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DTSTART;TZID=America/New_York:20170919T140000
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SUMMARY:McAllister Heart Institute Seminar Series: Christopher Kontos\, MD\, New Insights into Skeletal Muscle-Endothelial Cell Interactions in Peripheral Artery Disease
DESCRIPTION:Speaker: Christopher Kontos\, MD. Associate Professor of Medicine\, Duke UniversityTopic: “New Insights into Skeletal Muscle-Endothelial Cell Interactions in Peripheral Artery Disease” \nPresentation Preview: Peripheral artery disease (PAD) is caused by atherosclerotic obstruction of the peripheral arteries\, most commonly the legs. The clinical manifestations of PAD include intermittent claudication\, characterized by pain with exertion that is relieved by rest\, and critical limb ischemia (CLI)\, in which patients experience rest pain with or without tissue necrosis and gangrene. Traditionally\, these different clinical presentations were thought to be due to differences in the severity of atherosclerotic vascular disease and subsequent differences in limb blood flow. However\, individuals with the same degree of vascular disease can present with vastly different phenotypes\, suggesting that genetics contribute to the different manifestations of PAD. Recent insights from our group have demonstrated that the response of skeletal muscle cells to ischemia\, independent of vascular growth or tissue perfusion\, plays an important role in determining outcomes after limb ischemia. In a mouse model of limb ischemia\, a polymorphism in BAG3 (Bcl2-associated athanogene-3) was found to play a key role in determining tissue survival vs. loss after limb ischemia\, and its potential mechanisms of action and role as a therapeutic target in PAD will be discussed. In addition\, several receptors expressed primarily on endothelial cells have been found play a role in modulating skeletal muscle cellular responses to injury\, and these receptors’ potential roles in the response to PAD and skeletal muscle differentiation will be discussed.
URL:https://www.med.unc.edu/medicine/event/mcallister-heart-institute-seminar-series-christopher-kontos-md-new-insights-into-skeletal-muscle-endothelial-cell-interactions-in-peripheral-artery-disease/
CATEGORIES:Medicine Grand Rounds
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DTSTART;TZID=America/New_York:20170921T120000
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UID:10000925-1505995200-1505998800@www.med.unc.edu
SUMMARY:Medicine Grand Rounds\, Kenneth Ataga\, "Pharmacological Therapies for Sickle Cell Disease: Beyond Hydroxyurea"
DESCRIPTION:Dr. Ataga is the director of the UNC Comprehensive Sickle Cell Program. His clinical research is focused on the vasculopathy of sickle cell disease\, with an emphasis on pulmonary hypertension and renal complications\, and coagulation activation in sickle cell disease. \nIn addition\, he has a strong research interest in the development of new therapies for sickle cell disease. His clinical trials in sickle cell disease are funded by the National Institutes of Health and the pharmaceutical industry. Results from an international\, multicenter phase 2 clinical trial led by Dr. Ataga were published online by the New England Journal of Medicine last year\, and were presented at the annual meeting of the American Society of Hematology in San Diego. The trial found that an investigational compound called SeIG1 dramatically reduces sickle cell pain crises. \nSickle cell disease is an inherited\, blood disorder that affects one out of every 500 African-Americans. There are approximately 80\,000 people in the United States with sickle cell disease. It is also one of the most common genetic diseases\, affecting millions of people worldwide. About half of the world’s sickle cell disease population lives in three countries: Nigeria\, India and the Democratic Republic of Congo. \nPatients with sickle cell disease suffer anemia and complications in which sickle-shaped red cells and white blood cells adhere to small vessels and block blood flow to downstream organs. This vaso-occlusive process results in intense pain and repeated hospitalizations. It also leads to progressive multi-organ dysfunction and premature death.
URL:https://www.med.unc.edu/medicine/event/sept-21/
CATEGORIES:Medicine Grand Rounds
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