12:00 - 13:00 | Room 4008 Old Clinic Auditorium, Chapel Hill, NC, United States

DOM Grand Rounds- Dr. Brian T. Klausner presents: "Better Understanding the Expensive Suffering of Chronic Homelessness in the Evolving World of Value-Based Care"
2025-06-12 12:00 - 13:00 | NC
Dr. Brian Klausner has spent his career advocating for patients and driving quality improvement. He joined WakeMed Primary Care in 2011 after working for Boston Health Care for the Homeless Program as the medical director of their Boston Medical Center outpatient clinic.
Dr. Klausner serves as Medical Director for WakeMed’s Community Population Health program, which works to improve the health of uninsured and homeless patient populations. As medical director, he drives collaboration with community partners to ensure patients are connected with a medical home and get the resources they need, whether it is blood pressure medication, counseling, housing or legal assistance. He also serves as Chief Medical Officer of WakeMed Key Community Care, where he advocates for enhancing the quality and coordination of care while reducing costs.
Dr. Klausner earned his medical degree from Georgetown University School of Medicine and completed his internal medicine residency at University of Chicago Hospitals. He was recognized as a 2017 Health Care Hero by the Triangle Business Journal and received the 2019 T. Reginald Harris Award, awarded each year by the North Carolina Medical Society to a physicians with outstanding achievements in health care quality and service to the medical community.

DOM Grand Rounds- Dr. Rick Stouffer, Dr. Alan Hinderliter, & Dr. Raven Voora presents: "Lifestyle modification, medications, or renal denervation- Which is the optimal treatment for resistant hypertension? A Debate"
2025-06-05 12:00 - 13:00 | Room 4008 Old Clinic Auditorium, Chapel Hill, NC, United States
George (Rick) Stouffer, MD is the Ernest and Hazel Craige Distinguished Professor of Medicine and Professor of Biomedical Engineering and serves as the Chief of Cardiology, Physician in Chief of the Heart and Vascular Service Line and Co-Director of the McAllister Heart Institute. He is an interventional cardiologist with basic science research interests in atherosclerosis and smooth muscle cell growth regulation and clinical research interests in precision medicine for cardiology, renal denervation, renal artery stenosis and disparities in access to cardiovascular care.

Alan Hinderliter is a Professor of Medicine in the Division of Cardiology at the University of North Carolina. His principal clinical interests are hypertension, echocardiography, valvular heart disease, and preventive cardiology. He is a hypertension specialist and sees patients with high blood pressure that is difficult to control in the multidisciplinary UNC Hypertension Clinic. He also serves as the medical director of the UNC Hospitals echocardiography laboratory. His research has focused on the effects of exercise, diet, and weight loss on high blood pressure, novel therapies for resistant hypertension, and the relationships of high blood pressure to cardiovascular structure and function.

Dr Raven Voora is a Clinical Associate Professor of Medicine in the Division of Nephrology and Hypertension at the University of North Carolina Chapel Hill. She completed her Nephrology Fellowship training at the University of Pennsylvania. While at UNC, she helped to develop the UNC Hypertension Clinic which has been certified by the AHA as a Hypertension Center of Excellence. In addition to work in hypertension, Dr Voora is the Associate Program Director for the Nephrology Fellowship Training Program.

DOM Grand Rounds- Dr. Samuel C. Durso presents: "Trust- Reflections and Lessons on the Topic."
2025-05-29 12:00 - 13:00 | Room 4008 Old Clinic Auditorium, Chapel Hill, NC, United States
Graduated with honors from Baylor College of Medicine in 1978, Internship and Residency in Internal Medicine at the University of Alabama Teaching Hospitals (1979 – 1981), Masters of Business Administration from the Johns Hopkins Carey Business School in 2007.
Private practice of Internal Medicine in Columbia, SC until joining faculty in the Division of Geriatric Medicine and Gerontology in 1995. Clinical concentration on caring for older adults with complex health needs in the office and hospital settings. Academic concentration on teaching, program development in education and clinical care.
Roles in the Division included Fellowship Program Director (2003 – 2006), Clinical Director and Director of Education (2004 – 2008), Interim Director of the Division (2008 – 2009) and Director, Division of Geriatric Medicine and Gerontology.
In 2020 became Executive Vice Chair for the Department of Medicine, Johns Hopkins University, and 2021 Director of the Department of Medicine for the Johns Hopkins Bayview Medical Center, both positions he holds currently.

