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DTSTART;TZID=America/New_York:20171009T120000
DTEND;TZID=America/New_York:20171009T130000
DTSTAMP:20260417T050515
CREATED:20171009T160000Z
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SUMMARY:Cardiovascular Grand Rounds: Dr. Adam Caldwell\, “Genetics of Dilated Cardiomyopathy”
DESCRIPTION:Speaker: Adam Caldwell\, MD\, Chief Fellow\, UNC CardiologyTopic: Genetics of Dilated Cardiomyopathy
URL:https://www.med.unc.edu/medicine/event/cardiovascular-grand-rounds-dr-adam-caldwell-201cgenetics-of-dilated-cardiomyopathy201d/
CATEGORIES:Medicine Grand Rounds
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DTSTART;TZID=America/New_York:20171010T140000
DTEND;TZID=America/New_York:20171010T150000
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SUMMARY:MHI Seminar Series: Kari North\, PhD\, Genetic Diversity Turns a New PAGE in Our Understanding of Complex Traits
DESCRIPTION:Speaker: Kari North\, PhDTopic: Genetic Diversity Turns a New PAGE in Our Understanding of Complex Traits \nPresentation Preview: Genome-wide association studies (GWAS) have laid the foundation for many downstream investigations\, including the biology of complex traits\, drug development\, and clinical guidelines. However\, the dominance of European-ancestry populations in GWAS creates a biased view of human variation and hinders the translation of genetic associations into clinical and public health applications. To demonstrate the benefit of studying underrepresented populations\, the Population Architecture using Genomics and Epidemiology (PAGE) study conducted a GWAS of 26 clinical and behavioral phenotypes in 49\,839 non-European individuals. Using novel strategies for multi-ethnic analysis of admixed populations\, we confirm 574 GWAS catalog variants across these traits\, and find 28 novel loci and 42 residual signals in known loci. Our data show strong evidence of effect-size heterogeneity across ancestries for published GWAS associations\, which substantially restricts genetically-guided precision medicine. We advocate for new\, large genome-wide efforts in diverse populations to reduce health disparities.
URL:https://www.med.unc.edu/medicine/event/mhi-seminar-series-kari-north-phd-genetic-diversity-turns-a-new-page-in-our-understanding-of-complex-traits/
CATEGORIES:Medicine Grand Rounds
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DTSTART;TZID=America/New_York:20171012T120000
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SUMMARY:Medicine Grand Rounds\, Jonathan Juliano and Steve Meshnick\, "Evolving Concepts in Malaria Control and Treatment"
DESCRIPTION:In 2015\, there were 212 million malaria cases worldwide\, with the majority of deaths occurring in sub-Saharan Africa. In addition to the human burden of malaria\, the economic burden is vast. It is thought to cost African countries more than $12 billion every year in direct losses. For more than a decade\, Drs. Juliano and Meshnick have worked together to develop tools to control this epidemic. \nDr. Steve Meshnick is Professor and Associate Chair of the Department of Epidemiology. He has worked on tropical infectious diseases\, especially malaria\, for over 30 years and has published more than 340 scientific papers. He has a long-standing commitment to training and capacity-building and has been the primary mentor for 40 doctoral students and for ten post-docs\, including many from developing countries. \nOne of his former trainees\, Dr. Juliano\, and he are now co-leader of the Infectious Disease Epidemiology and Ecology Lab (IDEEL@UNC).  In addition to malaria\, the group has studied African Sleeping Sickness\, tick-borne diseases\, hepatitis\, and Pneumocystis carinii. The goal is to integrate laboratory and field research to develop better tools for infectious disease prevention and control. \nJonathan Juliano\, MD\, is an Associate Professor in the Department of Medicine’s Division of Infectious Diseases. He is the Medical Director of the UNC Hospital Antimicrobial Stewardship Program. He is also adjunct faculty in the Department of Epidemiology at the Gillings School of Global Public Health and a preceptor in UNC’s Curriculum in Genetics and Molecular Biology. Dr. Juliano also acts as the Associate Program Director of research and professional development for the UNC Infectious Disease Fellowship program.
URL:https://www.med.unc.edu/medicine/event/oct-12/
CATEGORIES:Medicine Grand Rounds
ATTACH;FMTTYPE=image/jpeg:https://www.med.unc.edu/medicine/wp-content/uploads/sites/945/2018/12/steve-meshnick.jpeg
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