DOM Grand Rounds- '24-'25 Chief Residents presents: Chief Grand Rounds-"Friends Edition"
2025-05-22 12:00 - 13:00 | Room 4008 Old Clinic Auditorium, Chapel Hill, NC, United States
Inpatient Chief: Jacob Amburn, MD
Jacob Amburn grew up in a military family and moved around the country throughout his childhood. He graduated with a degree in Biochemistry, Cellular, and Molecular Biology from the University of Tennessee, Knoxville and took his talents across the state of Tennessee to the University of Tennessee Health Science Center in Memphis for medical school before making his way to Chapel Hill for residency. Here he has found a passion for oncology and teaching, and after his chief year, he plans to pursue a fellowship in hematology and oncology and continue on in a career in academic medicine with an emphasis on medical education. His wife is a chief resident in Emergency Medicine at Duke, and when not in the hospital they enjoy exploring all of the restaurants the Triangle has to offer, having recently enjoyed their 100th unique restaurant in the area.

Medicine-Pediatrics Chief: Emma Bick, MD
Emma Bick is a Chapel Hill native and life long Tar Heel fan. She attended Williams College where she majored in Mathematics with a minor in Public Health before returning to UNC for her MD and MPH. While at UNC she was very involved in the student run free clinic (SHAC). She decided to stay at UNC for residency, drawn to its strong Med-Peds tradition and amazing Med-Peds faculty as well as the supportive and inclusive community. She is delighted to give back to the program and follow in the footsteps of the former med peds chiefs whom she admires so much. Following training, Emma plans to pursue a fellowship in Adult Pulmonology and Critical Care. In her free time she enjoys spending time outdoors with her corgi, Alis, hosting dinner parties, and taking day trips to the beach.

Outpatient Chief: Christopher Lee, MD
Christopher Lee is from Indianapolis, IN and attended Wheaton College, where he majored in both Spanish and Applied Health Science. He graduated from the Indiana University School of Medicine prior to moving to North Carolina to compete his residency in Internal Medicine and now serves as the Ambulatory Chief Resident for the program. Following his chief residency year, he plans to pursue a fellowship in gastroenterology and plans to remain active in medical education and research. In his free time, he is an avid runner and enjoys other hobbies such as fly fishing, hiking, photography, cooking, and traveling.
Inpatient Chief: Portia Nleya, MD
Portia Nleya was born in Bulawayo, Zimbabwe, but moved to the United States when she was eight. Portia has spent most of her life in North Carolina. She attended UNC for college, where she studied Biology, and later earned a Master of Public Health with a concentration in Epidemiology at IU-Bloomington. Before returning to UNC for medical school, Portia worked as a public health advisor for the CDC in Richmond, Virginia, focusing on community outreach and immigrant health. Portia was excited to match at UNC for her Internal Medicine Residency, making her a triple Tar Heel. She looks forward to her role as inpatient chief, engaging in education at all levels and fostering an open environment. After her chief year, Portia plans to continue her career in academic primary care, with a focus on being a clinician-educator. In her free time, she enjoys board games, playing the guitar, videography, and is an avid film enthusiast.
WakeMed Chief: Ryan Searcy, MD
Ryan Searcy grew up in North Carolina where he later attended UNC and received his bachelor’s in biology. He loved Chapel Hill and everything the Triangle has to offer, leading him to stay at UNC for medical school, where he was inducted into the AOA Honor Society and was active in student government. He solidified his status as a tarheel “Lifer” when he decided to stay at UNC for residency, drawn to the resident-led culture and focus on quality patient care above all else. He is excited to be continuing his journey at UNC this year as the Wake Med Chief in Raleigh. During his free time, Ryan enjoys traveling, trying new restaurants around the Triangle, and watching Carolina sports (Go Heels!).

DOM Grand Rounds- Dr. Stergios Moschos & Dr. David Ollila presents: " Do NOT Throw the Baby Out with the Bath Water"
2025-05-15 12:00 - 13:00 | Room 4008 Old Clinic Auditorium, Chapel Hill, NC, United States
Stergios Moschos, MD, has a research focus on identifying molecules that are important for melanoma development and progression, identifying mechanisms of action of FDA-approved and investigational agents in melanoma.
For example, he identified that Ubc9, the single SUMO E2 conjugating enzyme is highly expressed in melanoma-infiltrated lymph nodes and that targeting Ubc9 in melanoma cell lines enhances the cytotoxic effect of chemotherapeutic agents. Furthermore, he studied the mechanism of action of high-dose interferon as part of a neoadjuvant trial in patients with stage III melanoma.

David Ollila, MD, is a general surgical oncologist with broad training in all aspects of surgical oncology. His special areas of interest are in melanoma, breast cancer, and the surgical management of endocrine disorders, with a focus on providing a translational step for basic scientists between the laboratory and the clinic. During his training at John Wayne Cancer Institute, Ollila became very familiar with the polyvalent melanoma vaccines being studied there. At UNC, he has initiated two vaccine clinical trials that will lead to further immunotherapy research and clinical applications in this area. Ollila is planning collaborative work on melanoma sentinel nodes in an epidemiology study being run by the UNC School of Public Health.
Ollila’s breast cancer research interests include work derived from his expertise in sentinel node biopsy, a technique for identifying the lymph node most likely to contain cancer metastasis. He was one of the first to examine the use of sentinel lymph node biopsy as a method to improve the ability to determine tumor extent and minimize surgery in women undergoing neoadjuvant, or preoperative, chemotherapy. He has also developed a method using a new technique for identifying cancer, positron emission tomography (PET) to help guide surgery after chemotherapy. This method is being tested in an ongoing clinical trial.

DOM Grand Rounds- Dr. Josh Berkowitz & Dr. Stephan Moll presents: "Athletes and Venous Thromboembolism"
2025-05-08 12:00 - 13:00 | NC
Dr. Josh Berkowitz is an Associate Professor of Orthopaedics, Internal Medicine and Pediatrics and Chief of the Division of Nonoperative Sports and Musculoskeletal Medicine. He serves as a Team Physician for the Tar Heels, with primary responsibilities for Football, Women’s Basketball, Men’s Lacrosse and Men’s and Women’s Swimming and Diving while providing point-of-care ultrasound diagnostics and procedural intervention to student-athletes from all 28 athletics programs. In addition to covering dozens of NCAA competitions annually, Dr. Berkowitz serves as Team Physician for Chapel Hill High School, two local professional ultimate teams, and as an Event Physician for the National Basketball Association, providing event coverage locally, nationally and internationally including NCAA Championships, NBA All-Star and Basketball without Borders. In addition to anticoagulation in athletes, Dr. Berkowitz’s professional interests include patient care, event coverage, and advancing minimally-invasive management of musculoskeletal conditions.

Dr. Stephan Moll received his medical degree from Freiburg University, Germany, including a one year of clinical training in London (Hammersmith Hospital and Institute of Neurology at Queens Square), and performed a pathology residency at the Institute of Pathology, University of Aachen, Germany. He completed a residency and fellowship in Internal Medicine and a Hematology-Oncology at Duke, and a one-year Clinical Coagulation fellowship at UNC; he then worked as a coagulationist in the cardiology division of Humboldt University in Berlin, Germany. He has been at UNC as a faculty member in the Department of Medicine and the Division of Hematology since 1999.

His clinical focus is coagulation, particularly thrombosis, thrombophilia and anticoagulation, and his research interests include clinical trials on new anticoagulants and better use of established anticoagulants. He takes a special interest in clinical-medical education of healthcare professionals, patients and the public. His three main professional goals for the next 5 years are to (1) enhance national and local patient and health care provider education activities on venous thromboembolism, (2) continue to build the UNC “Athletes and Blood Clot Program”, (3) support trainees in their career development in the field of coagulation/non-malignant hematology.

DOM Grand Rounds- Dr. Janet Rubin presents: "Why Exercise Works."
2025-04-10 12:00 - 13:00 | Room 4008 Old Clinic Auditorium, Chapel Hill, NC, United States
Janet Rubin MD, is a Sarah Graham Kenan Professor of Medicine, Vice Chair for Research in the Department of Medicine at the University of North Carolina @ Chapel Hill and an endocrinologist who specializes in treating patients with metabolic disorders of bone.
Dr. Rubin’s research aims to understand molecular mechanisms by which physical forces regulate the behavior of cells involved in bone remodeling. This research has led her lab into studies of mesenchymal cell cytoskeleton and nuclear structure, which serve as paradigms for effects of the mechanical environment on all cells. The lab has contributed to more than 160 published articles and has been continuously federally funded since 1985.
Dr. Rubin further works within the Department of Medicine to ensure the success of junior physician-scientists and to improve and empower the scientific presence of research faculty in our 400+ faculty academic operation. Her work helping junior scientists to write excellent grants is one of her points of greatest pride.

Email: jrubin@med.unc.edu
Research information: https://www.researchgate.net/profile/Janet-Rubin

DOM Medicine Grand Rounds- Dr. Ross J. Simpson Jr. presents: Awareness, Treatment, and Control of Sudden Death
2025-03-27 12:00 - 13:00 | Room 4008 Old Clinic Auditorium, Chapel Hill, NC, United States
Dr. Simpson is Professor of Medicine and Clinical Professor of Epidemiology at the University of North Carolina, Chapel Hill. He received his MD from Georgetown University and completed further training in internal medicine and cardiology at the University of Illinois Hospital, Chicago. He received a PhD in Epidemiology from UNC. He formerly served as Medical Director and Principal Clinical Coordinator at the Carolinas Center for Medical Excellence. His research interests include the epidemiology and prevention of sudden unexpected death in adults, as well as the management of hypercholesterolemia, hypertension, and cardiovascular disease.

DOM Medicine Grand Rounds- Dr. Christos Mantzoros presents: "MASH: The New Kid on the Cardiometabolic Block: From Better Understanding of Physiology to Novel Diagnostic and Therapeutic Solutions for a Still Unmet Clinical Need."
2025-03-20 12:00 - 13:00 | Room 4008 Old Clinic Auditorium, Chapel Hill, NC, United States
Current Positions
Christos S. Mantzoros, MD, DSc, PhD h.c. mult. is a Professor of Medicine at Harvard Medical School. He has also served as a Professor of Environmental Health at the Harvard School of Public Health and adj. Professor of Medicine at the Boston University School of Medicine. He is also Chief of Endocrinology, Diabetes, and Metabolism at Boston VA Healthcare System and serves as Director of Human Nutrition, a division he created while at Beth Israel Deaconess Medical Center at Harvard Medical School. He is Board Certified and Licensed to practice in both EU and USA and he actively practices in both the inpatient and outpatient settings. He has served as a Board Member of HCHC and is currently on the Board of Alba Graduate Business School.

Education and Training
Dr. Mantzoros earned his medical degree from Athens University Medical School in Athens, Greece, where he also completed his DSc in clinical epidemiology in conjunction with the Harvard School of Public Health. Dr. Mantzoros completed his residency at Wayne State University in Detroit, MI. He then completed a fellowship in endocrinology, diabetes, and metabolism, as well as clinical nutrition in Longwood Medical Area Program at Harvard Medical School in Boston, MA. He also earned a Master’s degree in Public Health from Harvard School of Public Health and a Master’s degree in Clinical Investigation from Harvard Medical School and MIT.

Clinical Trials and Research Expertise
Dr. Mantzoros views obesity and its comorbidities as the next frontier in translational medicine. His work has provided critical insights into the physiology of energy homeostasis, the pathophysiological mechanisms and therapeutics of obesity and cardio-kidney-metabolic disease. Firstly, his pioneering studies on leptin and adiponectin defined the roles thereof in neuroendocrine regulation, energy homeostasis, and obesity, including the delineation of leptin resistance in obesity. Secondly, his lab has unveiled mechanisms governing the regulation of gastrointestinal hormones and incretins, e.g. GLP-1, and GIP, along with the effects of myokines such as activins and follistatins, elucidating their impact on the brain and body composition and offering therapeutic insights into the use of incretin analogs and myokine-based interventions for treating obesity and diabetes. Lastly, his research on MASLD/MASH, cardiovascular disease, and malignancies integrates omics technologies and AI-driven diagnostics to develop non-invasive tools and targeted therapies, providing a comprehensive approach to improving metabolic and overall health. Dr. Mantzoros’ research includes in-depth neuroscientific and metabolic studies spanning the entire spectrum from drug discovery, to preclinical, to observational and genetic epidemiology studies, to PK/PD and phase I-IV clinical trials (mostly investigator initiated and run but also multicenter RCTs, more than 135 in total), to real world studies. A trusted advisor to industry and foundations, he is also a stellar educator who has created and leads novel clinical training and education programs. Among the 185 persons who graduated from his own Laboratory, 2 are CEOs, 2 CMOs and many are VPs or scientists in pharma, 16 are full Prof. and many Associate and Assist. Prof. in academia.

Publications, Leadership, and Associations
Dr. Mantzoros is an elected member of American Society for Clinical Investigation and a Fellow of American College of Physicians and the American Association of Clinical Endocrinology. He has received many honors and awards, including four honorary PHDs, many honorary Professorships worldwide, the TOPS Award from The Obesity Society, the Outstanding Clinical Investigator Award from the Endocrine Society, and the Gerald Reaven Distinguished Leader in Insulin Resistance Award from the World Congress on Insulin Resistance, Diabetes & Cardiovascular Disease. He will be receiving the 2025 Outstanding Scholarly Physician award by the Endocrine Society. Dr. Mantzoros has published two books, Diabetes and Obesity and Nutrition and Metabolism. He also serves on the editorial boards of several scientific journals and he is Editor in Chief of Metabolism, Clinical & Experimental, the rankings of which he elevated from bottom 20% when he took over to top 3% currently. He has been an invited speaker at numerous national and international scientific meetings. Moreover, Dr. Mantzoros has published more than 1,100 scientific papers on topics including obesity, Cardio Kidney Metabolic Health, GLP-1 RAs and centrally acting agonists, adipokines, myokines and skeletal muscle changes in healthy and overweight individuals, obesity and weight loss management, obesity and neurocognitive abnormalities and malignancies. He has also coauthored more than 220 collaborative papers with the Look Ahead Group. His corpus received more than 176,000 citations with an H-index of 162 (Google Scholar). He has applied for more than 20 patents and has received most, while others are pending.

DOM Medicine Grand Rounds- Dr. Michael Cunningham: "Don't Blink: Catching GCA Before it Blinds."
2025-03-13 12:00 - 13:00 | Room 4008 Old Clinic Auditorium, Chapel Hill, NC, United States

DOM Medicine Grand Rounds- Dr. Rumey Ishizawar presents: "UNC Immuno-Oncology Group (IOG) Collaborative Efforts to Address Immune Related Adverse Events (irAEs)"
2025-02-27 12:00 - 13:00 | Room 4008 Old Clinic Auditorium, Chapel Hill, NC, United States
Dr. Rumey Ishizawar is an Associate Professor of Medicine and Program Director for the Adult Rheumatology Fellowship at UNC. She completed her MSTP training at the University of Virginia where her doctoral research was focused on Breast Cancer Cell Signaling through EGF Receptor Family members before pursuing Internal Medicine Residency and a Rheumatology Fellowship at Brigham Women’s Hospital. Her post-doctoral research included examining post translational regulation of cytokines and rheumatoid arthritis risk gene alleles in CD4+ T cell biology. She joined UNC School of Medicine faculty in July 2015 and initiated the UNC Immuno-Oncology Group (IOG) in 2017 which is focused on addressing immune-related adverse events triggered by immune checkpoint inhibitors in cancer patients through a collaborative model for both clinical care and research. Beyond her work with the UNC IOG, Dr. Ishizawar is involved in quality initiatives in medical education and management of patients with rheumatoid arthritis.

Medicine Grand Rounds- Dr. David Weber presents: "Vaccine Update"
2025-02-06 12:00 - 13:00 | Room 4008 Old Clinic Auditorium, Chapel Hill, NC, United States
Dr. David Jay Weber is currently the Charles Addison and Elizabeth Ann Sanders Distinguished Professor of Medicine, Pediatrics and Epidemiology, University of North Carolina (UNC), Chapel Hill, NC, USA. Dr. Weber received his Medical Degree from the University of California, San Diego in 1977, a Master’s in Public Health from Harvard University in 1985, and completed his medicine residency and infectious disease fellowship at the Massachusetts General Hospital in 1985. He is Board Certified in Internal Medicine, Infectious Disease, Critical Care Medicine, and Preventive Medicine. Dr. Weber serves as an Associate Chief Medical Office, Associate Chief Quality Officer and Medical Director of Infection Prevention for the UNC Medical Center. He is the President of the Society for Healthcare Epidemiology of America and the Associate Editor of Infection Control & Hospital Epidemiology. He is an Associate Editor of the journal Vaccine. Dr. Weber has published more than 575 scientific papers in the peer-reviewed literature cited in PubMed and more than 700 total papers and chapters. He is a member of the CDC Hospital Infection Control Practices Advisory Committee (HICPAC) and on the following working group: National Health Surveillance Network (Chair), Dental Water Lines (Chair), and Occupational Health for Healthcare personnel. Dr. Weber is an Expert Advisor for Clean Hospitals, Geneva. He Chairs, the NC Dept. of Health, TB Advisory Committee. His research interests include the epidemiology of healthcare-associated infections, disinfection and sterilization, new and emerging infectious diseases (highly communicable pathogens including SARS-CoV-2, HPAI, newly emerging pathogens including Candida auris), response to biothreats, nontuberculous mycobacteria, control of drug-resistant pathogens, immunization practices, zoonotic diseases, and epidemiology of tuberculosis.

Medicine Grand Rounds- Dr. Gwenn A. Garden presents: "Update on Alzheimer's Disease Diagnosis and Treatment"
2025-01-30 12:00 - 13:00 | Room 4008 Old Clinic Auditorium, Chapel Hill, NC, United States
Dr. Garden’s Alzheimer’s disease (AD) research includes studies of the regulation of the inflammatory response in AD, as well as pathogenic molecular cascades contributing to neuronal degeneration in AD. She aims to collaborate with other researchers in order to translate her laboratory findings into the setting of research using human tissues, human stem cells, human serum and CSF samples, and potentially human patients.
Dr. Garden’s Alzheimer’s disease (AD) research includes studies of the regulation of the inflammatory response in AD, as well as pathogenic molecular cascades contributing to neuronal degeneration in AD. She aims to collaborate with other researchers in order to translate her laboratory findings into the setting of research using human tissues, human stem cells, human serum and CSF samples, and potentially human patients.

Medicine Grand Rounds-Dr. Ana Felix presents: " Neurology in 2025: Evidence-Based Insights Transforming Patient Care."
2025-01-23 12:00 - 13:00 | Room 4008 Old Clinic Auditorium, Chapel Hill, NC, United States
Dr Felix is a Clinician Educator, embedded Neurologist with UNC Internal Medicine and UNC Geriatrics at Eastowne with fellowship training in Vascular Neurology and offering General Neurology evaluations. Dr. Felix is also the Neurologist for the UNC Brain and Body Program, funded by the NFLPA Trust.

Medicine Grand Rounds- Dr. Jeanne Marrazzo presents: "Opportunities and Challenges in the Infectious Disease Field: A Perspective from NIAID"
2025-01-16 12:00 - 13:00 | Room 4008 Old Clinic Auditorium, Chapel Hill, NC, United States
Dr. Marrazzo is the Director of the National Institute of Allergy and Infectious Diseases (NIAID) at the U.S. National Institutes of Health, where she oversees a $6.3 billion budget that supports research to advance the understanding, diagnosis, and treatment of infectious, immunologic, and allergic diseases. Prior to taking that position in 2023, she was the C. Glenn Cobbs Endowed Chair and Director of the Division of Infectious Diseases at the University of Alabama at Birmingham Heersink School of Medicine (UAB). She is a Fellow of the American College of Physicians and of the Infectious Diseases Society of America (IDSA), and was Treasurer of the IDSA from 2021-2023, having served on the board since 2018. She was Chair of the American Board of Internal Medicine Council from 2015-2018.
Dr. Marrazzo has a broad research portfolio that includes the relationships between the vaginal microbiome and female reproductive tract infections, HIV pre-exposure prophylaxis, hormonal contraception, and risk of STI/HIV acquisition. She led UAB’s participation in the RECOVER trial, funded by NIH to study post-acute sequelae of SARS-CoV-2 infection, and a large clinical trial of the meningococcal Group B vaccine rMenB+OMV NZ (Bexsero) to prevent gonococcal infection. She chaired the Biomedical Science Committee of the HIV Prevention Trial Network, the group tasked with integrating the biomedical science agenda across numerous clinical trials of antiretroviral prevention agents. She was also a Co-PI of the NIH-funded Infectious Disease Clinical Research Consortium that leads the Vaccine Treatment and Evaluation Units as well as NIH-funded STI clinical trials. She has been a leading voice in educating colleagues, the community, and the media during the COVID-19 pandemic.

Medicine Grand Rounds- Dr. Jonathan Parr presents: Emergence of Diagnostic- and Drug-Resistant Malaria
2025-01-09 12:00 - 13:00 | Room 4008 Old Clinic Auditorium, Chapel Hill, NC, United States
Dr. Parr studies the molecular epidemiology of infectious diseases. He is broadly interested in applying cutting-edge molecular and genomic tools to solve problems faced by marginalized populations across the globe. His work has focused on malaria in the Democratic Republic of the Congo and other sites, but he has recently expanded his portfolio to include translational studies of viral hepatitis and syphilis. Dr. Parr is a founding member of the Infectious Disease Epidemiology and Ecology Lab at UNC (IDEEL, www.ideelresearch.org). He has collaborated with the World Health Organization on efforts to improve malaria diagnosis and treatment and is as an Associate Editor for Healthcare: The Journal of Delivery Science and Innovation. During the pandemic, he has served as co-director of UNC infectious diseases’ inpatient COVID-19 services. Dr. Parr and his work have been featured in the New York Times, Washington Post, CNN, and other media outlets.

DOM Medicine Grand Rounds- Dr. Klara Klein presents: "Rethinking Type 2 Diabetes: From Research to Practice."
2024-12-19 12:00 - 13:00 | Room 4008 Old Clinic Auditorium, Chapel Hill, NC, United States
I am a MD/PhD trained investigator with an interest in conducting stakeholder-engaged clinical trials to advance the care of people living with diabetes and chronic kidney disease. My research path has spanned experiences in small molecule synthesis and drug development, molecular biology, animal models of disease, and most recently clinical trials. My early focus was on basic research, but I sought collaborative mentors who were interested in basic mechanisms involved in drug discovery that would ultimately impact human health. My early work resulted in six publications (three first author publications, including a cover article for Developmental Cell) and was funded by a Ruth L. Kirschstein Individual Predoctoral National Research Service Award (NIH NHLBI F30 HL118932, PI: Klein, Mentor: Caron). More importantly, my basic science training brought unique understanding of the drug development process and influenced my career goal to work in clinical trials, where I can bring bench research to the bedside.
As an endocrinology fellow, I transitioned from basic science to diabetes clinical trials. During this transition, I have continued to publish successfully. I have been fortunate to work with pharmaceutical companies on both large and small clinical trials, but I have been consistently disappointed in the lack of representation in clinical research and the time it takes for effective therapies to reach patients at need. As a diabetes clinical trialist, I have become passionate about closing the “research-to-practice-gap” through the conduct of stakeholder-engaged clinical trials. I have also become increasingly interested in leveraging the electronic medical record to expand clinical trial reach and to encourage early use of state-of-the-art therapeutics. While I have gained important experience as an investigator on industry sponsored clinical trials, I require foundational training in stakeholder engagement, implementation science, and informatics in order to independently design, execute, and implement stakeholder-engaged clinical trials that are broadly representative of the disease population.
As a tenure-track junior faculty member (starting in July 2022) with 75% protected time guaranteed and a start-up package, I aim to conduct new research with potential to (1) improve reach and representativeness of the clinical trials conducted in the Endocrine Diabetes and Obesity Clinical Research Unit (EnDO CRU) and (2) hasten to acceptance of effective therapeutics. To do so, I will focus on to elucidating the setting-specific barriers and feasibility of enrolling patients from North Carolina community-based practices and develop a tool to facilitate identification and enrollment of eligible patients across North Carolina. This work has potential to enhance enrollment efficiency, increase trial participant representativeness, and deepen community practitioner buy-in, all essential factors in promoting post-trial adoption of effective therapies.
I have assembled a mentorship team that consists of leaders in stakeholder engagement and implementation science, clinical informatics, and diabetes and kidney disease clinical trials. Dr. Jenny Flythe (stakeholder engagement and implementation science) will serve as my primary mentor. Drs. Emily Pfaff (clinical informatics) and Buse (clinical trials, diabetes) will serve as co-mentors. Under their guidance, I will pursue coursework in implementation science that will ultimately help me to engage key stakeholders to design and implement studies that best serve the patient population and the providers who care for them. I will also pursue training in basic informatics to facilitate effective collaboration with data scientists to develop tools aimed at increasing study population diversity and encourage early use of approved therapies. My mentorship team is enthusiastic about my proposed work and has the expertise required to ensure success. Each is deeply committed to training me to become an independent investigator. Completion of these aims and training objectives will cement the pathway toward becoming an independent human subjects researcher capable of developing novel therapeutics that are quickly and broadly distributed to improve both diabetes and advanced kidney disease care.

DOM Medicine Grand Rounds- Dr. Andrea Coviello presents: "Treating Obesity: 3 Things I Want You to Know."
2024-12-12 12:00 - 13:00 | Room 4008 Old Clinic Auditorium, Chapel Hill, NC, United States
As a board-certified endocrinologist and obesity medicine specialist, my research focus has been on the neuroendocrine control of reproduction and metabolism and the influence of reproductive hormones on metabolism and cardiovascular disease. This project aligns with my research goals as it focuses on the treatment of obesity and related endocrinology disorders in relation to newer prescribed incretins and I am excited to be part of this team in my role as a co-Investigator.
My research has encompassed clinical and genetic epidemiology studies in population-based cohorts such as the Framingham Heart Study (FHS) and NHANES as well as translational clinical research. I am working with the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Consortium as a FHS investigator on the genetic influences of reproductive traits such as menopause as well as circulating gonadal and adrenal sex hormones and their relationships to health and chronic disease. My clinical research has included clinical trials of testosterone therapy in men. In women, I have studied the metabolic disorders associated with androgen excess in women with polycystic ovary syndrome (PCOS) as well as the metabolic and cardiovascular sequelae of higher androgens in women of white European ancestry (1RO1HL094755-01A2). I mentor a junior investigator with a BIRCWH K12 (Duke) examining the role of sex steroids in hidradenitis in women with PCOS.
My clinical trial work has shifted to focus on industry sponsored trials in obesity, diabetes, lipid disorders and fatty liver disease. I have clinical expertise in the treatment of obesity and related endocrinology disorders combined with research expertise in reproductive endocrinology in the effects of sex steroids on health and disease. I am currently developing a clinical trial program in obesity and obesity related disorders in the Department of Medicine’s Clinical Research Unit. As the Director of the UNC Weight Management Program with clinical expertise in the treatment of obesity and related endocrinology disorders I am uniquely qualified to facilitate research, specifically clinical trials, with obesity and obesity related metabolic disorders.

DOM Medicine Grand Rounds-Dr. David Weber presents: "Hurricanes and Floods: Impact with a Focus on Infectious Diseases."
2024-11-21 12:00 - 13:00 | Room 4008 Old Clinic Auditorium, Chapel Hill, NC, United States
Dr. David Jay Weber is currently the Charles Addison and Elizabeth Ann Sanders Distinguished Professor of Medicine, Pediatrics and Epidemiology, University of North Carolina, Chapel Hill, NC, USA. Dr. Weber received his Medical Degree from the University of California, San Diego in 1977, a Master’s in Public Health from Harvard University in 1985, and completed his medicine residency and infectious disease fellowship at the Massachusetts General Hospital in 1985. He is Board Certified in Internal Medicine, Infectious Disease, Critical Care Medicine, and Preventive Medicine. Dr. Weber serves as an Associate Chief Medical Office, Associate Chief Quality Officer and Medical Director of Infection Prevention for the UNC Medical Center. He is the President Elect of the Society for Healthcare Epidemiology of America and the Deputy Editor of Infection Control & Hospital Epidemiology. He is an Associate Editor of the journal Vaccine. Dr. Weber has published more than 575 scientific papers in the peer-reviewed literature cited in PubMed and more than 700 total papers and chapters. He is a member of the CDC Hospital Infection Control Practices Advisory Committee (HICPAC) and on the following working group: National Health Surveillance Network (Chair), Dental Water Lines (Chair), and Occupational Health for Healthcare personnel. Dr. Weber is an Expert Advisor for Clean Hospitals, Geneva. He Chairs, the NC Dept. of Health, TB Advisory Committee. His research interests include the epidemiology of healthcare-associated infections, disinfection and sterilization, new and emerging infectious diseases (highly communicable pathogens including SARS-CoV-2, HPAI, newly emerging pathogens including Candida auris), response to biothreats, nontuberculous mycobacteria, control of drug resistant pathogens, immunization practices, zoonotic diseases, and epidemiology of tuberculosis.

DOM Grand Rounds- 2024 Alan Jacob's Memorial Lectures Dr. Donald Bordley presents: "Teacher- Learner- Patient: The Heart of Medical Education"
2024-11-14 12:00 - 13:00 | Room 4008 Old Clinic Auditorium, Chapel Hill, NC, United States
Dr. Bordley is a native of Cooperstown, New York. He majored in English at Yale University and received his MD degree from Johns Hopkins University. He carried out his residency training, including Chief Residency, and his General Medicine Fellowship at Strong Memorial Hospital of the University of Rochester. He was Director of the Internal Medicine Residency Program at Strong Memorial Hospital for 15 years from 1997 until 2012 and Vice Chair of Medicine for Education from 1997 until his retirement in 2018. He is now Professor Emeritus of Medicine. Dr. Bordley is very active nationally in Internal Medicine Resident Education and is a past president of the national Association of Program Directors in Internal Medicine. His outside interests include bicycling, hiking, skiing and playing classical and folk/blues guitar.

Medicine Grand Rounds- Dr. Paul Chelminski presents: "Patients as Partners in Physician Wellbeing"
2024-11-07 12:00 - 13:00 | Room 4008 Old Clinic Auditorium, Chapel Hill, NC, United States
Dr. Paul Chelminski is a native New Yorker whose gateway school to the south was Duke University. After graduating with a degree in Medieval and Renaissance Studies, he spent two years in French-speaking west Africa as a Peace Corps volunteer in Mali. He completed all of his medical training at UNC Chapel Hill. He is an addicted storyteller who believes that relationships with patients are an overlooked source of physician wellbeing.
